1Q1M
| A Highly Efficient Approach to a Selective and Cell Active PTP1B inhibitors | 分子名称: | 5-{2-FLUORO-5-[3-(3-HYDROXY-2-METHOXYCARBONYL-PHENOXY)-PROPENYL]-PHENYL}-ISOXAZOLE-3-CARBOXYLIC ACID, Protein-tyrosine phosphatase, non-receptor type 1 | 著者 | Liu, G, Xin, Z, Pei, Z, Hajduk, P.J, Abad-Zapatero, C, Hutchins, C.W, Zhao, H, Lubben, T.H, Ballaron, S.J, Haasch, D.L, Kaszubska, W, Rondinone, C.M, Trevillyan, J.M, Jirousek, M.R. | 登録日 | 2003-07-22 | 公開日 | 2003-09-16 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor. J.Med.Chem., 46, 2003
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8HCM
| zebrafish IRF-11 DBD complex with DNA | 分子名称: | DNA (5'-D(P*GP*CP*TP*TP*TP*CP*AP*CP*TP*TP*TP*CP*TP*A)-3'), DNA (5'-D(P*TP*AP*GP*AP*AP*AP*GP*TP*GP*AP*AP*AP*GP*C)-3'), Interferon regulatory factor | 著者 | Wang, Z.X, Zhang, Y.A, Ouyang, S.Y. | 登録日 | 2022-11-02 | 公開日 | 2024-05-15 | 最終更新日 | 2024-09-04 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Crystal Structures of DNA-bound Fish IRF10 and IRF11 Reveal the Determinants of IFN Regulation. J Immunol., 213, 2024
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8HCL
| zebrafish IRF-10 DBD complex with DNA | 分子名称: | DNA (5'-D(P*AP*CP*TP*TP*TP*CP*AP*CP*TP*TP*CP*A)-3'), DNA (5'-D(P*TP*GP*AP*AP*GP*TP*GP*AP*AP*AP*GP*T)-3'), Interferon regulatory factor 10 | 著者 | Wang, Z.X, Zhang, Y.A, Ouyang, S.Y. | 登録日 | 2022-11-01 | 公開日 | 2024-05-15 | 最終更新日 | 2024-09-04 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Crystal Structures of DNA-bound Fish IRF10 and IRF11 Reveal the Determinants of IFN Regulation. J Immunol., 213, 2024
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8HCS
| zebrafish IRF-11 DBD | 分子名称: | Interferon regulatory factor | 著者 | Wang, Z.X, Zhang, Y.A, Ouyang, S.Y. | 登録日 | 2022-11-03 | 公開日 | 2024-05-15 | 最終更新日 | 2024-09-04 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Crystal Structures of DNA-bound Fish IRF10 and IRF11 Reveal the Determinants of IFN Regulation. J Immunol., 213, 2024
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7VON
| Native alpha-2-macroglobulin monomer | 分子名称: | Alpha-2-macroglobulin | 著者 | Huang, X, Wang, Y. | 登録日 | 2021-10-14 | 公開日 | 2022-11-16 | 最終更新日 | 2022-12-07 | 実験手法 | ELECTRON MICROSCOPY (5.2 Å) | 主引用文献 | Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor. Sci China Life Sci, 65, 2022
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8GZ4
| Crystal structure of MPXV phosphatase | 分子名称: | Dual specificity protein phosphatase H1, PHOSPHATE ION | 著者 | Yang, H.T, Wang, W, Huang, H.J, Ji, X.Y. | 登録日 | 2022-09-25 | 公開日 | 2023-05-17 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.802 Å) | 主引用文献 | Crystal structure of monkeypox H1 phosphatase, an antiviral drug target. Protein Cell, 14, 2023
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8HNW
| Crystal structure of HpaCas9-sgRNA surveillance complex bound to double-stranded DNA | 分子名称: | CRISPR-associated endonuclease Cas9, Non-target strand, Target strand, ... | 著者 | Sun, W, Cheng, Z, Wang, Y. | 登録日 | 2022-12-08 | 公開日 | 2023-07-19 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (3.41 Å) | 主引用文献 | AcrIIC4 inhibits type II-C Cas9 by preventing R-loop formation. Proc.Natl.Acad.Sci.USA, 120, 2023
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8HNT
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8HNS
| Crystal structure of an anti-CRISPR protein AcrIIC4 in apo form | 分子名称: | GLYCEROL, anti-CRISPR protein AcrIIC4 | 著者 | Sun, W, Cheng, Z, Yang, J, Wang, Y. | 登録日 | 2022-12-08 | 公開日 | 2023-07-19 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | 主引用文献 | AcrIIC4 inhibits type II-C Cas9 by preventing R-loop formation. Proc.Natl.Acad.Sci.USA, 120, 2023
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8HU4
| Limosilactobacillus reuteri N1 GtfB | 分子名称: | CITRIC ACID, DI(HYDROXYETHYL)ETHER, SODIUM ION, ... | 著者 | Dong, J.J, Bai, Y.X. | 登録日 | 2022-12-22 | 公開日 | 2023-12-27 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | 主引用文献 | Insights into the Structure-Function Relationship of GH70 GtfB alpha-Glucanotransferases from the Crystal Structure and Molecular Dynamic Simulation of a Newly Characterized Limosilactobacillus reuteri N1 GtfB Enzyme. J.Agric.Food Chem., 72, 2024
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8HWK
| Limosilactobacillus reuteri N1 GtfB-maltohexaose | 分子名称: | CITRIC ACID, DI(HYDROXYETHYL)ETHER, SODIUM ION, ... | 著者 | Dong, J.J, Bai, Y.X. | 登録日 | 2022-12-30 | 公開日 | 2024-01-03 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Insights into the Structure-Function Relationship of GH70 GtfB alpha-Glucanotransferases from the Crystal Structure and Molecular Dynamic Simulation of a Newly Characterized Limosilactobacillus reuteri N1 GtfB Enzyme. J.Agric.Food Chem., 72, 2024
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8HW3
| Limosilactobacillus reuteri N1 GtfB-acarbose | 分子名称: | 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose, GLYCEROL, SODIUM ION, ... | 著者 | Dong, J.J, Bai, Y.X. | 登録日 | 2022-12-28 | 公開日 | 2024-01-03 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.66 Å) | 主引用文献 | Insights into the Structure-Function Relationship of GH70 GtfB alpha-Glucanotransferases from the Crystal Structure and Molecular Dynamic Simulation of a Newly Characterized Limosilactobacillus reuteri N1 GtfB Enzyme. J.Agric.Food Chem., 72, 2024
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7VOO
| Induced alpha-2-macroglobulin monomer | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... | 著者 | Huang, X, Wang, Y, Ping, Z. | 登録日 | 2021-10-14 | 公開日 | 2022-10-19 | 最終更新日 | 2022-12-07 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor. Sci China Life Sci, 65, 2022
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7VBO
| Alginate binding domain CBM | 分子名称: | Alginate lyase, CALCIUM ION, SULFATE ION | 著者 | Ji, S.Q, She, Q. | 登録日 | 2021-09-01 | 公開日 | 2022-09-07 | 最終更新日 | 2023-04-12 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Identification and structural analysis of a carbohydrate-binding module specific to alginate, a representative of a new family, CBM96. J.Biol.Chem., 299, 2023
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7W07
| Itaconate inducible LysR-Type Transcriptional regulator (ITCR) in complex with itaconate, Space group C121. | 分子名称: | 2-methylidenebutanedioic acid, SULFATE ION, Transcriptional regulator, ... | 著者 | Sun, P.K, Wang, B, Li, X.J. | 登録日 | 2021-11-17 | 公開日 | 2022-10-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | A genetically encoded fluorescent biosensor for detecting itaconate with subcellular resolution in living macrophages. Nat Commun, 13, 2022
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7W08
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7W06
| Itaconate inducible LysR-Type Transcriptional regulator (ITCR) in complex with itaconate (SeMet labeled), Space group C121. | 分子名称: | 2-methylidenebutanedioic acid, CHLORIDE ION, SULFATE ION, ... | 著者 | Sun, P.K, Wang, B, Wang, Z.X, Qi, S, Li, X.J. | 登録日 | 2021-11-17 | 公開日 | 2022-10-26 | 最終更新日 | 2022-11-16 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | A genetically encoded fluorescent biosensor for detecting itaconate with subcellular resolution in living macrophages. Nat Commun, 13, 2022
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7W3Y
| CryoEM structure of human Kv4.3 | 分子名称: | Isoform 2 of Potassium voltage-gated channel subfamily D member 3 | 著者 | Ma, D.M, Guo, J.T. | 登録日 | 2021-11-26 | 公開日 | 2022-11-02 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for the gating modulation of Kv4.3 by auxiliary subunits. Cell Res., 32, 2022
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7W6S
| CryoEM structure of human KChIP2-Kv4.3 complex | 分子名称: | Isoform 2 of Potassium voltage-gated channel subfamily D member 3, Kv channel-interacting protein 2 | 著者 | Ma, D.M, Guo, J.T. | 登録日 | 2021-12-02 | 公開日 | 2022-11-02 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural basis for the gating modulation of Kv4.3 by auxiliary subunits. Cell Res., 32, 2022
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7W6N
| CryoEM structure of human KChIP1-Kv4.3 complex | 分子名称: | Isoform 2 of Potassium voltage-gated channel subfamily D member 3, Kv channel-interacting protein 1 | 著者 | Ma, D.M, Guo, J.T. | 登録日 | 2021-12-02 | 公開日 | 2022-11-02 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural basis for the gating modulation of Kv4.3 by auxiliary subunits. Cell Res., 32, 2022
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7W6T
| CryoEM structure of human KChIP1-Kv4.3-DPP6 complex | 分子名称: | Dipeptidyl aminopeptidase-like protein 6, Isoform 2 of Potassium voltage-gated channel subfamily D member 3, Kv channel-interacting protein 1 | 著者 | Ma, D.M, Guo, J.T. | 登録日 | 2021-12-02 | 公開日 | 2022-11-02 | 実験手法 | ELECTRON MICROSCOPY (3.85 Å) | 主引用文献 | Structural basis for the gating modulation of Kv4.3 by auxiliary subunits. Cell Res., 32, 2022
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7YDW
| Crystal structure of the MPND-DNA complex | 分子名称: | DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), MPN domain-containing protein | 著者 | Yang, M, Chen, Z. | 登録日 | 2022-07-04 | 公開日 | 2023-02-15 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | Structures of MPND Reveal the Molecular Recognition of Nucleosomes. Int J Mol Sci, 24, 2023
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7YDT
| Crystal structure of mouse MPND | 分子名称: | MPN domain containing protein | 著者 | Yang, M, Chen, Z. | 登録日 | 2022-07-04 | 公開日 | 2023-02-15 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.055 Å) | 主引用文献 | Structures of MPND Reveal the Molecular Recognition of Nucleosomes. Int J Mol Sci, 24, 2023
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7W0D
| Dicer2-LoqsPD-dsRNA complex at mid-translocation state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Dicer-2, isoform A, ... | 著者 | Su, S, Wang, J, Wang, H.W, Ma, J. | 登録日 | 2021-11-18 | 公開日 | 2022-04-27 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (4.18 Å) | 主引用文献 | Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD. Nature, 607, 2022
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7W0B
| Dicer2-LoqsPD complex at apo status | 分子名称: | Dicer-2, isoform A, Loquacious, ... | 著者 | Su, S, Wang, J, Wang, H.W, Ma, J. | 登録日 | 2021-11-18 | 公開日 | 2022-04-27 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.33 Å) | 主引用文献 | Structural insights into dsRNA processing by Drosophila Dicer-2-Loqs-PD. Nature, 607, 2022
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