7WZV
| The structure of a Twitch Radical SAM Dehydrogenase SpeY | 分子名称: | (1~{S},2~{R},4~{S},5~{R})-2,4-bis(methylamino)-6-[(2~{S},3~{R},4~{S},6~{R})-6-methyl-3,4-bis(oxidanyl)oxan-2-yl]oxy-cyclohexane-1,3,5-triol, 1,2-ETHANEDIOL, 4Fe-4S cluster-binding domain-containing protein, ... | 著者 | Zhou, J.H, Hou, X.L. | 登録日 | 2022-02-19 | 公開日 | 2022-12-28 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.899313 Å) | 主引用文献 | Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical S -Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase. J.Am.Chem.Soc., 144, 2022
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7X0B
| The structure of a Twitch Radical SAM Dehydrogenase SpeY | 分子名称: | 4Fe-4S cluster-binding domain-containing protein, CHLORIDE ION, GLYCEROL, ... | 著者 | Hou, X.L, Zhou, J.H. | 登録日 | 2022-02-21 | 公開日 | 2022-12-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.02027535 Å) | 主引用文献 | Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical S -Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase. J.Am.Chem.Soc., 144, 2022
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4RYY
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4RYZ
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7DEY
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4NSR
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4NSO
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2LL4
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2LL3
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1RDR
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8XAV
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3H2L
| Crystal structure of HCV NS5B polymerase in complex with a novel bicyclic dihydro-pyridinone inhibitor | 分子名称: | N-{3-[(4aR,7aS)-1-(4-fluorobenzyl)-4-hydroxy-2-oxo-2,4a,5,6,7,7a-hexahydro-1H-cyclopenta[b]pyridin-3-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide, NS5B polymerase | 著者 | Han, Q, Showalter, R.E, Zhou, Q, Kissinger, C.R. | 登録日 | 2009-04-14 | 公開日 | 2009-12-08 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase. Bioorg.Med.Chem.Lett., 19, 2009
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7XOZ
| Crystal structure of RPPT-TIR | 分子名称: | ADENOSINE-5-DIPHOSPHORIBOSE, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase | 著者 | Song, W, Jia, A, Huang, S, Chai, J. | 登録日 | 2022-05-02 | 公開日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity. Science, 377, 2022
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4NWL
| Crystal structure of hepatis c virus protease (ns3) complexed with bms-650032 aka n-(tert-butoxycarbonyl)-3-me thyl-l-valyl-(4r)-4-((7-chloro-4-methoxy-1-isoquinolinyl)o xy)-n-((1r,2s)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylc yclopropyl)-l-prolinamide | 分子名称: | HCV NS3 1a Protease, N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-[(7-chloro-4-methoxyisoquinolin-1-yl)oxy]-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}-L-prolinamide, ZINC ION | 著者 | Muckelbauer, J.K, Klei, H.E. | 登録日 | 2013-12-06 | 公開日 | 2014-03-26 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection. J.Med.Chem., 57, 2014
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4W6E
| Human Tankyrase 1 with small molecule inhibitor | 分子名称: | 2-(4-{6-[(3S)-3,4-dimethylpiperazin-1-yl]-4-methylpyridin-3-yl}phenyl)-8-(hydroxymethyl)quinazolin-4(3H)-one, Tankyrase-1, ZINC ION | 著者 | Kazmirski, S.L, Johannes, J, Boriack-Sjodin, P.A, Howard, T. | 登録日 | 2014-08-20 | 公開日 | 2015-05-13 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology. Acs Med.Chem.Lett., 6, 2015
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6L56
| Fe(II) loaded Tegillarca granosa ferritin | 分子名称: | FE (II) ION, FE (III) ION, Ferritin, ... | 著者 | Jiang, Q.Q, Su, X.R, Ming, T.H, Huan, H.S. | 登録日 | 2019-10-22 | 公開日 | 2019-11-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.85300577 Å) | 主引用文献 | Structural Insights Into the Effects of Interactions With Iron and Copper Ions on Ferritin From the Blood Clam Tegillarca granosa. Front Mol Biosci, 9, 2022
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6LHC
| The cryo-EM structure of coxsackievirus A16 empty particle | 分子名称: | VP1, VP2, VP3 | 著者 | He, M.Z, Xu, L.F, Zheng, Q.B, Zhu, R, Yin, Z.C, Cheng, T, Li, S.W. | 登録日 | 2019-12-07 | 公開日 | 2020-02-05 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.43 Å) | 主引用文献 | Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16. Cell Host Microbe, 27, 2020
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6LHL
| The cryo-EM structure of coxsackievirus A16 A-particle in complex with Fab 18A7 | 分子名称: | VP1 protein, VP2 protein, VP3 protein | 著者 | He, M.Z, Xu, L.F, Zheng, Q.B, Zhu, R, Yin, Z.C, Cheng, T, Li, S.W. | 登録日 | 2019-12-09 | 公開日 | 2020-02-05 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16. Cell Host Microbe, 27, 2020
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6LHB
| The cryo-EM structure of coxsackievirus A16 A-particle | 分子名称: | VP1, VP2, VP3 | 著者 | He, M.Z, Xu, L.F, Zheng, Q.B, Zhu, R, Yin, Z.C, Cheng, T, Li, S.W. | 登録日 | 2019-12-07 | 公開日 | 2020-02-05 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.33 Å) | 主引用文献 | Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16. Cell Host Microbe, 27, 2020
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7XZ0
| TRIM E3 ubiquitin ligase | 分子名称: | Tripartite motif-containing protein 72, ZINC ION | 著者 | Park, S.H, Song, H.K. | 登録日 | 2022-06-02 | 公開日 | 2023-07-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.28 Å) | 主引用文献 | Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane. Nat.Struct.Mol.Biol., 30, 2023
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7XV2
| TRIM E3 ubiquitin ligase | 分子名称: | Tripartite motif-containing protein 72, ZINC ION | 著者 | Park, S.H, Song, H.K. | 登録日 | 2022-05-20 | 公開日 | 2023-05-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane. Nat.Struct.Mol.Biol., 30, 2023
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5VZ3
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8Z9A
| Cryo-EM structure of the insect olfactory receptor OR5-Orco heterocomplex from Acyrthosiphon pisum bound with geranyl acetate | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Odorant receptor, ApisOR5, ... | 著者 | Wang, Y.D, Qiu, L, Guan, Z.Y, Wang, Q, Wang, G.R, Yin, P. | 登録日 | 2024-04-23 | 公開日 | 2024-06-19 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for odorant recognition of the insect odorant receptor OR-Orco heterocomplex. Science, 384, 2024
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8Z9Z
| Cryo-EM structure of the insect olfactory receptor OR5-Orco heterocomplex from Acyrthosiphon pisum | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Odorant receptor, ApisOR5, ... | 著者 | Wang, Y.D, Qiu, L, Guan, Z.Y, Wang, Q, Wang, G.R, Yin, P. | 登録日 | 2024-04-24 | 公開日 | 2024-06-19 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural basis for odorant recognition of the insect odorant receptor OR-Orco heterocomplex. Science, 384, 2024
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7ML9
| The Mpp75Aa1.1 beta-pore-forming protein from Brevibacillus laterosporus | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Insecticidal protein, ... | 著者 | Rydel, T.J, Zheng, M, Evdokimov, A. | 登録日 | 2021-04-27 | 公開日 | 2021-05-05 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Structural and functional characterization of Mpp75Aa1.1, a putative beta-pore forming protein from Brevibacillus laterosporus active against the western corn rootworm. Plos One, 16, 2021
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