6XOI
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![BU of 6xoi by Molmil](/molmil-images/mine/6xoi) | Structure of SUMO1-ML00752641 adduct bound to SAE | 分子名称: | SULFATE ION, SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ... | 著者 | Sintchak, M, Lane, W, Bump, N. | 登録日 | 2020-07-07 | 公開日 | 2021-03-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer. J.Med.Chem., 64, 2021
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8GVA
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![BU of 8gva by Molmil](/molmil-images/mine/8gva) | The intermediate structure of hAE2 in basic pH | 分子名称: | Anion exchange protein 2 | 著者 | Zhang, Q, Jian, L, Yao, D, Rao, B, Hu, K, Xia, Y, Cao, Y. | 登録日 | 2022-09-14 | 公開日 | 2023-04-12 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2. Nat Commun, 14, 2023
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8GVE
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![BU of 8gve by Molmil](/molmil-images/mine/8gve) | The asymmetry structure of hAE2 | 分子名称: | Anion exchange protein 2 | 著者 | Zhang, Q, Jian, L, Yao, D, Rao, B, Hu, K, Xia, Y, Cao, Y. | 登録日 | 2022-09-15 | 公開日 | 2023-04-12 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | 主引用文献 | The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2. Nat Commun, 14, 2023
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8GV8
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![BU of 8gv8 by Molmil](/molmil-images/mine/8gv8) | The cryo-EM structure of hAE2 with DIDS | 分子名称: | 2,2'-ethane-1,2-diylbis{5-[(sulfanylmethyl)amino]benzenesulfonic acid}, Anion exchange protein 2 | 著者 | Zhang, Q, Jian, L, Yao, D, Rao, B, Hu, K, Xia, Y, Cao, Y. | 登録日 | 2022-09-14 | 公開日 | 2023-04-12 | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | 主引用文献 | The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2. Nat Commun, 14, 2023
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5MXX
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![BU of 5mxx by Molmil](/molmil-images/mine/5mxx) | Crystal structure of human SR protein kinase 1 (SRPK1) in complex with compound 1 | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-methyl-~{N}-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamide, ... | 著者 | Tallant, C, Redondo, C, Batson, J, Toop, H.D, Babaebi-Jadidib, R, Savitsky, P, Elkins, J.M, Newman, J.A, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bates, D.O, Morris, J.C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2017-01-25 | 公開日 | 2017-05-24 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease. ACS Chem. Biol., 12, 2017
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5MY8
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![BU of 5my8 by Molmil](/molmil-images/mine/5my8) | Crystal structure of SRPK1 in complex with SPHINX31 | 分子名称: | 1,2-ETHANEDIOL, CITRIC ACID, DIMETHYL SULFOXIDE, ... | 著者 | Chaikuad, A, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2017-01-25 | 公開日 | 2017-05-10 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease. ACS Chem. Biol., 12, 2017
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5MYV
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![BU of 5myv by Molmil](/molmil-images/mine/5myv) | Crystal structure of SRPK2 in complex with compound 1 | 分子名称: | 5-methyl-~{N}-[2-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]furan-2-carboxamide, DIMETHYL SULFOXIDE, SRSF protein kinase 2,SRSF protein kinase 2, ... | 著者 | Chaikuad, A, Pike, A.C.W, Savitsky, P, von Delft, F, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2017-01-29 | 公開日 | 2017-05-10 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease. ACS Chem. Biol., 12, 2017
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7XOE
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![BU of 7xoe by Molmil](/molmil-images/mine/7xoe) | Cryo-EM structure of S glycoprotein encoded by the Covid-19 mRNA vaccine candidate RQ3013 (Prefusion state) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,peptide | 著者 | Wu, Z, Yu, Z, Tan, S, Lu, J, Lu, G, Lin, J. | 登録日 | 2022-05-01 | 公開日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants. Sci Bull (Beijing), 68, 2023
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7XOG
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![BU of 7xog by Molmil](/molmil-images/mine/7xog) | Cryo-EM structure of S glycoprotein encoded by the Covid-19 mRNA vaccine candidate RQ3013 (Postfusion state) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,peptide, ... | 著者 | Wu, Z, Yu, Z, Tan, S, Lu, J, Lu, G, Lin, J. | 登録日 | 2022-05-01 | 公開日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants. Sci Bull (Beijing), 68, 2023
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8HAW
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![BU of 8haw by Molmil](/molmil-images/mine/8haw) | An auto-activation mechanism of plant non-specific phospholipase C | 分子名称: | CALCIUM ION, GLYCEROL, Non-specific phospholipase C4, ... | 著者 | Zhao, F, Fan, R.Y, Guan, Z.Y, Guo, L, Yin, P. | 登録日 | 2022-10-26 | 公開日 | 2023-01-25 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Insights into the mechanism of phospholipid hydrolysis by plant non-specific phospholipase C. Nat Commun, 14, 2023
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8HAV
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![BU of 8hav by Molmil](/molmil-images/mine/8hav) | An auto-activation mechanism of plant non-specific phospholipase C | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Non-specific phospholipase C4 | 著者 | Zhao, F, Fan, R.Y, Guan, Z.Y, Guo, L, Yin, P. | 登録日 | 2022-10-26 | 公開日 | 2023-01-25 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Insights into the mechanism of phospholipid hydrolysis by plant non-specific phospholipase C. Nat Commun, 14, 2023
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8GVH
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![BU of 8gvh by Molmil](/molmil-images/mine/8gvh) | Human AE2 in acidic KNO3 | 分子名称: | Anion exchange protein 2, CHOLESTEROL HEMISUCCINATE | 著者 | Zhang, Q, Jian, L, Yao, D, Rao, B, Hu, K, Xia, Y, Cao, Y. | 登録日 | 2022-09-15 | 公開日 | 2023-04-12 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2. Nat Commun, 14, 2023
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8GV9
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![BU of 8gv9 by Molmil](/molmil-images/mine/8gv9) | The cryo-EM structure of hAE2 with chloride ion | 分子名称: | Anion exchange protein 2, CHLORIDE ION | 著者 | Zhang, Q, Jian, L, Yao, D, Rao, B, Hu, K, Xia, Y, Cao, Y. | 登録日 | 2022-09-14 | 公開日 | 2023-04-12 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2. Nat Commun, 14, 2023
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8GVC
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![BU of 8gvc by Molmil](/molmil-images/mine/8gvc) | The cryo-EM structure of hAE2 with bicarbonate | 分子名称: | Anion exchange protein 2, BICARBONATE ION | 著者 | Zhang, Q, Jian, L, Yao, D, Rao, B, Hu, K, Xia, Y, Cao, Y. | 登録日 | 2022-09-14 | 公開日 | 2023-04-12 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2. Nat Commun, 14, 2023
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8GVF
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![BU of 8gvf by Molmil](/molmil-images/mine/8gvf) | The outward-facing structure of hAE2 in basic pH | 分子名称: | Anion exchange protein 2 | 著者 | Zhang, Q, Jian, L, Yao, D, Rao, B, Hu, K, Xia, Y, Cao, Y. | 登録日 | 2022-09-15 | 公開日 | 2023-04-12 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2. Nat Commun, 14, 2023
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7CMZ
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![BU of 7cmz by Molmil](/molmil-images/mine/7cmz) | Crystal Structure of BRCT7/8 in Complex with the APS Motif of PHF8 | 分子名称: | DNA topoisomerase 2-binding protein 1, Histone lysine demethylase PHF8, POTASSIUM ION, ... | 著者 | Che, S.Y, Ma, S, Cao, C, Yao, Z, Shi, L, Yang, N. | 登録日 | 2020-07-29 | 公開日 | 2021-03-17 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.695 Å) | 主引用文献 | PHF8-promoted TOPBP1 demethylation drives ATR activation and preserves genome stability. Sci Adv, 7, 2021
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6XSW
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![BU of 6xsw by Molmil](/molmil-images/mine/6xsw) | Structure of the Notch3 NRR in complex with an antibody Fab Fragment | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-N3 Fab Heavy Chain, ... | 著者 | Bard, J. | 登録日 | 2020-07-16 | 公開日 | 2021-07-21 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | 主引用文献 | NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells. Cell Rep Med, 2, 2021
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6L31
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![BU of 6l31 by Molmil](/molmil-images/mine/6l31) | L1 protein of human papillomavirus 6 | 分子名称: | Major capsid protein L1 | 著者 | Li, S.W, Liu, X.L, Gu, Y. | 登録日 | 2019-10-07 | 公開日 | 2019-12-25 | 実験手法 | ELECTRON MICROSCOPY (4.18 Å) | 主引用文献 | Neutralization sites of human papillomavirus-6 relate to virus attachment and entry phase in viral infection. Emerg Microbes Infect, 8, 2019
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7EAN
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![BU of 7ean by Molmil](/molmil-images/mine/7ean) | immune complex of SARS-CoV-2 RBD and cross-neutralizing antibody 6D6 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of SARS-CoV-2 cross-neutralizing mAb 6D6, Light chain of SARS-CoV-2 cross-neutralizing mAb 6D6, ... | 著者 | Li, T.T, Gu, Y, Li, S.W. | 登録日 | 2021-03-07 | 公開日 | 2021-03-31 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants. Nat Commun, 12, 2021
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6LRU
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![BU of 6lru by Molmil](/molmil-images/mine/6lru) | Marsupenaeus japonicus ferritin mutant (T158H) | 分子名称: | FE (III) ION, Ferritin, IMIDAZOLE, ... | 著者 | Zhao, G, Tan, X, Zhang, T. | 登録日 | 2020-01-16 | 公開日 | 2020-11-25 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Converting histidine-induced 3D protein arrays in crystals into their 3D analogues in solution by metal coordination cross-linking. Commun Chem, 2020
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6LRV
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![BU of 6lrv by Molmil](/molmil-images/mine/6lrv) | |
7XP6
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![BU of 7xp6 by Molmil](/molmil-images/mine/7xp6) | Cryo-EM structure of a class T GPCR in active state | 分子名称: | Endoglucanase H,Taste receptor type 2 member 46,Endoglucanase H,Taste receptor type 2 member 46,Bitter taste receptor T2R46, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Liu, Z.J, Hua, T, Xu, W.X, Wu, L.J. | 登録日 | 2022-05-03 | 公開日 | 2022-10-12 | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | 主引用文献 | Structural basis for strychnine activation of human bitter taste receptor TAS2R46. Science, 377, 2022
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7XP4
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![BU of 7xp4 by Molmil](/molmil-images/mine/7xp4) | Cryo-EM structure of a class T GPCR in apo state | 分子名称: | Endoglucanase H,Taste receptor type 2 member 46,Endoglucanase H,Taste receptor type 2 member 46,Bitter taste receptor T2R46, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Liu, Z.J, Hua, T, Xu, W.X, Wu, L.J. | 登録日 | 2022-05-03 | 公開日 | 2022-10-12 | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | 主引用文献 | Structural basis for strychnine activation of human bitter taste receptor TAS2R46. Science, 377, 2022
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7XP5
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![BU of 7xp5 by Molmil](/molmil-images/mine/7xp5) | Cryo-EM structure of a class T GPCR in ligand-free state | 分子名称: | Endoglucanase H,Taste receptor type 2 member 46,Bitter taste receptor T2R46, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Liu, Z.J, Hua, T, Xu, W.X, Wu, L.J. | 登録日 | 2022-05-03 | 公開日 | 2022-10-12 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | 主引用文献 | Structural basis for strychnine activation of human bitter taste receptor TAS2R46. Science, 377, 2022
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6LRX
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![BU of 6lrx by Molmil](/molmil-images/mine/6lrx) | Marsupenaeus japonicus ferritin mutant(T158H) | 分子名称: | FE (III) ION, Ferritin, NICKEL (II) ION | 著者 | Zhao, G, Tan, X. | 登録日 | 2020-01-16 | 公開日 | 2020-11-25 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.702 Å) | 主引用文献 | Converting histidine-induced 3D protein arrays in crystals into their 3D analogues in solution by metal coordination cross-linking. Commun Chem, 2020
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