7VGJ

Cryo-EM structure of the human P4-type flippase ATP8B1-CDC50A in the auto-inhibited E2Pi-PS state

Summary for 7VGJ

Entry DOI	10.2210/pdb7vgj/pdb
EMDB information	31971
Descriptor	Phospholipid-transporting ATPase IC, Cell cycle control protein 50A, O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine (3 entities in total)
Functional Keywords	auto-inhibited, phosphorylated, lipid flippase, lipid transport, translocase-lipid transport complex, translocase/lipid transport
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	191096.38
Authors	Chen, M.T.,Chen, Y.,Chen, Z.P.,Zhou, C.Z.,Hou, W.T.,Chen, Y. (deposition date: 2021-09-16, release date: 2022-03-30, Last modification date: 2022-10-12)
Primary citation	Cheng, M.T.,Chen, Y.,Chen, Z.P.,Liu, X.,Zhang, Z.,Chen, Y.,Hou, W.T.,Zhou, C.Z. Structural insights into the activation of autoinhibited human lipid flippase ATP8B1 upon substrate binding. Proc.Natl.Acad.Sci.USA, 119:e2118656119-e2118656119, 2022 Cited by PubMed: 35349344 DOI: 10.1073/pnas.2118656119 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.98 Å)

Structure validation