8W4U

human KCNQ2-CaM in complex with PIP2 and HN37

Summary for 8W4U

• Entry DOI: 10.2210/pdb8w4u/pdb
• EMDB information: 37270
• Descriptor: Potassium voltage-gated channel subfamily KQT member 2, Calmodulin-1, methyl N-[4-[(4-fluorophenyl)methyl-prop-2-ynyl-amino]-2,6-dimethyl-phenyl]carbamate, ... (4 entities in total)
• Functional Keywords: potassium voltage-gated channel, hn37, pip2, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 366269.26

Authors

Ma, D.,Li, X.,Guo, J. (deposition date: 2023-08-25, release date: 2023-12-13)

• Primary citation: Ma, D.,Zheng, Y.,Li, X.,Zhou, X.,Yang, Z.,Zhang, Y.,Wang, L.,Zhang, W.,Fang, J.,Zhao, G.,Hou, P.,Nan, F.,Yang, W.,Su, N.,Gao, Z.,Guo, J.; Ligand activation mechanisms of human KCNQ2 channel.; Nat Commun, 14:6632-6632, 2023; PubMed: 37857637; DOI: 10.1038/s41467-023-42416-x

Experimental method

ELECTRON MICROSCOPY (3.3 Å)