7E3L
| Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 58G6 heavy chain, 58G6 light chain, ... | 著者 | Guo, H, Li, T, Liu, F, Gao, Y, Ji, X, Yang, H. | 登録日 | 2021-02-09 | 公開日 | 2021-09-15 | 最終更新日 | 2022-03-02 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants. Nat Commun, 12, 2021
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7E3K
| Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants | 分子名称: | 13G9 heavy chain, 13G9 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Guo, H, Li, T, Liu, F, Gao, Y, Ji, X, Yang, H. | 登録日 | 2021-02-09 | 公開日 | 2021-09-15 | 最終更新日 | 2022-03-02 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants. Nat Commun, 12, 2021
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5FAD
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4YSJ
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5GMP
| Crystal structure of EGFR 696-1022 T790M in complex with XTF-262 | 分子名称: | Epidermal growth factor receptor, N-[3-[2-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-5-methyl-7-oxidanylidene-pyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide | 著者 | Yan, X.E, Yun, C.H. | 登録日 | 2016-07-14 | 公開日 | 2017-06-28 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.797 Å) | 主引用文献 | A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFR(L858R/T790M) mutant with improved pharmacokinetic properties. Eur J Med Chem, 126, 2017
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7EOD
| MITF HLHLZ Delta AKE | 分子名称: | GLYCEROL, Isoform M1 of Microphthalmia-associated transcription factor | 著者 | Li, P, Liu, Z, Fang, P, Wang, J. | 登録日 | 2021-04-22 | 公開日 | 2022-04-27 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. Cell Res., 33, 2023
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7FAH
| Immune complex of head region of CA09 HA and neutralizing antibody 12H5 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | 著者 | Li, T.T, Xue, W.H, Gu, Y, Li, S.W. | 登録日 | 2021-07-06 | 公開日 | 2022-07-06 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.151 Å) | 主引用文献 | Identification of a cross-neutralizing antibody that targets the receptor binding site of H1N1 and H5N1 influenza viruses. Nat Commun, 13, 2022
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5FA8
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3TVV
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3NEF
| High-resolution pyrabactin-bound PYL1 structure | 分子名称: | 4-bromo-N-(pyridin-2-ylmethyl)naphthalene-1-sulfonamide, Abscisic acid receptor PYL1 | 著者 | Yan, N. | 登録日 | 2010-06-08 | 公開日 | 2010-06-16 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Functional mechanism of the ABA agonist pyrabactin J.Biol.Chem., 285, 2010
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5GJ4
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7C2L
| S protein of SARS-CoV-2 in complex bound with 4A8 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yan, R.H, Zhang, Y.Y, Guo, Y.Y, Li, Y.N, Xia, L, Zhou, Q. | 登録日 | 2020-05-08 | 公開日 | 2020-07-01 | 最終更新日 | 2021-02-17 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2. Science, 369, 2020
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3NEG
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7FAE
| S protein of SARS-CoV-2 in complex bound with P36-5D2(state2) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, P36-5D2 heavy chain, ... | 著者 | Zhang, L, Wang, X, Shan, S, Zhang, S. | 登録日 | 2021-07-06 | 公開日 | 2021-12-22 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.65 Å) | 主引用文献 | A Potent and Protective Human Neutralizing Antibody Against SARS-CoV-2 Variants. Front Immunol, 12, 2021
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7FAF
| S protein of SARS-CoV-2 in complex bound with P36-5D2 (state1) | 分子名称: | P36-5D2 heavy chain, P36-5D2 light chain, Spike glycoprotein | 著者 | Zhang, L, Wang, X, Zhang, S, Shan, S. | 登録日 | 2021-07-06 | 公開日 | 2021-12-22 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.69 Å) | 主引用文献 | A Potent and Protective Human Neutralizing Antibody Against SARS-CoV-2 Variants. Front Immunol, 12, 2021
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7CKK
| Structural complex of FTO bound with Dac51 | 分子名称: | 2-{[2,6-dichloro-4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]amino}-N-hydroxybenzamide, Alpha-ketoglutarate-dependent dioxygenase FTO, N-OXALYLGLYCINE | 著者 | Yang, C, Gan, J. | 登録日 | 2020-07-17 | 公開日 | 2021-07-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance. Cell Metab., 33, 2021
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3P0H
| Leishmania major Tyrosyl-tRNA synthetase in complex with fisetin, cubic crystal form | 分子名称: | 3,7,3',4'-TETRAHYDROXYFLAVONE, Tyrosyl-tRNA synthetase | 著者 | Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP) | 登録日 | 2010-09-28 | 公開日 | 2011-03-23 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The Double-Length Tyrosyl-tRNA Synthetase from the Eukaryote Leishmania major Forms an Intrinsically Asymmetric Pseudo-Dimer. J.Mol.Biol., 409, 2011
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4CCJ
| 60S ribosomal protein L8 histidine hydroxylase (NO66) in apo form | 分子名称: | 1,2-ETHANEDIOL, BIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE NO66 | 著者 | Chowdhury, R, Ge, W, Clifton, I.J, Schofield, C.J. | 登録日 | 2013-10-23 | 公開日 | 2014-05-14 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Ribosomal oxygenases are structurally conserved from prokaryotes to humans. Nature, 510, 2014
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4CCO
| 60S ribosomal protein L8 histidine hydroxylase (NO66 S373C) in complex with Mn(II), N-oxalylglycine (NOG) and 60S ribosomal protein L8 (RPL8 G214C) peptide fragment (complex-3) | 分子名称: | 1,2-ETHANEDIOL, 60S RIBOSOMAL PROTEIN L8, BIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE NO66, ... | 著者 | Chowdhury, R, Schofield, C.J. | 登録日 | 2013-10-23 | 公開日 | 2014-05-14 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Ribosomal oxygenases are structurally conserved from prokaryotes to humans. Nature, 510, 2014
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4G1F
| Crystal Structure of human Dipeptidyl Peptidase IV in complex with a pyridopyrimidinedione analogue | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-amino-6-(aminomethyl)-5-(2-bromophenyl)-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione, ... | 著者 | Skene, R.J, Gwaltney, S.L. | 登録日 | 2012-07-10 | 公開日 | 2013-02-27 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
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7D8S
| MITF bHLHLZ apo structure | 分子名称: | Microphthalmia-associated transcription factor,Methionyl-tRNA synthetase beta subunit, SULFATE ION | 著者 | Guo, M, Fang, P, Wang, J. | 登録日 | 2020-10-09 | 公開日 | 2021-10-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. Cell Res., 33, 2023
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3P0J
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6JBX
| Crystal structure of Streptococcus pneumoniae FabT in complex with DNA | 分子名称: | DNA (5'-D(*AP*AP*TP*AP*GP*TP*TP*TP*GP*AP*CP*TP*GP*TP*CP*AP*AP*AP*TP*TP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*AP*AP*TP*TP*TP*GP*AP*CP*AP*GP*TP*CP*AP*AP*AP*CP*TP*AP*TP*T)-3'), Fatty acid biosynthesis transcriptional regulator, ... | 著者 | Zuo, G, Chen, Z.P, Li, Q, Zhou, C.Z. | 登録日 | 2019-01-27 | 公開日 | 2019-07-24 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural insights into repression of the Pneumococcal fatty acid synthesis pathway by repressor FabT and co-repressor acyl-ACP. Febs Lett., 593, 2019
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8JY6
| Structure of TbAQP2 in complex with anti-trypanosomatid drug melarsoprol | 分子名称: | Aquaglyceroporin 2, [(4~{R})-2-[4-[[4,6-bis(azanyl)-1,3,5-triazin-2-yl]amino]phenyl]-1,3,2-dithiarsolan-4-yl]methanol | 著者 | Chen, W, Wang, C. | 登録日 | 2023-07-03 | 公開日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Structural insights into drug transport by an aquaglyceroporin. Nat Commun, 15, 2024
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8JY8
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