4D90
 
 | | Crystal Structure of Del-1 EGF domains | | 分子名称: | 2-acetamido-2-deoxy-beta-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Chen, Q, Schurpf, T, Springer, T, Wang, J. | | 登録日 | 2012-01-11 | | 公開日 | 2012-05-30 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.601 Å) | | 主引用文献 | The RGD finger of Del-1 is a unique structural feature critical for integrin binding.
Faseb J., 26, 2012
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8EKX
 | | Structure of MBP-Mcl-1 in complex with MIK665 | | 分子名称: | (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy]phenyl]propanoic acid, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | 著者 | Judge, R.A, Judd, A.S, Souers, A.J. | | 登録日 | 2022-09-22 | | 公開日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients.
Commun Med (Lond), 3, 2023
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4M38
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5DI0
 | | Crystal structure of Dln1 | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Jia, N, Jiang, Y.L, Cheng, W, Wang, H.W, Zhou, C.Z, Chen, Y. | | 登録日 | 2015-08-31 | | 公開日 | 2016-02-03 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural basis for receptor recognition and pore formation of a zebrafish aerolysin-like protein.
Embo Rep., 17, 2016
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6CDH
 | | Crystal structure of ferrous form of the Cl-Tyr157 human cysteine dioxygenase with both uncrosslinked and crosslinked cofactor | | 分子名称: | Cysteine dioxygenase type 1, FE (II) ION, GLYCEROL, ... | | 著者 | Liu, A, Li, J, Shin, I. | | 登録日 | 2018-02-08 | | 公開日 | 2018-07-04 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.821 Å) | | 主引用文献 | Cleavage of a carbon-fluorine bond by an engineered cysteine dioxygenase.
Nat. Chem. Biol., 14, 2018
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6NAE
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8DEG
 | | Crystal structure of DLK in complex with inhibitor DN0011197 | | 分子名称: | Mitogen-activated protein kinase kinase kinase 12, methyl (1S,4S)-5-{(4P)-4-[5-amino-6-(difluoromethoxy)pyrazin-2-yl]-6-[(1R,4R)-2-azabicyclo[2.1.1]hexan-2-yl]pyridin-2-yl}-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate | | 著者 | Srivastava, A, Lexa, K, de Vicente, J. | | 登録日 | 2022-06-20 | | 公開日 | 2022-12-14 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | | 主引用文献 | Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in In Vitro and In Vivo Models of Amyotrophic Lateral Sclerosis.
J.Med.Chem., 65, 2022
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3LFM
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8HGW
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8HGV
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7VLX
 | | Cryo-EM structures of Listeria monocytogenes man-PTS | | 分子名称: | Mannose/fructose/sorbose family PTS transporter subunit IIC, PTS mannose family transporter subunit IID, alpha-D-mannopyranose | | 著者 | Wang, J.W. | | 登録日 | 2021-10-05 | | 公開日 | 2021-12-01 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | | 主引用文献 | Structural Basis of Pore Formation in the Mannose Phosphotransferase System by Pediocin PA-1.
Appl.Environ.Microbiol., 88, 2022
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7VLY
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7VI9
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7VII
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7VIA
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7VIK
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7N7P
 | | Cryo-EM structure of human TMEM120A | | 分子名称: | COENZYME A, Ion channel TACAN | | 著者 | Xue, J, Han, Y, Jiang, Y. | | 登録日 | 2021-06-10 | | 公開日 | 2021-09-01 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | | 主引用文献 | TMEM120A is a coenzyme A-binding membrane protein with structural similarities to ELOVL fatty acid elongase.
Elife, 10, 2021
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5CEO
 | | DLK in complex with inhibitor 2-((6-(3,3-difluoropyrrolidin-1-yl)-4-(1-(oxetan-3-yl)piperidin-4-yl)pyridin-2-yl)amino)isonicotinonitrile | | 分子名称: | 2-[[6-[3,3-bis(fluoranyl)pyrrolidin-1-yl]-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile, Mitogen-activated protein kinase kinase kinase 12 | | 著者 | HARRIS, S.F, YIN, J. | | 登録日 | 2015-07-07 | | 公開日 | 2015-10-14 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12).
J.Med.Chem., 58, 2015
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7N85
 | | Inner ring spoke from the isolated yeast NPC | | 分子名称: | Nucleoporin ASM4, Nucleoporin NIC96, Nucleoporin NSP1, ... | | 著者 | Akey, C.W, Rout, M.P, Ouch, C, Echevarria, I, Fernandez-Martinez, J, Nudelman, I. | | 登録日 | 2021-06-13 | | 公開日 | 2022-01-26 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (7.6 Å) | | 主引用文献 | Comprehensive structure and functional adaptations of the yeast nuclear pore complex.
Cell, 185, 2022
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7N84
 | | Double nuclear outer ring from the isolated yeast NPC | | 分子名称: | Nucleoporin 145c, Nucleoporin NUP120, Nucleoporin NUP133, ... | | 著者 | Akey, C.W, Rout, M.P, Ouch, C, Echevarria, I, Fernandez-Martinez, J, Nudelman, I. | | 登録日 | 2021-06-13 | | 公開日 | 2022-01-26 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (11.6 Å) | | 主引用文献 | Comprehensive structure and functional adaptations of the yeast nuclear pore complex.
Cell, 185, 2022
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5CEN
 | | Crystal structure of DLK (kinase domain) | | 分子名称: | Mitogen-activated protein kinase kinase kinase 12 | | 著者 | HARRIS, S.F, YIN, J. | | 登録日 | 2015-07-07 | | 公開日 | 2015-10-14 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12).
J.Med.Chem., 58, 2015
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7JTP
 | | Crystal structure of Protac MS67 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB | | 分子名称: | Elongin-B, Elongin-C, GLYCEROL, ... | | 著者 | Kottur, J, Jain, R, Aggarwal, A.K. | | 登録日 | 2020-08-18 | | 公開日 | 2021-10-06 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | | 主引用文献 | A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models.
Sci Transl Med, 13, 2021
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7JTO
 | | Crystal structure of Protac MS33 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB | | 分子名称: | 1,2-ETHANEDIOL, 3-methyl-N-(11-{[2-(4-{[4'-(4-methylpiperazin-1-yl)-3'-{[6-oxo-4-(trifluoromethyl)-5,6-dihydropyridine-3-carbonyl]amino}[1,1'-biphenyl]-3-yl]methyl}piperazin-1-yl)ethyl]amino}-11-oxoundecanoyl)-L-valyl-(4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide, Elongin-B, ... | | 著者 | Kottur, J, Jain, R, Aggarwal, A.K. | | 登録日 | 2020-08-18 | | 公開日 | 2021-10-06 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models.
Sci Transl Med, 13, 2021
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6VQF
 | | CRYSTAL STRUCTURE OF RAR-RELATED ORPHAN RECEPTOR C (NHIS-RORGT(244- 487)-L6-SRC1(678-692)) IN COMPLEX WITH AN INVERSE AGONIST | | 分子名称: | (1R,3S,4R)-4-[(3aR,9bR)-9b-[(4-fluorophenyl)sulfonyl]-7-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indole-3-carbonyl]-3-methylcyclohexane-1-carboxylic acid, GLYCEROL, Nuclear receptor ROR-gamma | | 著者 | Sack, J.S. | | 登録日 | 2020-02-05 | | 公開日 | 2020-04-08 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Discovery of BMS-986251: A Clinically Viable, Potent, and Selective ROR gamma t Inverse Agonist.
Acs Med.Chem.Lett., 11, 2020
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5CEP
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