4GL5

Structure of human placental aromatase complexed with designed inhibitor HDDG029 (compound 4)

Summary for 4GL5

Entry DOI	10.2210/pdb4gl5/pdb
Related	3EQM 3S79 3S7S 4GL7
Descriptor	Cytochrome P450 19A1, PROTOPORPHYRIN IX CONTAINING FE, (6alpha,8alpha)-6-(but-2-yn-1-yloxy)androsta-1,4-diene-3,17-dione (3 entities in total)
Functional Keywords	oxidoreductase, estrogen synthetase, cytochrome p450 reductase, er membrane, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Membrane; Peripheral membrane protein: P11511
Total number of polymer chains	1
Total formula weight	58923.82
Authors	Ghosh, D. (deposition date: 2012-08-13, release date: 2012-09-12, Last modification date: 2024-02-28)
Primary citation	Ghosh, D.,Lo, J.,Morton, D.,Valette, D.,Xi, J.,Griswold, J.,Hubbell, S.,Egbuta, C.,Jiang, W.,An, J.,Davies, H.M. Novel aromatase inhibitors by structure-guided design. J.Med.Chem., 55:8464-8476, 2012 Cited by PubMed: 22951074 DOI: 10.1021/jm300930n PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.48 Å)

Structure validation