5U6J

Factor VIIa in complex with the inhibitor 3-{[(2R)-17-ethyl-4-methyl-3,12-dioxo-7-[(propan-2-yl)sulfonyl]-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaen-2-yl]amino}benzamide

Summary for 5U6J

• Entry DOI: 10.2210/pdb5u6j/pdb
• Descriptor: Coagulation factor VII Heavy Chain, Coagulation factor VII Light Chain, 3-{[(2R)-17-ethyl-4-methyl-3,12-dioxo-7-[(propan-2-yl)sulfonyl]-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaen-2-yl]amino}benzamide, ... (7 entities in total)
• Functional Keywords: glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium- binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted: P08709 P08709
• Total number of polymer chains: 2
• Total formula weight: 35335.31

Authors

Wei, A. (deposition date: 2016-12-08, release date: 2017-05-10, Last modification date: 2023-10-04)

• Primary citation: Wurtz, N.R.,Parkhurst, B.L.,DeLucca, I.,Glunz, P.W.,Jiang, W.,Zhang, X.,Cheney, D.L.,Bozarth, J.M.,Rendina, A.R.,Wei, A.,Harper, T.,Luettgen, J.M.,Wu, Y.,Wong, P.C.,Seiffert, D.A.,Wexler, R.R.,Priestley, E.S.; Neutral macrocyclic factor VIIa inhibitors.; Bioorg. Med. Chem. Lett., 27:2650-2654, 2017; PubMed: 28460818; DOI: 10.1016/j.bmcl.2017.04.008

Experimental method

X-RAY DIFFRACTION (2.3 Å)