5L2Z

Factor VIIa in complex with the inhibitor 1-[(2R,15R)-2-[(1-amino-4-fluoroisoquinolin-6-yl)amino]-4,15,17-trimethyl-3,12-dioxo-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaen-7-yl]cyclohexane-1-carboxylic acid

Summary for 5L2Z

• Entry DOI: 10.2210/pdb5l2z/pdb
• Descriptor: Coagulation factor VII (Heavy Chain), Coagulation factor VII (Light Chain), 1-[(2R,15R)-2-[(1-amino-4-fluoroisoquinolin-6-yl)amino]-4,15,17-trimethyl-3,12-dioxo-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaen-7-yl]cyclohexane-1-carboxylic acid, ... (7 entities in total)
• Functional Keywords: glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted: P08709 P08709
• Total number of polymer chains: 2
• Total formula weight: 35656.65

Authors

Wei, A. (deposition date: 2016-08-02, release date: 2016-09-28, Last modification date: 2023-10-04)

• Primary citation: Ladziata, V.U.,Glunz, P.W.,Zou, Y.,Zhang, X.,Jiang, W.,Jacutin-Porte, S.,Cheney, D.L.,Wei, A.,Luettgen, J.M.,Harper, T.M.,Wong, P.C.,Seiffert, D.,Wexler, R.R.,Priestley, E.S.; Synthesis and P1' SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors.; Bioorg.Med.Chem.Lett., 26:5051-5057, 2016; PubMed: 27612545; DOI: 10.1016/j.bmcl.2016.08.088

Experimental method

X-RAY DIFFRACTION (1.79 Å)