3LFM

Crystal structure of the fat mass and obesity associated (FTO) protein reveals basis for its substrate specificity

Summary for 3LFM

• Entry DOI: 10.2210/pdb3lfm/pdb
• Descriptor: Protein fto, 3-methylthymidine, N-OXALYLGLYCINE, ... (4 entities in total)
• Functional Keywords: fat mass and obesity associated (fto) protein, fe2+/2-oxoglutarate (2-og)-dependent oxidative dna/rna demethylases, oxidoreductase
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus (By similarity): Q9C0B1
• Total number of polymer chains: 1
• Total formula weight: 57282.23

Authors

Chai, J.,Han, Z. (deposition date: 2010-01-18, release date: 2010-04-07, Last modification date: 2024-03-20)

• Primary citation: Han, Z.,Niu, T.,Chang, J.,Lei, X.,Zhao, M.,Wang, Q.,Cheng, W.,Wang, J.,Feng, Y.,Chai, J.; Crystal structure of the FTO protein reveals basis for its substrate specificity; Nature, 464:1205-1209, 2010; PubMed: 20376003; DOI: 10.1038/nature08921

Experimental method

X-RAY DIFFRACTION (2.5 Å)