6XSW
Structure of the Notch3 NRR in complex with an antibody Fab Fragment
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, G, H (A, D, G, H) | Anti-N3 Fab Heavy Chain | polymer | 231 | 24713.7 | 4 | Rattus norvegicus | ||
| 2 | B, E, I, K (B, E, I, L) | Anti-N3 Fab Light Chain | polymer | 214 | 23509.1 | 4 | Rattus norvegicus | ||
| 3 | C, F, J, L (C, F, J, X) | Neurogenic locus notch homolog protein 3 | polymer | 280 | 31175.0 | 4 | UniProt (Q9UM47) Pfam (PF00066) Pfam (PF06816) Pfam (PF07684) | Homo sapiens (Human) | Notch 3 |
| 4 | M (P) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | AA, BA, N, O, P... (X, C, F, J) | CALCIUM ION | non-polymer | 40.1 | 13 | Chemie (CA) | |||
| 6 | Q, U (C, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 7 | CA, DA, EA, FA, GA (A, G, H, J, L) | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
C, F, J, X: 1379 - 1635 (UniProt: Q9UM47)
| PDB | External Database | Details |
|---|---|---|
| Met 1342 | - | expression tag |
| Glu 1343 | - | expression tag |
| Thr 1344 | - | expression tag |
| Asp 1345 | - | expression tag |
| Thr 1346 | - | expression tag |
| Leu 1347 | - | expression tag |
| Leu 1348 | - | expression tag |
| Leu 1349 | - | expression tag |
| Trp 1350 | - | expression tag |
| Val 1351 | - | expression tag |
| Leu 1352 | - | expression tag |
| Leu 1353 | - | expression tag |
| Leu 1354 | - | expression tag |
| Trp 1355 | - | expression tag |
| Val 1356 | - | expression tag |
| Pro 1357 | - | expression tag |
| Gly 1358 | - | expression tag |
| Ser 1359 | - | expression tag |
| Thr 1360 | - | expression tag |
| Gly 1361 | - | expression tag |
| Gly 1362 | - | expression tag |
| Ser 1363 | - | expression tag |
| Gly 1364 | - | expression tag |
| His 1365 | - | expression tag |
| His 1366 | - | expression tag |
| His 1367 | - | expression tag |
| His 1368 | - | expression tag |
| His 1369 | - | expression tag |
| His 1370 | - | expression tag |
| Gly 1371 | - | expression tag |
| Glu 1372 | - | expression tag |
| Asn 1373 | - | expression tag |
| Leu 1374 | - | expression tag |
| Tyr 1375 | - | expression tag |
| Phe 1376 | - | expression tag |
| Gln 1377 | - | expression tag |
| Ser 1378 | - | expression tag |
| - | Pro 1561 | deletion |
| - | Ser 1562 | deletion |
| - | Pro 1563 | deletion |
| - | Gly 1564 | deletion |
| - | Ser 1565 | deletion |
| - | Glu 1566 | deletion |
| - | Pro 1567 | deletion |
| - | Arg 1568 | deletion |
| - | Ala 1569 | deletion |
| - | Arg 1570 | deletion |
| - | Arg 1571 | deletion |
| - | Glu 1572 | deletion |
| - | Leu 1573 | deletion |
| - | Ala 1574 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 317591.1 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 963.4 | |
| All* | Total formula weight | 318978.9 |
