3LFM

Crystal structure of the fat mass and obesity associated (FTO) protein reveals basis for its substrate specificity

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Protein fto	polymer	495	56823.0	1	UniProt (Q9C0B1) Pfam (PF12933) Pfam (PF12934)	Homo sapiens (human)	Fat mass and obesity-associated protein
2	B (A)	3-methylthymidine	non-polymer		256.3	1	Chemie (3DT)
3	C (A)	N-OXALYLGLYCINE	non-polymer		147.1	1	Chemie (OGA)
4	D (A)	FE (II) ION	non-polymer		55.8	1	Chemie (FE2)

Sequence modifications

A: 32 - 505 (UniProt: Q9C0B1)

PDB	External Database	Details
Met 11	-	expression tag
Gly 12	-	expression tag
Ser 13	-	expression tag
Ser 14	-	expression tag
His 15	-	expression tag
His 16	-	expression tag
His 17	-	expression tag
His 18	-	expression tag
His 19	-	expression tag
His 20	-	expression tag
Ser 21	-	expression tag
Ser 22	-	expression tag
Gly 23	-	expression tag
Leu 24	-	expression tag
Val 25	-	expression tag
Pro 26	-	expression tag
Arg 27	-	expression tag
Gly 28	-	expression tag
Ser 29	-	expression tag
His 30	-	expression tag
Met 31	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	56823.0
Non-Polymers*	Number of molecules	3
	Total formula weight	459.2
All*	Total formula weight	57282.2

*Water molecules are not included.