7XZP

Formate-tetrahydrofolate ligase in complex with berberine

Summary for 7XZP

• Entry DOI: 10.2210/pdb7xzp/pdb
• Descriptor: Formate--tetrahydrofolate ligase, BERBERINE, SULFATE ION, ... (5 entities in total)
• Functional Keywords: formate tetrahydrofolate ligase, berberine, ligase
• Biological source: Peptostreptococcus anaerobius
• Total number of polymer chains: 2
• Total formula weight: 123740.01

Authors

Fang, C.L.,Zhang, Y. (deposition date: 2022-06-03, release date: 2023-06-07, Last modification date: 2023-12-20)

Primary citation

Yan, J.,Fang, C.,Yang, G.,Li, J.,Liu, Y.,Zhang, L.,Yang, P.,Fang, J.,Gu, Y.,Zhang, Y.,Jiang, W.
Identification of FtfL as a novel target of berberine in intestinal bacteria.
Bmc Biol., 21:280-280, 2023

PubMed Abstract: Berberine (BBR) is a commonly used anti-intestinal inflammation drug, and its anti-cancer activity has been found recently. BBR can intervene and control malignant colorectal cancer (CRC) through intestinal microbes, but the direct molecular target and related mechanism are unclear. This study aimed to identify the target of BBR and dissect related mechanisms against the occurrence and development of CRC from the perspective of intestinal microorganisms.

PubMed: 38049785
DOI: 10.1186/s12915-023-01778-w

Experimental method

X-RAY DIFFRACTION (2.56 Å)