7CMZ

Crystal Structure of BRCT7/8 in Complex with the APS Motif of PHF8

Summary for 7CMZ

• Entry DOI: 10.2210/pdb7cmz/pdb
• Descriptor: DNA topoisomerase 2-binding protein 1, Histone lysine demethylase PHF8, POTASSIUM ION, ... (5 entities in total)
• Functional Keywords: topbp1, protein binding-hydrolase complex, protein binding/hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 28544.43

Authors

Che, S.Y.,Ma, S.,Cao, C.,Yao, Z.,Shi, L.,Yang, N. (deposition date: 2020-07-29, release date: 2021-03-17, Last modification date: 2023-11-29)

• Primary citation: Ma, S.,Cao, C.,Che, S.,Wang, Y.,Su, D.,Liu, S.,Gong, W.,Liu, L.,Sun, J.,Zhao, J.,Wang, Q.,Song, N.,Ge, T.,Guo, Q.,Tian, S.,Chen, C.D.,Zhang, T.,Wang, J.,Ding, X.,Yang, F.,Ying, G.,Yang, J.,Zhang, K.,Zhu, Y.,Yao, Z.,Yang, N.,Shi, L.; PHF8-promoted TOPBP1 demethylation drives ATR activation and preserves genome stability.; Sci Adv, 7:-, 2021; PubMed: 33952527; DOI: 10.1126/sciadv.abf7684

Experimental method

X-RAY DIFFRACTION (1.695 Å)