7DTZ
FGFR4 complex with a covalent inhibitor
Summary for 7DTZ
Entry DOI | 10.2210/pdb7dtz/pdb |
Descriptor | Fibroblast growth factor receptor 4, N-[2-[[5-[[2,6-bis(chloranyl)-3,5-dimethoxy-phenyl]methoxy]pyrimidin-2-yl]amino]-3-methyl-phenyl]-2-fluoranyl-prop-2-enamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | inhibitor, covalent, crystal, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 35112.23 |
Authors | Chen, X.J.,Dai, S.Y.,Chen, Y.H. (deposition date: 2021-01-07, release date: 2021-04-14, Last modification date: 2023-11-29) |
Primary citation | Deng, W.,Chen, X.,Jiang, K.,Song, X.,Huang, M.,Tu, Z.C.,Zhang, Z.,Lin, X.,Ortega, R.,Patterson, A.V.,Smaill, J.B.,Ding, K.,Chen, S.,Chen, Y.,Lu, X. Investigation of Covalent Warheads in the Design of 2-Aminopyrimidine-based FGFR4 Inhibitors. Acs Med.Chem.Lett., 12:647-652, 2021 Cited by PubMed: 33859803DOI: 10.1021/acsmedchemlett.1c00052 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.01 Å) |
Structure validation
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