3TG3
 
 | | Crystal structure of the MAPK binding domain of MKP7 | | 分子名称: | 1,2-ETHANEDIOL, Dual specificity protein phosphatase 16 | | 著者 | Zhang, Y.Y, Liu, X, Wu, J.W, Wang, Z.X. | | 登録日 | 2011-08-17 | | 公開日 | 2012-03-14 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.675 Å) | | 主引用文献 | A Distinct Interaction Mode Revealed by the Crystal Structure of the Kinase p38alpha with the MAPK Binding Domain of the Phosphatase MKP5.
Sci.Signal., 4, 2011
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8GL6
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8GLJ
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8GLK
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8GLN
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8GL8
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8GLM
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7TZO
 | | The apo structure of human mTORC2 complex | | 分子名称: | Rapamycin-insensitive companion of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex 2 subunit MAPKAP1, ... | | 著者 | Yu, Z, Chen, J, Pearce, D. | | 登録日 | 2022-02-16 | | 公開日 | 2023-01-11 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | | 主引用文献 | Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt.
J.Biol.Chem., 298, 2022
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7W3R
 | | USP34 catalytic domain | | 分子名称: | Ubiquitin carboxyl-terminal hydrolase 34, ZINC ION | | 著者 | Xu, G.L, Ming, Z.H. | | 登録日 | 2021-11-26 | | 公開日 | 2022-06-01 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | Structural Insights into the Catalytic Mechanism and Ubiquitin Recognition of USP34.
J.Mol.Biol., 434, 2022
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7W3U
 | | USP34 catalytic domain in complex with UbPA | | 分子名称: | Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 34, ZINC ION, ... | | 著者 | Xu, G.L, Ming, Z.H. | | 登録日 | 2021-11-26 | | 公開日 | 2022-06-01 | | 最終更新日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (3.13 Å) | | 主引用文献 | Structural Insights into the Catalytic Mechanism and Ubiquitin Recognition of USP34.
J.Mol.Biol., 434, 2022
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7U9J
 | | Crystal structure of Mesothelin-207 fragment | | 分子名称: | GLYCEROL, Isoform 3 of Mesothelin, SULFATE ION | | 著者 | Zhan, J, Esser, L, Lin, D, Tang, W.K, Xia, D. | | 登録日 | 2022-03-10 | | 公開日 | 2023-02-01 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies.
Cancer Res Commun, 3, 2023
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7UED
 | | Crystal structure of full length mesothelin bound with MORAb-009 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Isoform 4 of Mesothelin, ... | | 著者 | Zhan, J, Esser, L, Lin, D, Tang, W.K, Xia, D. | | 登録日 | 2022-03-21 | | 公開日 | 2023-02-01 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies.
Cancer Res Commun, 3, 2023
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7VGI
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7VGJ
 | | Cryo-EM structure of the human P4-type flippase ATP8B1-CDC50A in the auto-inhibited E2Pi-PS state | | 分子名称: | Cell cycle control protein 50A, O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine, Phospholipid-transporting ATPase IC | | 著者 | Chen, M.T, Chen, Y, Chen, Z.P, Zhou, C.Z, Hou, W.T, Chen, Y. | | 登録日 | 2021-09-16 | | 公開日 | 2022-03-30 | | 最終更新日 | 2022-10-12 | | 実験手法 | ELECTRON MICROSCOPY (3.98 Å) | | 主引用文献 | Structural insights into the activation of autoinhibited human lipid flippase ATP8B1 upon substrate binding.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7VGH
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7VW5
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7VB4
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7XJP
 | | Cryo-EM structure of EDS1 and SAG101 with ATP-APDR | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ADENOSINE-5-DIPHOSPHORIBOSE, ISOPROPYL ALCOHOL, ... | | 著者 | Huang, S.J, Jia, A.L, Han, Z.F, Chai, J.J. | | 登録日 | 2022-04-18 | | 公開日 | 2022-07-20 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.71 Å) | | 主引用文献 | TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity.
Science, 377, 2022
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7C4D
 | | Marine microorganism esterase | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Putative esterase, ... | | 著者 | Zhu, C.H, Wu, Y.K, Isupov, M.N. | | 登録日 | 2020-05-16 | | 公開日 | 2021-05-26 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | Structural Insights into a Novel Esterase from the East Pacific Rise and Its Improved Thermostability by a Semirational Design.
J.Agric.Food Chem., 69, 2021
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7DN9
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7DN8
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7DYR
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7F0S
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7C4O
 | | Solution structure of the Orange domain from human protein HES1 | | 分子名称: | Transcription factor HES-1 | | 著者 | Fan, J.S, Nayak, A, Swaminathan, K. | | 登録日 | 2020-05-18 | | 公開日 | 2021-05-19 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Induction of Transcriptional Inhibitor Hairy and Enhancer of Split Homolog-1 and the Related Repression of Tumor-Suppressor Thioredoxin-Interacting Protein Are Important Components of Cell-Transformation Program Imposed by Oncogenic Kinase Nucleophosmin-Anaplastic Lymphoma Kinase.
Am J Pathol, 2022
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7DNJ
 | | K63-polyUb MDA5CARDs complex | | 分子名称: | Interferon-induced helicase C domain-containing protein 1, Ubiquitin | | 著者 | Song, B, Chen, Y, Luo, D.H, Zheng, J. | | 登録日 | 2020-12-09 | | 公開日 | 2021-10-13 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains.
Immunity, 54, 2021
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