6JJF
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![BU of 6jjf by Molmil](/molmil-images/mine/6jjf) | Crystal structure of a two-quartet DNA mixed-parallel/antiparallel G-quadruplex | 分子名称: | COBALT HEXAMMINE(III), DNA (5'-D(*GP*GP*CP*TP*CP*GP*GP*CP*GP*GP*CP*GP*GP*A)-3'), POTASSIUM ION, ... | 著者 | Zhang, Y.S, EI Omari, K, Duman, R, Wagner, A, Parkinson, G.N, Wei, D.G. | 登録日 | 2019-02-25 | 公開日 | 2020-02-26 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Native de novo structural determinations of non-canonical nucleic acid motifs by X-ray crystallography at long wavelengths. Nucleic Acids Res., 48, 2020
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7Y56
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7Y57
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6IKM
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![BU of 6ikm by Molmil](/molmil-images/mine/6ikm) | Crystal structure of SpuE-Spermidine in complex with ScFv5 | 分子名称: | Polyamine transport protein, SPERMIDINE, SULFATE ION, ... | 著者 | Wu, D, Sun, X. | 登録日 | 2018-10-16 | 公開日 | 2019-12-25 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3.398 Å) | 主引用文献 | A Potent Anti-SpuE Antibody Allosterically Inhibits Type III Secretion System and Attenuates Virulence of Pseudomonas Aeruginosa. J.Mol.Biol., 431, 2019
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8K6Q
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![BU of 8k6q by Molmil](/molmil-images/mine/8k6q) | Crystal structure of HOIL-1L LTM domain | 分子名称: | RanBP-type and C3HC4-type zinc finger-containing protein 1 | 著者 | Yan, Z, Pan, L.F. | 登録日 | 2023-07-25 | 公開日 | 2024-07-03 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Mechanistic insights into the homo-dimerization of HOIL-1L and SHARPIN. Biochem.Biophys.Res.Commun., 689, 2023
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8K6P
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7XQV
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![BU of 7xqv by Molmil](/molmil-images/mine/7xqv) | The complex of nanobody Rh57 binding to GTP-bound RhoA active form | 分子名称: | ALANINE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | 著者 | Zhang, Y.R, Liu, R, Ding, Y. | 登録日 | 2022-05-09 | 公開日 | 2022-07-13 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | 主引用文献 | Structural insights into the binding of nanobody Rh57 to active RhoA-GTP. Biochem.Biophys.Res.Commun., 616, 2022
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7WFY
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7YIR
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7YIS
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![BU of 7yis by Molmil](/molmil-images/mine/7yis) | Crystal structure of N-terminal PH domain of ARAP3 protein in complex with inositol 1,3,4,5-tetrakisphosphate | 分子名称: | (2R)-3-{[(S)-{[(2S,3R,5S,6S)-2,6-DIHYDROXY-3,4,5-TRIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-(1-HYDROXY BUTOXY)PROPYL BUTYRATE, Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 | 著者 | Zhang, Y.J, Liu, Y.R, Wu, B. | 登録日 | 2022-07-18 | 公開日 | 2023-05-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structural Insights Uncover the Specific Phosphoinositide Recognition by the PH1 Domain of Arap3. Int J Mol Sci, 24, 2023
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7WF6
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![BU of 7wf6 by Molmil](/molmil-images/mine/7wf6) | Crystal structure of SNX13 RGS domain | 分子名称: | CHLORIDE ION, Sorting nexin-13 | 著者 | Xu, J, Zhu, J, Liu, J. | 登録日 | 2021-12-26 | 公開日 | 2022-10-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Structural Studies Reveal Unique Non-canonical Regulators of G Protein Signaling Homology (RH) Domains in Sorting Nexins. J.Mol.Biol., 434, 2022
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7E16
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7FEW
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7FF0
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4W6E
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![BU of 4w6e by Molmil](/molmil-images/mine/4w6e) | Human Tankyrase 1 with small molecule inhibitor | 分子名称: | 2-(4-{6-[(3S)-3,4-dimethylpiperazin-1-yl]-4-methylpyridin-3-yl}phenyl)-8-(hydroxymethyl)quinazolin-4(3H)-one, Tankyrase-1, ZINC ION | 著者 | Kazmirski, S.L, Johannes, J, Boriack-Sjodin, P.A, Howard, T. | 登録日 | 2014-08-20 | 公開日 | 2015-05-13 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology. Acs Med.Chem.Lett., 6, 2015
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6RAV
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![BU of 6rav by Molmil](/molmil-images/mine/6rav) | Complement factor B protease domain in complex with the reversible inhibitor 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic acid | 分子名称: | 4-[(2~{S},4~{S})-4-ethoxy-1-[(5-methoxy-7-methyl-1~{H}-indol-4-yl)methyl]piperidin-2-yl]benzoic acid, Complement factor B, SULFATE ION, ... | 著者 | Adams, C.M, Sellner, H, Ehara, T, Mac Sweeney, A, Crowley, M, Anderson, K, Karki, R, Mainolfi, N, Valeur, E, Sirockin, F, Gerhartz, B, Erbel, P, Hughes, N, Smith, T.M, Cumin, F, Argikar, U, Mogi, M, Sedrani, R, Wiesmann, C, Jaffee, B, Maibaum, J, Flohr, S, Harrison, R, Eder, J. | 登録日 | 2019-04-08 | 公開日 | 2019-04-17 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Small-molecule factor B inhibitor for the treatment of complement-mediated diseases. Proc.Natl.Acad.Sci.USA, 116, 2019
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8BNS
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6QSX
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![BU of 6qsx by Molmil](/molmil-images/mine/6qsx) | Complement factor B protease domain in complex with the reversible inhibitor ((2S,4S)-1-((5,7-dimethyl-1H-indol-4-yl)methyl)-4-methoxypiperidin-2-yl)methanol. | 分子名称: | Complement factor B, SULFATE ION, ZINC ION, ... | 著者 | Adams, C.M, Sellner, H, Ehara, T, Mac Sweeney, A, Crowley, M, Anderson, K, Karki, R, Mainolfi, N, Valeur, E, Sirockin, F, Gerhartz, B, Erbel, P, Hughes, N, Smith, T.M, Cumin, F, Argikar, U, Mogi, M, Sedrani, R, Wiesmann, C, Jaffee, B, Maibaum, J, Flohr, S, Harrison, R, Eder, J. | 登録日 | 2019-02-22 | 公開日 | 2019-03-27 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Small-molecule factor B inhibitor for the treatment of complement-mediated diseases. Proc.Natl.Acad.Sci.USA, 116, 2019
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5E9A
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6XF6
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![BU of 6xf6 by Molmil](/molmil-images/mine/6xf6) | Cryo-EM structure of a biotinylated SARS-CoV-2 spike probe in the prefusion state (1 RBD up) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Cerutti, G, Gorman, J, Kwong, P.D, Shapiro, L. | 登録日 | 2020-06-15 | 公開日 | 2020-09-02 | 最終更新日 | 2020-12-02 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes. SSRN, 2020
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6XF5
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![BU of 6xf5 by Molmil](/molmil-images/mine/6xf5) | Cryo-EM structure of a biotinylated SARS-CoV-2 spike probe in the prefusion state (RBDs down) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Cerutti, G, Gorman, J, Kwong, P.D, Shapiro, L. | 登録日 | 2020-06-15 | 公開日 | 2020-09-02 | 最終更新日 | 2020-12-02 | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | 主引用文献 | Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes. SSRN, 2020
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6R8X
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4W5S
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![BU of 4w5s by Molmil](/molmil-images/mine/4w5s) | Tankyrase in complex with compound | 分子名称: | 8-(hydroxymethyl)-2-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]quinazolin-4(3H)-one, GLYCEROL, Tankyrase-1, ... | 著者 | Johannes, J, Kazmirski, S.L, Boriack-Sjodin, P.A, Howard, T. | 登録日 | 2014-08-18 | 公開日 | 2015-05-13 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology. Acs Med.Chem.Lett., 6, 2015
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8S9H
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![BU of 8s9h by Molmil](/molmil-images/mine/8s9h) | Crystal structure of monkey TLR7 ectodomain with compound 14 | 分子名称: | (3S)-3-{[5-amino-1-({3-methoxy-5-[1-(oxan-4-yl)piperidin-4-yl]pyridin-2-yl}methyl)-1H-pyrazolo[4,3-d]pyrimidin-7-yl]amino}hexan-1-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Critton, D.A. | 登録日 | 2023-03-28 | 公開日 | 2024-02-07 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.437 Å) | 主引用文献 | Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology. Acs Med.Chem.Lett., 15, 2024
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5W5Q
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![BU of 5w5q by Molmil](/molmil-images/mine/5w5q) | MAP4K4 in complex with inhibitor compound 12 (N3-methyl-10-(3-methyl-3-(5-methyloxazol-2-yl)but-1-yn-1-yl)-6,7-dihydro-5H-5,7-methanobenzo[c]imidazo[1,2-a]azepine-2,3-dicarboxamide) | 分子名称: | (5s,7s)-N~3~-methyl-10-[3-methyl-3-(5-methyl-1,3-oxazol-2-yl)but-1-yn-1-yl]-6,7-dihydro-5H-5,7-methanoimidazo[2,1-a][2]benzazepine-2,3-dicarboxamide, Mitogen-activated protein kinase kinase kinase kinase 4 | 著者 | Harris, S.F, Wu, P. | 登録日 | 2017-06-15 | 公開日 | 2018-06-20 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Structure Based Design of Potent Selective Inhibitors of Protein Kinase D1 (PKD1). Acs Med.Chem.Lett., 10, 2019
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