7YIS

Crystal structure of N-terminal PH domain of ARAP3 protein in complex with inositol 1,3,4,5-tetrakisphosphate

Summary for 7YIS

Entry DOI	10.2210/pdb7yis/pdb
Descriptor	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3, (2R)-3-{[(S)-{[(2S,3R,5S,6S)-2,6-DIHYDROXY-3,4,5-TRIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-(1-HYDROXY BUTOXY)PROPYL BUTYRATE (2 entities in total)
Functional Keywords	arap3, ph domain, complex, inositol 1, 3, 4, 5-tetrakisphosphate, cytosolic protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	13773.29
Authors	Zhang, Y.J.,Liu, Y.R.,Wu, B. (deposition date: 2022-07-18, release date: 2023-05-03, Last modification date: 2023-11-29)
Primary citation	Zhang, Y.,Ge, L.,Xu, L.,Liu, Y.,Wang, J.,Liu, C.,Zhao, H.,Xing, L.,Wang, J.,Wu, B. Structural Insights Uncover the Specific Phosphoinositide Recognition by the PH1 Domain of Arap3. Int J Mol Sci, 24:-, 2023 Cited by PubMed: 36674645 DOI: 10.3390/ijms24021125 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation