8QBD
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![BU of 8qbd by Molmil](/molmil-images/mine/8qbd) | Helical reconstruction of yeast eisosome protein Pil1 bound to membrane composed of lipid mixture +PIP2/+sterol (DOPC, DOPE, DOPS, cholesterol, PI(4,5)P2 35:20:20:15:10) | 分子名称: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine, Sphingolipid long chain base-responsive protein PIL1 | 著者 | Kefauver, J.M, Zou, L, Desfosses, A, Loewith, R.J. | 登録日 | 2023-08-24 | 公開日 | 2024-07-24 | 最終更新日 | 2024-08-28 | 実験手法 | ELECTRON MICROSCOPY (3.61 Å) | 主引用文献 | Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain. Nature, 632, 2024
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8QBG
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8QBE
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8QB9
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![BU of 8qb9 by Molmil](/molmil-images/mine/8qb9) | Helical reconstruction of yeast eisosome protein Pil1 bound to membrane composed of lipid mixture -PIP2/+sterol (DOPC, DOPE, DOPS, cholesterol 30:20:20:30) | 分子名称: | Sphingolipid long chain base-responsive protein PIL1 | 著者 | Kefauver, J.M, Zou, L, Desfosses, A, Loewith, R.J. | 登録日 | 2023-08-24 | 公開日 | 2024-07-24 | 最終更新日 | 2024-08-28 | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | 主引用文献 | Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain. Nature, 632, 2024
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5HBE
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![BU of 5hbe by Molmil](/molmil-images/mine/5hbe) | CDK8-CYCC IN COMPLEX WITH 8-[3-Chloro-5-(1-methyl-2,2-dioxo-2, 3-dihydro-1H-2l6-benzo[c]isothiazol-5-yl)-pyridin- 4-yl]-1-oxa-3,8-diaza-spiro[4.5]decan-2-one | 分子名称: | 1,2-ETHANEDIOL, 8-[3-chloranyl-5-[1-methyl-2,2-bis(oxidanylidene)-3~{H}-2,1-benzothiazol-5-yl]pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one, Cyclin-C, ... | 著者 | Musil, D, Blagg, J, Mallinger, A. | 登録日 | 2015-12-31 | 公開日 | 2016-02-03 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19. J.Med.Chem., 59, 2016
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5EBI
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![BU of 5ebi by Molmil](/molmil-images/mine/5ebi) | Crystal structure of a DNA-RNA chimera in complex with Ba2+ ions: a case of unusual multi-domain twinning | 分子名称: | BARIUM ION, DNA/RNA (5'-D(*C)-R(P*G)-D(P*C)-R(P*G)-D(P*C)-R(P*G)-3') | 著者 | Gilski, M, Drozdzal, P, Kierzek, R, Jaskolski, M. | 登録日 | 2015-10-19 | 公開日 | 2016-02-10 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.09 Å) | 主引用文献 | Atomic resolution structure of a chimeric DNA-RNA Z-type duplex in complex with Ba(2+) ions: a case of complicated multi-domain twinning. Acta Crystallogr D Struct Biol, 72, 2016
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6AK2
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![BU of 6ak2 by Molmil](/molmil-images/mine/6ak2) | Crystal structure of the syntenin PDZ1 domain in complex with the peptide inhibitor KSL-128018 | 分子名称: | Syntenin-1, peptide inhibitor KSL-128018 | 著者 | Jin, Z.Y, Park, J.H, Yun, J.H, Haugaard-Kedstrom, L.M, Lee, W.T. | 登録日 | 2018-08-29 | 公開日 | 2019-09-04 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.868 Å) | 主引用文献 | A High-Affinity Peptide Ligand Targeting Syntenin Inhibits Glioblastoma. J.Med.Chem., 64, 2021
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8TIC
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![BU of 8tic by Molmil](/molmil-images/mine/8tic) | Structure of human beta 1,3-N-acetylglucosaminyltransferase 2 with compound 1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(2-methylpropyl)-2-oxo-2,3-dihydro-1H-benzimidazole-5-carboxylic acid, CHLORIDE ION, ... | 著者 | Sudom, A, Min, X. | 登録日 | 2023-07-19 | 公開日 | 2023-12-06 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Imidazolone as an Amide Bioisostere in the Development of beta-1,3- N -Acetylglucosaminyltransferase 2 (B3GNT2) Inhibitors. J.Med.Chem., 66, 2023
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8SZ3
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![BU of 8sz3 by Molmil](/molmil-images/mine/8sz3) | Structure of human beta 1,3-N-acetylglucosaminyltransferase 2 with compound 7j | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-[(1S)-1-(5-bromopyridin-2-yl)ethyl]-3-[(2R)-3,3-dimethylbutan-2-yl]-2-oxo-2,3-dihydro-1H-benzimidazole-5-carboxamide, ... | 著者 | Sudom, A, Min, X. | 登録日 | 2023-05-26 | 公開日 | 2023-12-06 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | Imidazolone as an Amide Bioisostere in the Development of beta-1,3- N -Acetylglucosaminyltransferase 2 (B3GNT2) Inhibitors. J.Med.Chem., 66, 2023
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8TJC
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![BU of 8tjc by Molmil](/molmil-images/mine/8tjc) | Structure of human beta 1,3-N-acetylglucosaminyltransferase 2 with compound 8a | 分子名称: | (6M)-1-[(2R)-3,3-dimethylbutan-2-yl]-6-[(5S)-5-methyl-4-oxo-5-phenyl-4,5-dihydro-1H-imidazol-2-yl]-1,3-dihydro-2H-benzimidazol-2-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Sudom, A, Min, X. | 登録日 | 2023-07-20 | 公開日 | 2023-12-06 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Imidazolone as an Amide Bioisostere in the Development of beta-1,3- N -Acetylglucosaminyltransferase 2 (B3GNT2) Inhibitors. J.Med.Chem., 66, 2023
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6OV1
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![BU of 6ov1 by Molmil](/molmil-images/mine/6ov1) | Structure of Staphylococcus aureus RNase P protein mutant with defective mRNA degradation activity | 分子名称: | Ribonuclease P protein component | 著者 | Ha, L, Colquhoun, J, Noinaj, N, Das, C, Dunman, P, Flaherty, D.P. | 登録日 | 2019-05-06 | 公開日 | 2020-12-02 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Genetic and biochemical characterization of Staphylococcus aureus RnpA To Be Published
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8TBP
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![BU of 8tbp by Molmil](/molmil-images/mine/8tbp) | HLA-DRB1*15:01 in complex with smith antigen | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II histocompatibility antigen, DR alpha chain, ... | 著者 | Ting, Y.T, Broury, A, Ooi, J. | 登録日 | 2023-06-29 | 公開日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3.12621117 Å) | 主引用文献 | Smith-specific regulatory T cells halt the progression of lupus nephritis. Nat Commun, 15, 2024
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4LDB
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8TU2
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8TU0
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8TU1
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1DVQ
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![BU of 1dvq by Molmil](/molmil-images/mine/1dvq) | CRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN | 分子名称: | TRANSTHYRETIN | 著者 | Klabunde, T, Petrassi, H.M, Oza, V.B, Kelly, J.W, Sacchettini, J.C. | 登録日 | 2000-01-22 | 公開日 | 2001-01-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Rational design of potent human transthyretin amyloid disease inhibitors. Nat.Struct.Biol., 7, 2000
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1DVS
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![BU of 1dvs by Molmil](/molmil-images/mine/1dvs) | CRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN IN COMPLEX WITH RESVERATROL | 分子名称: | RESVERATROL, TRANSTHYRETIN | 著者 | Klabunde, T, Petrassi, H.M, Oza, V.B, Kelly, J.W, Sacchettini, J.C. | 登録日 | 2000-01-22 | 公開日 | 2001-01-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Rational design of potent human transthyretin amyloid disease inhibitors. Nat.Struct.Biol., 7, 2000
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4LD8
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4LV0
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4LV2
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7UMZ
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6VRV
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![BU of 6vrv by Molmil](/molmil-images/mine/6vrv) | Discovery of SARxxxx92, a pan-PIM kinase inhibitor, efficacious in a KG1 tumor model | 分子名称: | 4-chloro-1-{(1S)-1-[(3S)-3-fluoropyrrolidin-3-yl]ethyl}-3-methyl-1H-pyrrolo[2,3-b]pyridine-6-carboxamide, GLYCEROL, Serine/threonine-protein kinase pim-1 | 著者 | Barberis, C.E, Batchelor, J.D, Liu, J. | 登録日 | 2020-02-10 | 公開日 | 2020-11-04 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Discovery of SARxxxx92, a pan-PIM kinase inhibitor, efficacious in a KG1 tumor model. Bioorg.Med.Chem.Lett., 30, 2020
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1DVU
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![BU of 1dvu by Molmil](/molmil-images/mine/1dvu) | CRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN IN COMPLEX WITH DIBENZOFURAN-4,6-DICARBOXYLIC ACID | 分子名称: | DIBENZOFURAN-4,6-DICARBOXYLIC ACID, TRANSTHYRETIN | 著者 | Klabunde, T, Petrassi, H.M, Oza, V.B, Kelly, J.W, Sacchettini, J.C. | 登録日 | 2000-01-22 | 公開日 | 2001-01-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Rational design of potent human transthyretin amyloid disease inhibitors. Nat.Struct.Biol., 7, 2000
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1DVX
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![BU of 1dvx by Molmil](/molmil-images/mine/1dvx) | CRYSTAL STRUCTURE OF HUMAN TRANSTHYRETIN IN COMPLEX WITH DICLOFENAC | 分子名称: | 2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID, TRANSTHYRETIN | 著者 | Klabunde, T, Petrassi, H.M, Oza, V.B, Kelly, J.W, Sacchettini, J.C. | 登録日 | 2000-01-23 | 公開日 | 2001-01-23 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Rational design of potent human transthyretin amyloid disease inhibitors. Nat.Struct.Biol., 7, 2000
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