7XZN

Formate-tetrahydrofolate ligase from Peptostreptococcus anaerobius

Summary for 7XZN

Entry DOI	10.2210/pdb7xzn/pdb
Descriptor	Formate--tetrahydrofolate ligase, 1,2-ETHANEDIOL, TRIS(HYDROXYETHYL)AMINOMETHANE, ... (4 entities in total)
Functional Keywords	formate-tetrahydrofolate ligase, berberine, ligase
Biological source	Peptostreptococcus anaerobius
Total number of polymer chains	4
Total formula weight	243606.09
Authors	Fang, C.L.,Zhang, Y. (deposition date: 2022-06-03, release date: 2023-06-07, Last modification date: 2023-12-20)
Primary citation	Yan, J.,Fang, C.,Yang, G.,Li, J.,Liu, Y.,Zhang, L.,Yang, P.,Fang, J.,Gu, Y.,Zhang, Y.,Jiang, W. Identification of FtfL as a novel target of berberine in intestinal bacteria. Bmc Biol., 21:280-280, 2023 Cited by PubMed Abstract: Berberine (BBR) is a commonly used anti-intestinal inflammation drug, and its anti-cancer activity has been found recently. BBR can intervene and control malignant colorectal cancer (CRC) through intestinal microbes, but the direct molecular target and related mechanism are unclear. This study aimed to identify the target of BBR and dissect related mechanisms against the occurrence and development of CRC from the perspective of intestinal microorganisms. PubMed: 38049785 DOI: 10.1186/s12915-023-01778-w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.04 Å)

Structure validation