8GV8

The cryo-EM structure of hAE2 with DIDS

Summary for 8GV8

• Entry DOI: 10.2210/pdb8gv8/pdb
• EMDB information: 34287
• Descriptor: Anion exchange protein 2, 2,2'-ethane-1,2-diylbis{5-[(sulfanylmethyl)amino]benzenesulfonic acid} (2 entities in total)
• Functional Keywords: chloride and bicarbonate transporter human-ae2, transport protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 275283.01

Authors

Zhang, Q.,Jian, L.,Yao, D.,Rao, B.,Hu, K.,Xia, Y.,Cao, Y. (deposition date: 2022-09-14, release date: 2023-04-12)

• Primary citation: Zhang, Q.,Jian, L.,Yao, D.,Rao, B.,Xia, Y.,Hu, K.,Li, S.,Shen, Y.,Cao, M.,Qin, A.,Zhao, J.,Cao, Y.; The structural basis of the pH-homeostasis mediated by the Cl - /HCO 3 - exchanger, AE2.; Nat Commun, 14:1812-1812, 2023; PubMed: 37002221; DOI: 10.1038/s41467-023-37557-y

Experimental method

ELECTRON MICROSCOPY (3.08 Å)