6R8X

COAGULATION FACTOR XI CATALYTIC DOMAIN IN COMPLEX WITH FAB-PORTION OF MAA868

Summary for 6R8X

• Entry DOI: 10.2210/pdb6r8x/pdb
• Descriptor: Coagulation factor XI, anti-Factor-XI Fab fragment light chain MAA868, anti-Factor-XI Fab fragment heavy chain MAA868, ... (4 entities in total)
• Functional Keywords: coagulation fxi, zymogen, antibody, antagonist, blood clotting
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 74741.64

Authors

Schiering, N.,Koch, A. (deposition date: 2019-04-02, release date: 2019-04-10)

• Primary citation: Koch, A.W.,Schiering, N.,Melkko, S.,Ewert, S.,Salter, J.,Zhang, Y.,McCormack, P.,Yu, J.,Huang, X.,Chiu, Y.H.,Chen, Z.,Schleeger, S.,Horny, G.,DiPetrillo, K.,Muller, L.,Hein, A.,Villard, F.,Scharenberg, M.,Ramage, P.,Hassiepen, U.,Cote, S.,DeGagne, J.,Krantz, C.,Eder, J.,Stoll, B.,Kulmatycki, K.,Feldman, D.L.,Hoffmann, P.,Basson, C.T.,Frost, R.J.A.,Khder, Y.; MAA868, a novel FXI antibody with a unique binding mode, shows durable effects on markers of anticoagulation in humans.; Blood, 133:1507-1516, 2019; PubMed: 30692123; DOI: 10.1182/blood-2018-10-880849

Experimental method

X-RAY DIFFRACTION (2.04 Å)