7WCT
 
 | | Crystal structure of FGFR4 kinase domain with 7v | | 分子名称: | Fibroblast growth factor receptor 4, GLYCEROL, SULFATE ION, ... | | 著者 | Chen, X.J, Lin, Q.M, Dai, S.Y, Chen, Y.H. | | 登録日 | 2021-12-20 | | 公開日 | 2022-03-30 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.106 Å) | | 主引用文献 | Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4.
J.Med.Chem., 65, 2022
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7WCW
 | | Crystal structure of FGFR4(V550L) kinase domain with 7v | | 分子名称: | Fibroblast growth factor receptor 4, SULFATE ION, ~{N}-[2-[[5-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1~{H}-indazol-3-yl]amino]-3-fluoranyl-5-(4-morpholin-4-ylpiperidin-1-yl)phenyl]propanamide | | 著者 | Chen, X.J, Lin, Q.M, Dai, S.Y, Chen, Y.H. | | 登録日 | 2021-12-20 | | 公開日 | 2022-03-30 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.317 Å) | | 主引用文献 | Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4.
J.Med.Chem., 65, 2022
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5ICA
 | | Structure of the CTD complex of UTP12, Utp13, Utp1 and Utp21 | | 分子名称: | Periodic tryptophan protein 2-like protein, Putative U3 snoRNP protein, Putative uncharacterized protein | | 著者 | Zhang, C, Ye, K. | | 登録日 | 2016-02-23 | | 公開日 | 2016-07-06 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (3.507 Å) | | 主引用文献 | Integrative structural analysis of the UTPB complex, an early assembly factor for eukaryotic small ribosomal subunits
Nucleic Acids Res., 44, 2016
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7DTZ
 | | FGFR4 complex with a covalent inhibitor | | 分子名称: | Fibroblast growth factor receptor 4, N-[2-[[5-[[2,6-bis(chloranyl)-3,5-dimethoxy-phenyl]methoxy]pyrimidin-2-yl]amino]-3-methyl-phenyl]-2-fluoranyl-prop-2-enamide, SULFATE ION | | 著者 | Chen, X.J, Dai, S.Y, Chen, Y.H. | | 登録日 | 2021-01-07 | | 公開日 | 2021-04-14 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Investigation of Covalent Warheads in the Design of 2-Aminopyrimidine-based FGFR4 Inhibitors.
Acs Med.Chem.Lett., 12, 2021
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5IC9
 | | Structure of the CTD complex of Utp12 and Utp13 | | 分子名称: | Putative uncharacterized protein | | 著者 | Zhang, C, Ye, K. | | 登録日 | 2016-02-23 | | 公開日 | 2016-07-06 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | | 主引用文献 | Integrative structural analysis of the UTPB complex, an early assembly factor for eukaryotic small ribosomal subunits
Nucleic Acids Res., 44, 2016
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5IC8
 | | Structure of UTP6 | | 分子名称: | Putative uncharacterized protein | | 著者 | Zhang, C, Ye, K. | | 登録日 | 2016-02-23 | | 公開日 | 2016-07-06 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Integrative structural analysis of the UTPB complex, an early assembly factor for eukaryotic small ribosomal subunits
Nucleic Acids Res., 44, 2016
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5IC7
 | | Structure of the WD domain of UTP18 | | 分子名称: | Putative uncharacterized protein, SULFATE ION | | 著者 | Zhang, C, Ye, K. | | 登録日 | 2016-02-22 | | 公開日 | 2016-07-06 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.331 Å) | | 主引用文献 | Integrative structural analysis of the UTPB complex, an early assembly factor for eukaryotic small ribosomal subunits
Nucleic Acids Res., 44, 2016
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7E3O
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5WFN
 | | Revised model of leiomodin 2-mediated actin regulation (alternate refinement of PDB 4RWT) | | 分子名称: | Actin-5C, Leiomodin-2, MAGNESIUM ION, ... | | 著者 | Yurtsever, Z, Eck, M.J, Dominguez, R. | | 登録日 | 2017-07-12 | | 公開日 | 2017-08-30 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Crystal structure of leiomodin 2 in complex with actin: a structural and functional reexamination
Biophys.J., 113, 2017
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5YKO
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5YKN
 | | crystal structure of Arabidopsis thaliana JMJ14 catalytic domain | | 分子名称: | NICKEL (II) ION, Probable lysine-specific demethylase JMJ14, ZINC ION | | 著者 | Yang, Z, Du, J. | | 登録日 | 2017-10-15 | | 公開日 | 2017-12-27 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure of the Arabidopsis JMJ14-H3K4me3 Complex Provides Insight into the Substrate Specificity of KDM5 Subfamily Histone Demethylases.
Plant Cell, 30, 2018
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1DST
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8Y20
 | | Crystal structure of the Mcl-1 in complex with A-1210477 | | 分子名称: | A-1210477, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | 著者 | Wang, H, Guo, M, Wei, H, Chen, Y. | | 登録日 | 2024-01-25 | | 公開日 | 2025-01-29 | | 最終更新日 | 2025-06-25 | | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | | 主引用文献 | Deciphering molecular specificity in MCL-1/BAK interaction and its implications for designing potent MCL-1 inhibitors.
Cell Death Differ., 32, 2025
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8Y1Y
 | | Crystal structure of the Mcl-1 in complex with a long BH3 peptide of BAK | | 分子名称: | BH3 peptide from Bcl-2 homologous antagonist/killer, Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION | | 著者 | Wang, H, Guo, M, Wei, H, Chen, Y. | | 登録日 | 2024-01-25 | | 公開日 | 2025-01-29 | | 最終更新日 | 2025-06-25 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Deciphering molecular specificity in MCL-1/BAK interaction and its implications for designing potent MCL-1 inhibitors.
Cell Death Differ., 32, 2025
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3HYF
 | | Crystal structure of HIV-1 RNase H p15 with engineered E. coli loop and active site inhibitor | | 分子名称: | 2-(3,4-dichlorobenzyl)-5,6-dihydroxypyrimidine-4-carboxylic acid, ACETATE ION, GLYCEROL, ... | | 著者 | Lansdon, E.B, Kirschberg, T.A. | | 登録日 | 2009-06-22 | | 公開日 | 2009-10-20 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information.
J.Med.Chem., 52, 2009
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8JUE
 | | Crystal structure of glutaminase C in complex with compound 11 | | 分子名称: | 2-(3-phenoxyphenyl)-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]ethanamide, Glutaminase kidney isoform, mitochondrial | | 著者 | Wang, X, Hanyu, S, Tingting, D. | | 登録日 | 2023-06-26 | | 公開日 | 2023-10-11 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | Targeting the Subpocket Enables the Discovery of Thiadiazole-Pyridazine Derivatives as Glutaminase C Inhibitors.
Acs Med.Chem.Lett., 14, 2023
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8Y1Z
 | | Crystal structure of the Mcl-1 in complex with a Short BH3 peptide of BAK | | 分子名称: | Induced myeloid leukemia cell differentiation protein Mcl-1, Short BH3 peptide from Bcl-2 homologous antagonist/killer | | 著者 | Wang, H, Guo, M, Wei, H, Chen, Y. | | 登録日 | 2024-01-25 | | 公開日 | 2025-01-29 | | 最終更新日 | 2025-06-25 | | 実験手法 | X-RAY DIFFRACTION (1.914 Å) | | 主引用文献 | Deciphering molecular specificity in MCL-1/BAK interaction and its implications for designing potent MCL-1 inhibitors.
Cell Death Differ., 32, 2025
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8JUB
 | | Crystal structure of glutaminase C in complex with compound 27 | | 分子名称: | 3-[2-oxidanylidene-2-[[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]amino]ethyl]benzoic acid, Glutaminase kidney isoform, mitochondrial | | 著者 | Wang, X, Hanyu, S, Tingting, D. | | 登録日 | 2023-06-26 | | 公開日 | 2023-10-11 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Targeting the Subpocket Enables the Discovery of Thiadiazole-Pyridazine Derivatives as Glutaminase C Inhibitors.
Acs Med.Chem.Lett., 14, 2023
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6N3H
 | | Crystal structure of Kelch domain of the human NS1 binding protein | | 分子名称: | Influenza virus NS1A-binding protein | | 著者 | Zhang, K, Shang, G, Padavannil, A, Fontoura, B.M.A, Chook, Y.M. | | 登録日 | 2018-11-15 | | 公開日 | 2018-12-12 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6N34
 | | Crystal structure of the BTB domain of Human NS1-BP | | 分子名称: | Influenza virus NS1A-binding protein | | 著者 | Zhang, K, Shang, G, Padavannil, A, Fontoura, B, Chook, Y.M. | | 登録日 | 2018-11-14 | | 公開日 | 2018-12-12 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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1FDP
 | | PROENZYME OF HUMAN COMPLEMENT FACTOR D, RECOMBINANT PROFACTOR D | | 分子名称: | PROENZYME OF COMPLEMENT FACTOR D | | 著者 | Jing, H, Macon, K.J, Moore, D, Delucas, L.J, Volanakis, J.E, Narayana, S.V.L. | | 登録日 | 1998-12-03 | | 公開日 | 1999-12-03 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural basis of profactor D activation: from a highly flexible zymogen to a novel self-inhibited serine protease, complement factor D.
Embo J., 18, 1999
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6KI2
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6KI1
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6K62
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6M1H
 | | CryoEM structure of human PAC1 receptor in complex with maxadilan | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | 著者 | Song, X, Wang, J, Zhang, D, Wang, H.W, Ma, Y. | | 登録日 | 2020-02-26 | | 公開日 | 2020-03-11 | | 最終更新日 | 2024-11-13 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism.
Cell Res., 30, 2020
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