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7Y9N

an engineered 5-helix bundle derived from SARS-CoV-2 S2 in complex with HR2P

Summary for 7Y9N
Entry DOI10.2210/pdb7y9n/pdb
DescriptorSpike protein S2',5HB-H2, SARS-coV-2 S2 subunit (3 entities in total)
Functional Keywords5hb, virus protein/inhibitor, virus protein-inhibitor complex
Biological sourceSevere acute respiratory syndrome coronavirus 2
More
Total number of polymer chains2
Total formula weight30361.70
Authors
Lu, G.W.,Lin, X.,Guo, L.Y.,Lin, S. (deposition date: 2022-06-25, release date: 2022-08-17, Last modification date: 2023-11-29)
Primary citationLin, X.,Guo, L.,Lin, S.,Chen, Z.,Yang, F.,Yang, J.,Wang, L.,Wen, A.,Duan, Y.,Zhang, X.,Dai, Y.,Yin, K.,Yuan, X.,Yu, C.,He, B.,Cao, Y.,Dong, H.,Li, J.,Zhao, Q.,Lu, G.
An engineered 5-helix bundle derived from SARS-CoV-2 S2 pre-binds sarbecoviral spike at both serological- and endosomal-pH to inhibit virus entry.
Emerg Microbes Infect, 11:1920-1935, 2022
Cited by
PubMed: 35757908
DOI: 10.1080/22221751.2022.2095308
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.885 Å)
Structure validation

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