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8GV8

The cryo-EM structure of hAE2 with DIDS

Functional Information from GO Data
ChainGOidnamespacecontents
A0005452molecular_functionsolute:inorganic anion antiporter activity
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0006811biological_processmonoatomic ion transport
A0006820biological_processmonoatomic anion transport
A0007283biological_processspermatogenesis
A0008509molecular_functionmonoatomic anion transmembrane transporter activity
A0015075molecular_functionmonoatomic ion transmembrane transporter activity
A0015106molecular_functionbicarbonate transmembrane transporter activity
A0015297molecular_functionantiporter activity
A0015698biological_processinorganic anion transport
A0015701biological_processbicarbonate transport
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016324cellular_componentapical plasma membrane
A0019899molecular_functionenzyme binding
A0022857molecular_functiontransmembrane transporter activity
A0030316biological_processosteoclast differentiation
A0032956biological_processregulation of actin cytoskeleton organization
A0034220biological_processmonoatomic ion transmembrane transport
A0043377biological_processnegative regulation of CD8-positive, alpha-beta T cell differentiation
A0045124biological_processregulation of bone resorption
A0048565biological_processdigestive tract development
A0051453biological_processregulation of intracellular pH
A0055085biological_processtransmembrane transport
A0070175biological_processpositive regulation of enamel mineralization
A0097186biological_processamelogenesis
A0098656biological_processmonoatomic anion transmembrane transport
A0098660biological_processinorganic ion transmembrane transport
A0140900molecular_functionchloride:bicarbonate antiporter activity
A1902476biological_processchloride transmembrane transport
A2000565biological_processnegative regulation of CD8-positive, alpha-beta T cell proliferation
B0005452molecular_functionsolute:inorganic anion antiporter activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0006811biological_processmonoatomic ion transport
B0006820biological_processmonoatomic anion transport
B0007283biological_processspermatogenesis
B0008509molecular_functionmonoatomic anion transmembrane transporter activity
B0015075molecular_functionmonoatomic ion transmembrane transporter activity
B0015106molecular_functionbicarbonate transmembrane transporter activity
B0015297molecular_functionantiporter activity
B0015698biological_processinorganic anion transport
B0015701biological_processbicarbonate transport
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0016324cellular_componentapical plasma membrane
B0019899molecular_functionenzyme binding
B0022857molecular_functiontransmembrane transporter activity
B0030316biological_processosteoclast differentiation
B0032956biological_processregulation of actin cytoskeleton organization
B0034220biological_processmonoatomic ion transmembrane transport
B0043377biological_processnegative regulation of CD8-positive, alpha-beta T cell differentiation
B0045124biological_processregulation of bone resorption
B0048565biological_processdigestive tract development
B0051453biological_processregulation of intracellular pH
B0055085biological_processtransmembrane transport
B0070175biological_processpositive regulation of enamel mineralization
B0097186biological_processamelogenesis
B0098656biological_processmonoatomic anion transmembrane transport
B0098660biological_processinorganic ion transmembrane transport
B0140900molecular_functionchloride:bicarbonate antiporter activity
B1902476biological_processchloride transmembrane transport
B2000565biological_processnegative regulation of CD8-positive, alpha-beta T cell proliferation
Functional Information from PROSITE/UniProt
site_idPS00219
Number of Residues12
DetailsANION_EXCHANGER_1 Anion exchangers family signature 1. FGGLIRDVRRRY
ChainResidueDetails
APHE682-TYR693

site_idPS00220
Number of Residues15
DetailsANION_EXCHANGER_2 Anion exchangers family signature 2. FLISLIFIYETFyKL
ChainResidueDetails
APHE829-LEU843

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1440
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-GLN707
AARG919-ARG933
BMET1-GLN707
BARG919-ARG933

site_idSWS_FT_FI2
Number of Residues552
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
ACYS708-GLY731
AMET1163-LEU1199
BCYS708-GLY731
BLEU737-PHE774
BSER784-VAL816
BILE826-PHE847
BALA901-LEU918
BVAL934-ILE954
BPRO988-MET1010
BLEU1036-VAL1059
BVAL1091-TYR1136
ALEU737-PHE774
BMET1163-LEU1199
ASER784-VAL816
AILE826-PHE847
AALA901-LEU918
AVAL934-ILE954
APRO988-MET1010
ALEU1036-VAL1059
AVAL1091-TYR1136

site_idSWS_FT_FI3
Number of Residues104
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
AGLN848-THR900
BGLN848-THR900

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
ASER113
ASER132
BSER113
BSER132

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332
ChainResidueDetails
ASER144
BSER144

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P13808
ChainResidueDetails
ASER170
ASER172
BSER170
BSER172

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER173
BSER173

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648
ChainResidueDetails
ATHR183
BTHR183

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER243
BSER243

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P13808
ChainResidueDetails
ATHR257
BTHR257

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: N6-methyllysine => ECO:0007744|PubMed:24129315
ChainResidueDetails
ALYS274
BLYS274

site_idSWS_FT_FI12
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692
ChainResidueDetails
ASER443
BSER443

site_idSWS_FT_FI13
Number of Residues2
DetailsLIPID: S-palmitoyl cysteine => ECO:0000250
ChainResidueDetails
ACYS1173
BCYS1173

site_idSWS_FT_FI14
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN859
AASN868
AASN882
BASN859
BASN868
BASN882

226707

PDB entries from 2024-10-30

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