8U4E
| Cryo-EM structure of long form insulin receptor (IR-B) with three IGF2 bound, asymmetric conformation. | 分子名称: | Insulin receptor, Insulin-like growth factor II | 著者 | An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. | 登録日 | 2023-09-10 | 公開日 | 2024-03-27 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Activation of the insulin receptor by insulin-like growth factor 2. Nat Commun, 15, 2024
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8U4B
| Cryo-EM structure of long form insulin receptor (IR-B) in the apo state | 分子名称: | Insulin receptor | 著者 | An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. | 登録日 | 2023-09-10 | 公開日 | 2024-03-27 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Activation of the insulin receptor by insulin-like growth factor 2. Nat Commun, 15, 2024
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8U4C
| Cryo-EM structure of long form insulin receptor (IR-B) with four IGF2 bound, symmetric conformation. | 分子名称: | Insulin receptor, Insulin-like growth factor II | 著者 | An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. | 登録日 | 2023-09-10 | 公開日 | 2024-03-27 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Activation of the insulin receptor by insulin-like growth factor 2. Nat Commun, 15, 2024
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7W1S
| Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with neutralizing nanobody Nb-007 | 分子名称: | Nanobody Nb-007, Spike protein S1 | 著者 | Yang, J, Lin, S, Sun, H.L, Lu, G.W. | 登録日 | 2021-11-20 | 公開日 | 2022-06-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | 主引用文献 | A Potent Neutralizing Nanobody Targeting the Spike Receptor-Binding Domain of SARS-CoV-2 and the Structural Basis of Its Intimate Binding. Front Immunol, 13, 2022
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7W0P
| Cryo-EM structure of a GPCR-Gi complex with peptide | 分子名称: | Apelin receptor early endogenous ligand, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Xu, F, Yue, Y, Liu, L.E, Wu, L.J, Hanson, M. | 登録日 | 2021-11-18 | 公開日 | 2022-07-27 | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | 主引用文献 | Structural insight into apelin receptor-G protein stoichiometry. Nat.Struct.Mol.Biol., 29, 2022
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8JAJ
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8JAN
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8J00
| Human KCNQ2-CaM in complex with CBD | 分子名称: | Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 2, cannabidiol | 著者 | Ma, D, Li, X, Guo, J. | 登録日 | 2023-04-09 | 公開日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Ligand activation mechanisms of human KCNQ2 channel. Nat Commun, 14, 2023
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8J01
| Human KCNQ2-CaM in complex with CBD and PIP2 | 分子名称: | Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 2, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ... | 著者 | Ma, D, Li, X, Guo, J. | 登録日 | 2023-04-09 | 公開日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Ligand activation mechanisms of human KCNQ2 channel. Nat Commun, 14, 2023
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8J02
| Human KCNQ2(F104A)-CaM-PIP2-CBD complex in state II | 分子名称: | Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 2, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ... | 著者 | Ma, D, Li, X, Guo, J. | 登録日 | 2023-04-09 | 公開日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Ligand activation mechanisms of human KCNQ2 channel. Nat Commun, 14, 2023
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8W4U
| human KCNQ2-CaM in complex with PIP2 and HN37 | 分子名称: | Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 2, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ... | 著者 | Ma, D, Li, X, Guo, J. | 登録日 | 2023-08-25 | 公開日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Ligand activation mechanisms of human KCNQ2 channel. Nat Commun, 14, 2023
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8UWL
| 5-HT2AR bound to Lisuride in complex with a mini-Gq protein and an active-state stabilizing single-chain variable fragment (scFv16) obtained by cryo-electron microscopy (cryoEM) | 分子名称: | 5-hydroxytryptamine receptor 2A, G protein subunit q (Gi2-mini-Gq chimera), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Barros-Alvarez, X, Kim, K, Panova, O, Roth, B.L, Skiniotis, G. | 登録日 | 2023-11-06 | 公開日 | 2024-05-29 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | AlphaFold2 structures guide prospective ligand discovery. Science, 384, 2024
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7Y9N
| an engineered 5-helix bundle derived from SARS-CoV-2 S2 in complex with HR2P | 分子名称: | SARS-coV-2 S2 subunit, Spike protein S2',5HB-H2 | 著者 | Lu, G.W, Lin, X, Guo, L.Y, Lin, S. | 登録日 | 2022-06-25 | 公開日 | 2022-08-17 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.885 Å) | 主引用文献 | An engineered 5-helix bundle derived from SARS-CoV-2 S2 pre-binds sarbecoviral spike at both serological- and endosomal-pH to inhibit virus entry. Emerg Microbes Infect, 11, 2022
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7W0N
| Cryo-EM structure of a dimeric GPCR-Gi complex with peptide | 分子名称: | Apelin receptor early endogenous ligand, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Xu, F, Yue, Y, Wu, L.J, Liu, L.E, Hanson, M. | 登録日 | 2021-11-18 | 公開日 | 2022-07-27 | 実験手法 | ELECTRON MICROSCOPY (4.21 Å) | 主引用文献 | Structural insight into apelin receptor-G protein stoichiometry. Nat.Struct.Mol.Biol., 29, 2022
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7W0L
| Cryo-EM structure of a dimeric GPCR-Gi complex with small molecule | 分子名称: | (1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yue, Y, Liu, L.E, Wu, L.J, Xu, F, Hanson, M. | 登録日 | 2021-11-18 | 公開日 | 2022-07-27 | 最終更新日 | 2022-08-03 | 実験手法 | ELECTRON MICROSCOPY (3.57 Å) | 主引用文献 | Structural insight into apelin receptor-G protein stoichiometry. Nat.Struct.Mol.Biol., 29, 2022
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7W0O
| Cryo-EM structure of a monomeric GPCR-Gi complex with peptide | 分子名称: | Apelin receptor early endogenous ligand, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Xu, F, Yue, Y, Liu, L.E, Wu, L.J, Hanson, M. | 登録日 | 2021-11-18 | 公開日 | 2022-07-27 | 実験手法 | ELECTRON MICROSCOPY (3.78 Å) | 主引用文献 | Structural insight into apelin receptor-G protein stoichiometry. Nat.Struct.Mol.Biol., 29, 2022
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7W0M
| Cryo-EM structure of a monomeric GPCR-Gi complex with small molecule | 分子名称: | (1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Xu, F, Yue, Y, Liu, L.E, Wu, L.J, Hanson, M. | 登録日 | 2021-11-18 | 公開日 | 2022-07-27 | 実験手法 | ELECTRON MICROSCOPY (3.71 Å) | 主引用文献 | Structural insight into apelin receptor-G protein stoichiometry. Nat.Struct.Mol.Biol., 29, 2022
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8VJB
| Cryo-EM structure of short form insulin receptor (IR-A) with four IGF2 bound, symmetric conformation. | 分子名称: | Insulin-like growth factor II, Isoform Short of Insulin receptor | 著者 | An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. | 登録日 | 2024-01-06 | 公開日 | 2024-03-27 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Activation of the insulin receptor by insulin-like growth factor 2. Nat Commun, 15, 2024
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8VJC
| Cryo-EM structure of short form insulin receptor (IR-A) with three IGF2 bound, asymmetric conformation. | 分子名称: | Insulin-like growth factor II, Isoform Short of Insulin receptor | 著者 | An, W, Hall, C, Li, J, Huang, A, Wu, J, Park, J, Bai, X.C, Choi, E. | 登録日 | 2024-01-06 | 公開日 | 2024-03-27 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Activation of the insulin receptor by insulin-like growth factor 2. Nat Commun, 15, 2024
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8IF2
| Crystal structure of the receptor binding domain of SARS-CoV-2 Omicron BQ.1.1 variant spike protein in complex with its receptor ACE2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... | 著者 | Kimura, K, Suzuki, T, Hashiguchi, T. | 登録日 | 2023-02-17 | 公開日 | 2023-05-17 | 最終更新日 | 2023-05-24 | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | 主引用文献 | Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant. Nat Commun, 14, 2023
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7XDX
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7XDV
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7XDW
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7XDY
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8IZY
| Human KCNQ2-CaM in complex with HN37 | 分子名称: | Potassium voltage-gated channel subfamily KQT member 2, methyl N-[4-[(4-fluorophenyl)methyl-prop-2-ynyl-amino]-2,6-dimethyl-phenyl]carbamate | 著者 | Ma, D, Li, X, Guo, J. | 登録日 | 2023-04-09 | 公開日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Ligand activation mechanisms of human KCNQ2 channel. Nat Commun, 14, 2023
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