6XSW

Structure of the Notch3 NRR in complex with an antibody Fab Fragment

Summary for 6XSW

• Entry DOI: 10.2210/pdb6xsw/pdb
• Descriptor: Anti-N3 Fab Heavy Chain, Anti-N3 Fab Light Chain, Neurogenic locus notch homolog protein 3, ... (7 entities in total)
• Functional Keywords: notch3, antibody, signaling protein, signaling protein-immune system complex, signaling protein/immune system
• Biological source: Rattus norvegicus; More
• Total number of polymer chains: 12
• Total formula weight: 318978.95

Authors

Bard, J. (deposition date: 2020-07-16, release date: 2021-07-21, Last modification date: 2023-10-25)

• Primary citation: Geles, K.G.,Gao, Y.,Giannakou, A.,Sridharan, L.,Yamin, T.T.,Zhang, J.,Karim, R.,Bard, J.,Piche-Nicholas, N.,Charati, M.,Maderna, A.,Lucas, J.,Golas, J.,Guffroy, M.,Pirie-Shepherd, S.,Roy, M.,Qian, J.,Franks, T.,Zhong, W.,O'Donnell, C.J.,Tchistiakova, L.,Gerber, H.P.,Sapra, P.; NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells.; Cell Rep Med, 2:100279-100279, 2021; PubMed: 34095881; DOI: 10.1016/j.xcrm.2021.100279

Experimental method

X-RAY DIFFRACTION (2.98 Å)