5U6J
Factor VIIa in complex with the inhibitor 3-{[(2R)-17-ethyl-4-methyl-3,12-dioxo-7-[(propan-2-yl)sulfonyl]-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaen-2-yl]amino}benzamide
Summary for 5U6J
Entry DOI | 10.2210/pdb5u6j/pdb |
Descriptor | Coagulation factor VII Heavy Chain, Coagulation factor VII Light Chain, 3-{[(2R)-17-ethyl-4-methyl-3,12-dioxo-7-[(propan-2-yl)sulfonyl]-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaen-2-yl]amino}benzamide, ... (7 entities in total) |
Functional Keywords | glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium- binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted: P08709 P08709 |
Total number of polymer chains | 2 |
Total formula weight | 35335.31 |
Authors | |
Primary citation | Wurtz, N.R.,Parkhurst, B.L.,DeLucca, I.,Glunz, P.W.,Jiang, W.,Zhang, X.,Cheney, D.L.,Bozarth, J.M.,Rendina, A.R.,Wei, A.,Harper, T.,Luettgen, J.M.,Wu, Y.,Wong, P.C.,Seiffert, D.A.,Wexler, R.R.,Priestley, E.S. Neutral macrocyclic factor VIIa inhibitors. Bioorg. Med. Chem. Lett., 27:2650-2654, 2017 Cited by PubMed: 28460818DOI: 10.1016/j.bmcl.2017.04.008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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