6XOI
 
 | | Structure of SUMO1-ML00752641 adduct bound to SAE | | 分子名称: | SULFATE ION, SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ... | | 著者 | Sintchak, M, Lane, W, Bump, N. | | 登録日 | 2020-07-07 | | 公開日 | 2021-03-24 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer.
J.Med.Chem., 64, 2021
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8GVA
 | | The intermediate structure of hAE2 in basic pH | | 分子名称: | Anion exchange protein 2 | | 著者 | Zhang, Q, Jian, L, Yao, D, Rao, B, Hu, K, Xia, Y, Cao, Y. | | 登録日 | 2022-09-14 | | 公開日 | 2023-04-12 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | | 主引用文献 | The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2.
Nat Commun, 14, 2023
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8GVE
 | | The asymmetry structure of hAE2 | | 分子名称: | Anion exchange protein 2 | | 著者 | Zhang, Q, Jian, L, Yao, D, Rao, B, Hu, K, Xia, Y, Cao, Y. | | 登録日 | 2022-09-15 | | 公開日 | 2023-04-12 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | | 主引用文献 | The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2.
Nat Commun, 14, 2023
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8GV8
 | | The cryo-EM structure of hAE2 with DIDS | | 分子名称: | 2,2'-ethane-1,2-diylbis{5-[(sulfanylmethyl)amino]benzenesulfonic acid}, Anion exchange protein 2 | | 著者 | Zhang, Q, Jian, L, Yao, D, Rao, B, Hu, K, Xia, Y, Cao, Y. | | 登録日 | 2022-09-14 | | 公開日 | 2023-04-12 | | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | | 主引用文献 | The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2.
Nat Commun, 14, 2023
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5MXX
 | | Crystal structure of human SR protein kinase 1 (SRPK1) in complex with compound 1 | | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-methyl-~{N}-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamide, ... | | 著者 | Tallant, C, Redondo, C, Batson, J, Toop, H.D, Babaebi-Jadidib, R, Savitsky, P, Elkins, J.M, Newman, J.A, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bates, D.O, Morris, J.C, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2017-01-25 | | 公開日 | 2017-05-24 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease.
ACS Chem. Biol., 12, 2017
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5MY8
 | | Crystal structure of SRPK1 in complex with SPHINX31 | | 分子名称: | 1,2-ETHANEDIOL, CITRIC ACID, DIMETHYL SULFOXIDE, ... | | 著者 | Chaikuad, A, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2017-01-25 | | 公開日 | 2017-05-10 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease.
ACS Chem. Biol., 12, 2017
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5MYV
 | | Crystal structure of SRPK2 in complex with compound 1 | | 分子名称: | 5-methyl-~{N}-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamide, DIMETHYL SULFOXIDE, SRSF protein kinase 2,SRSF protein kinase 2, ... | | 著者 | Chaikuad, A, Pike, A.C.W, Savitsky, P, von Delft, F, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2017-01-29 | | 公開日 | 2017-05-10 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease.
ACS Chem. Biol., 12, 2017
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7XOE
 | | Cryo-EM structure of S glycoprotein encoded by the Covid-19 mRNA vaccine candidate RQ3013 (Prefusion state) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,peptide | | 著者 | Wu, Z, Yu, Z, Tan, S, Lu, J, Lu, G, Lin, J. | | 登録日 | 2022-05-01 | | 公開日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants.
Sci Bull (Beijing), 68, 2023
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7XOG
 | | Cryo-EM structure of S glycoprotein encoded by the Covid-19 mRNA vaccine candidate RQ3013 (Postfusion state) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,peptide, ... | | 著者 | Wu, Z, Yu, Z, Tan, S, Lu, J, Lu, G, Lin, J. | | 登録日 | 2022-05-01 | | 公開日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants.
Sci Bull (Beijing), 68, 2023
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8HAW
 | | An auto-activation mechanism of plant non-specific phospholipase C | | 分子名称: | CALCIUM ION, GLYCEROL, Non-specific phospholipase C4, ... | | 著者 | Zhao, F, Fan, R.Y, Guan, Z.Y, Guo, L, Yin, P. | | 登録日 | 2022-10-26 | | 公開日 | 2023-01-25 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Insights into the mechanism of phospholipid hydrolysis by plant non-specific phospholipase C.
Nat Commun, 14, 2023
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8HAV
 | | An auto-activation mechanism of plant non-specific phospholipase C | | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Non-specific phospholipase C4 | | 著者 | Zhao, F, Fan, R.Y, Guan, Z.Y, Guo, L, Yin, P. | | 登録日 | 2022-10-26 | | 公開日 | 2023-01-25 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Insights into the mechanism of phospholipid hydrolysis by plant non-specific phospholipase C.
Nat Commun, 14, 2023
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8GVH
 | | Human AE2 in acidic KNO3 | | 分子名称: | Anion exchange protein 2, CHOLESTEROL HEMISUCCINATE | | 著者 | Zhang, Q, Jian, L, Yao, D, Rao, B, Hu, K, Xia, Y, Cao, Y. | | 登録日 | 2022-09-15 | | 公開日 | 2023-04-12 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | | 主引用文献 | The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2.
Nat Commun, 14, 2023
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8GV9
 | | The cryo-EM structure of hAE2 with chloride ion | | 分子名称: | Anion exchange protein 2, CHLORIDE ION | | 著者 | Zhang, Q, Jian, L, Yao, D, Rao, B, Hu, K, Xia, Y, Cao, Y. | | 登録日 | 2022-09-14 | | 公開日 | 2023-04-12 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | | 主引用文献 | The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2.
Nat Commun, 14, 2023
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8GVC
 | | The cryo-EM structure of hAE2 with bicarbonate | | 分子名称: | Anion exchange protein 2, BICARBONATE ION | | 著者 | Zhang, Q, Jian, L, Yao, D, Rao, B, Hu, K, Xia, Y, Cao, Y. | | 登録日 | 2022-09-14 | | 公開日 | 2023-04-12 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | | 主引用文献 | The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2.
Nat Commun, 14, 2023
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8GVF
 | | The outward-facing structure of hAE2 in basic pH | | 分子名称: | Anion exchange protein 2 | | 著者 | Zhang, Q, Jian, L, Yao, D, Rao, B, Hu, K, Xia, Y, Cao, Y. | | 登録日 | 2022-09-15 | | 公開日 | 2023-04-12 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | | 主引用文献 | The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2.
Nat Commun, 14, 2023
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7CMZ
 | | Crystal Structure of BRCT7/8 in Complex with the APS Motif of PHF8 | | 分子名称: | DNA topoisomerase 2-binding protein 1, Histone lysine demethylase PHF8, POTASSIUM ION, ... | | 著者 | Che, S.Y, Ma, S, Cao, C, Yao, Z, Shi, L, Yang, N. | | 登録日 | 2020-07-29 | | 公開日 | 2021-03-17 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.695 Å) | | 主引用文献 | PHF8-promoted TOPBP1 demethylation drives ATR activation and preserves genome stability.
Sci Adv, 7, 2021
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6XSW
 | | Structure of the Notch3 NRR in complex with an antibody Fab Fragment | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-N3 Fab Heavy Chain, ... | | 著者 | Bard, J. | | 登録日 | 2020-07-16 | | 公開日 | 2021-07-21 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | | 主引用文献 | NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells.
Cell Rep Med, 2, 2021
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6L31
 | | L1 protein of human papillomavirus 6 | | 分子名称: | Major capsid protein L1 | | 著者 | Li, S.W, Liu, X.L, Gu, Y. | | 登録日 | 2019-10-07 | | 公開日 | 2019-12-25 | | 実験手法 | ELECTRON MICROSCOPY (4.18 Å) | | 主引用文献 | Neutralization sites of human papillomavirus-6 relate to virus attachment and entry phase in viral infection.
Emerg Microbes Infect, 8, 2019
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7EAN
 | | immune complex of SARS-CoV-2 RBD and cross-neutralizing antibody 6D6 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of SARS-CoV-2 cross-neutralizing mAb 6D6, Light chain of SARS-CoV-2 cross-neutralizing mAb 6D6, ... | | 著者 | Li, T.T, Gu, Y, Li, S.W. | | 登録日 | 2021-03-07 | | 公開日 | 2021-03-31 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants.
Nat Commun, 12, 2021
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6LRU
 | | Marsupenaeus japonicus ferritin mutant (T158H) | | 分子名称: | FE (III) ION, Ferritin, IMIDAZOLE, ... | | 著者 | Zhao, G, Tan, X, Zhang, T. | | 登録日 | 2020-01-16 | | 公開日 | 2020-11-25 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Converting histidine-induced 3D protein arrays in crystals into their 3D analogues in solution by metal coordination cross-linking.
Commun Chem, 2020
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6LRV
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7XP6
 | | Cryo-EM structure of a class T GPCR in active state | | 分子名称: | Endoglucanase H,Taste receptor type 2 member 46,Endoglucanase H,Taste receptor type 2 member 46,Bitter taste receptor T2R46, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Liu, Z.J, Hua, T, Xu, W.X, Wu, L.J. | | 登録日 | 2022-05-03 | | 公開日 | 2022-10-12 | | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | | 主引用文献 | Structural basis for strychnine activation of human bitter taste receptor TAS2R46.
Science, 377, 2022
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7XP4
 | | Cryo-EM structure of a class T GPCR in apo state | | 分子名称: | Endoglucanase H,Taste receptor type 2 member 46,Endoglucanase H,Taste receptor type 2 member 46,Bitter taste receptor T2R46, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Liu, Z.J, Hua, T, Xu, W.X, Wu, L.J. | | 登録日 | 2022-05-03 | | 公開日 | 2022-10-12 | | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | | 主引用文献 | Structural basis for strychnine activation of human bitter taste receptor TAS2R46.
Science, 377, 2022
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7XP5
 | | Cryo-EM structure of a class T GPCR in ligand-free state | | 分子名称: | Endoglucanase H,Taste receptor type 2 member 46,Bitter taste receptor T2R46, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Liu, Z.J, Hua, T, Xu, W.X, Wu, L.J. | | 登録日 | 2022-05-03 | | 公開日 | 2022-10-12 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | | 主引用文献 | Structural basis for strychnine activation of human bitter taste receptor TAS2R46.
Science, 377, 2022
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6LRX
 | | Marsupenaeus japonicus ferritin mutant(T158H) | | 分子名称: | FE (III) ION, Ferritin, NICKEL (II) ION | | 著者 | Zhao, G, Tan, X. | | 登録日 | 2020-01-16 | | 公開日 | 2020-11-25 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.702 Å) | | 主引用文献 | Converting histidine-induced 3D protein arrays in crystals into their 3D analogues in solution by metal coordination cross-linking.
Commun Chem, 2020
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