5L2Z
 
 | | Factor VIIa in complex with the inhibitor 1-[(2R,15R)-2-[(1-amino-4-fluoroisoquinolin-6-yl)amino]-4,15,17-trimethyl-3,12-dioxo-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaen-7-yl]cyclohexane-1-carboxylic acid | | 分子名称: | 1-[(2R,15R)-2-[(1-amino-4-fluoroisoquinolin-6-yl)amino]-4,15,17-trimethyl-3,12-dioxo-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaen-7-yl]cyclohexane-1-carboxylic acid, CALCIUM ION, Coagulation factor VII (Heavy Chain), ... | | 著者 | Wei, A. | | 登録日 | 2016-08-02 | | 公開日 | 2016-09-28 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Synthesis and P1' SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors.
Bioorg.Med.Chem.Lett., 26, 2016
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7CWO
 | | SARS-CoV-2 spike protein RBD and P17 fab complex | | 分子名称: | Spike glycoprotein, heavy chain of P17 Fab, light chain of P17 Fab | | 著者 | Wang, X, Wang, N. | | 登録日 | 2020-08-29 | | 公開日 | 2020-12-16 | | 最終更新日 | 2021-01-13 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection.
Cell Res., 31, 2021
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7CWL
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7CWM
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5U6J
 | | Factor VIIa in complex with the inhibitor 3-{[(2R)-17-ethyl-4-methyl-3,12-dioxo-7-[(propan-2-yl)sulfonyl]-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaen-2-yl]amino}benzamide | | 分子名称: | 3-{[(2R)-17-ethyl-4-methyl-3,12-dioxo-7-[(propan-2-yl)sulfonyl]-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaen-2-yl]amino}benzamide, CALCIUM ION, Coagulation factor VII Heavy Chain, ... | | 著者 | Wei, A. | | 登録日 | 2016-12-08 | | 公開日 | 2017-05-10 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Neutral macrocyclic factor VIIa inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
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4GL5
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5W3M
 | | CryoEM structure of rhinovirus B14 in complex with C5 Fab (33 degrees Celsius, molar ratio 1:1, full particle) | | 分子名称: | C5 antibody variable heavy domain, C5 antibody variable light domain, viral protein 1, ... | | 著者 | Liu, Y, Dong, Y, Rossmann, M.G. | | 登録日 | 2017-06-08 | | 公開日 | 2017-07-12 | | 最終更新日 | 2019-12-11 | | 実験手法 | ELECTRON MICROSCOPY (2.26 Å) | | 主引用文献 | Antibody-induced uncoating of human rhinovirus B14.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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4GL7
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5VEB
 | | Crystal structure of a Fab binding to extracellular domain 5 of Cadherin-6 | | 分子名称: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, Cadherin-6, anti-CDH6 Fab heavy chain, ... | | 著者 | Zhu, X, Bialucha, C.U, London, A, Clark, K, Hu, T. | | 登録日 | 2017-04-04 | | 公開日 | 2017-06-07 | | 最終更新日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | | 主引用文献 | Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers.
Cancer Discov, 7, 2017
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5W3O
 | | CryoEM structure of rhinovirus B14 in complex with C5 Fab (33 degrees Celsius, molar ratio 1:3, empty particle) | | 分子名称: | C5 antibody variable heavy domain, C5 antibody variable light domain, viral protein 1, ... | | 著者 | Liu, Y, Dong, Y, Rossmann, M.G. | | 登録日 | 2017-06-08 | | 公開日 | 2017-07-12 | | 最終更新日 | 2019-12-11 | | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | | 主引用文献 | Antibody-induced uncoating of human rhinovirus B14.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5W3L
 | | CryoEM structure of rhinovirus B14 in complex with C5 Fab (4 degrees Celsius, molar ratio 1:3, full particle) | | 分子名称: | C5 antibody variable heavy domain, C5 antibody variable light domain, viral protein 1, ... | | 著者 | Liu, Y, Dong, Y, Rossmann, M.G. | | 登録日 | 2017-06-08 | | 公開日 | 2017-07-12 | | 最終更新日 | 2019-12-11 | | 実験手法 | ELECTRON MICROSCOPY (2.71 Å) | | 主引用文献 | Antibody-induced uncoating of human rhinovirus B14.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5W3E
 | | CryoEM structure of rhinovirus B14 in complex with C5 Fab (33 degrees Celsius, molar ratio 1:3, full particle) | | 分子名称: | C5 antibody variable heavy domain, C5 antibody variable light domain, viral protein 1, ... | | 著者 | Liu, Y, Dong, Y, Rossmann, M.G. | | 登録日 | 2017-06-07 | | 公開日 | 2017-07-12 | | 最終更新日 | 2019-12-11 | | 実験手法 | ELECTRON MICROSCOPY (2.53 Å) | | 主引用文献 | Antibody-induced uncoating of human rhinovirus B14.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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3S7S
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3S79
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4I0P
 | | HLA-DO in complex with HLA-DM | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, GLYCEROL, ... | | 著者 | Guce, A.I, Mortimer, S.E, Stern, L.J. | | 登録日 | 2012-11-18 | | 公開日 | 2012-12-26 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism.
Nat.Struct.Mol.Biol., 20, 2013
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7TVA
 | | Stat5a Core in complex with AK2292 | | 分子名称: | DI(HYDROXYETHYL)ETHER, MALONATE ION, N-{5-[difluoro(phosphono)methyl]-1-benzothiophene-2-carbonyl}-3-methyl-L-valyl-L-prolyl-N-(5-{2-[(3R)-2,6-dioxopiperidin-3-yl]-1-oxo-2,3-dihydro-1H-isoindol-4-yl}pent-4-yn-1-yl)-N-methyl-N~3~-[4-(1,3-thiazol-2-yl)phenyl]-beta-alaninamide, ... | | 著者 | Meagher, J.L, Stuckey, J.A. | | 登録日 | 2022-02-04 | | 公開日 | 2023-02-15 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.835 Å) | | 主引用文献 | A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo.
Nat.Chem.Biol., 19, 2023
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7TVB
 | | Stat5A Core in Complex with AK305 | | 分子名称: | GLYCEROL, N-{5-[difluoro(phosphono)methyl]-1-benzothiophene-2-carbonyl}-3-methyl-L-valyl-L-prolyl-N,N-dimethyl-N~3~-[4-(1,3-thiazol-2-yl)phenyl]-beta-alaninamide, Signal transducer and activator of transcription 5A | | 著者 | Meagher, J.L, Stuckey, J.A. | | 登録日 | 2022-02-04 | | 公開日 | 2023-02-15 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.653 Å) | | 主引用文献 | A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo.
Nat.Chem.Biol., 19, 2023
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7XR3
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7XR2
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7XZO
 | | Formate-tetrahydrofolate ligase in complex with ATP | | 分子名称: | (R,R)-2,3-BUTANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Formate--tetrahydrofolate ligase, ... | | 著者 | Fang, C.L, Zhang, Y. | | 登録日 | 2022-06-03 | | 公開日 | 2023-06-07 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | | 主引用文献 | Identification of FtfL as a novel target of berberine in intestinal bacteria.
Bmc Biol., 21, 2023
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7XZN
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7XZP
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4PL6
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4NG9
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4KQ8
 | | Structure of Recombinant Human Cytochrome P450 Aromatase | | 分子名称: | 4-ANDROSTENE-3-17-DIONE, Cytochrome P450 19A1, PHOSPHATE ION, ... | | 著者 | Ghosh, D, Di Nardo, G, Griswold, J. | | 登録日 | 2013-05-14 | | 公開日 | 2013-08-21 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.29 Å) | | 主引用文献 | Structural basis for the functional roles of critical residues in human cytochrome p450 aromatase.
Biochemistry, 52, 2013
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