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3Q9H
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BU of 3q9h by Molmil
LVFFA segment from Alzheimer's Amyloid-Beta displayed on 42-membered macrocycle scaffold
分子名称: 1,4-BUTANEDIOL, Cyclic pseudo-peptide LVFFA(ORN)(HAO)LK(ORN), GLYCEROL, ...
著者Liu, C, Sawaya, M.R, Eisenberg, D, Nowick, J.S, Cheng, P, Zheng, J.
登録日2011-01-07
公開日2011-06-08
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Characteristics of Amyloid-Related Oligomers Revealed by Crystal Structures of Macrocyclic beta-Sheet Mimics.
J.Am.Chem.Soc., 133, 2011
6ISL
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BU of 6isl by Molmil
SnoaL-like cyclase XimE with its product xiamenmycin B
分子名称: (2R,3S)-2-methyl-2-(4-methylpent-3-enyl)-3-oxidanyl-3,4-dihydrochromene-6-carboxylic acid, XimE, SnoaL-like domain protein
著者He, B, Zhou, T, Bu, X, Weng, J, Xu, J, Lin, S, Zheng, J, Zhao, Y, Xu, M.
登録日2018-11-16
公開日2019-11-20
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Enzymatic Pyran Formation Involved in Xiamenmycin Biosynthesis
Acs Catalysis, 9, 2019
6ISK
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BU of 6isk by Molmil
SnoaL-like cyclase XimE
分子名称: 1,2-ETHANEDIOL, MALONIC ACID, XimE, ...
著者He, B, Zhou, T, Bu, X, Weng, J, Xu, J, Lin, S, Zheng, J, Zhao, Y, Xu, M.
登録日2018-11-16
公開日2019-11-20
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Enzymatic Pyran Formation Involved in Xiamenmycin Biosynthesis
Acs Catalysis, 9, 2019
6KJ7
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BU of 6kj7 by Molmil
E. coli ATCase catalytic subunit mutant - G166P
分子名称: Aspartate carbamoyltransferase catalytic subunit
著者Lei, Z, Zheng, J, Jia, Z.
登録日2019-07-21
公開日2020-03-18
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.839 Å)
主引用文献New regulatory mechanism-based inhibitors of aspartate transcarbamoylase for potential anticancer drug development.
Febs J., 287, 2020
6KJ9
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BU of 6kj9 by Molmil
E. coli ATCase catalytic subunit mutant - G128/130A
分子名称: Aspartate carbamoyltransferase catalytic subunit
著者Lei, Z, Zheng, J, Jia, Z.C.
登録日2019-07-22
公開日2020-03-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献New regulatory mechanism-based inhibitors of aspartate transcarbamoylase for potential anticancer drug development.
Febs J., 287, 2020
6KJ8
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BU of 6kj8 by Molmil
E. coli ATCase holoenzyme mutant - G166P (catalytic chain)
分子名称: Aspartate carbamoyltransferase catalytic subunit, Aspartate carbamoyltransferase regulatory chain, ZINC ION
著者Lei, Z, Zheng, J, Jia, Z.C.
登録日2019-07-22
公開日2020-03-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.011 Å)
主引用文献New regulatory mechanism-based inhibitors of aspartate transcarbamoylase for potential anticancer drug development.
Febs J., 287, 2020
6KJA
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BU of 6kja by Molmil
E. coli ATCase holoenzyme mutant - G128/130A (catalytic chain)
分子名称: Aspartate carbamoyltransferase catalytic subunit, Aspartate carbamoyltransferase regulatory chain, ZINC ION
著者Lei, Z, Zheng, J, Jia, Z.C.
登録日2019-07-22
公開日2020-03-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.064 Å)
主引用文献New regulatory mechanism-based inhibitors of aspartate transcarbamoylase for potential anticancer drug development.
Febs J., 287, 2020
8H8C
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BU of 8h8c by Molmil
Type VI secretion system effector RhsP in its post-autoproteolysis and dimeric form
分子名称: C-terminal peptide from Putative Rhs-family protein, Putative Rhs-family protein
著者Tang, L, Dong, S.Q, Rasheed, N, Wu, H.W, Zhou, N.K, Li, H.D, Wang, M.L, Zheng, J, He, J, Chao, W.C.H.
登録日2022-10-22
公開日2023-01-18
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.36 Å)
主引用文献Vibrio parahaemolyticus prey targeting requires autoproteolysis-triggered dimerization of the type VI secretion system effector RhsP.
Cell Rep, 41, 2022
8H8B
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BU of 8h8b by Molmil
Type VI secretion system effector RhsP in its pre-autoproteolysis and monomeric form
分子名称: Putative Rhs-family protein
著者Tang, L, Dong, S.Q, Rasheed, N, Wu, H.W, Zhou, N.K, Li, H.D, Wang, M.L, Zheng, J, He, J, Chao, W.C.H.
登録日2022-10-22
公開日2023-01-18
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.16 Å)
主引用文献Vibrio parahaemolyticus prey targeting requires autoproteolysis-triggered dimerization of the type VI secretion system effector RhsP.
Cell Rep, 41, 2022
8H8A
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BU of 8h8a by Molmil
Type VI secretion system effector RhsP in its post-autoproteolysis and monomeric form
分子名称: C-terminal peptide from Putative Rhs-family protein, Putative Rhs-family protein
著者Tang, L, Dong, S.Q, Rasheed, N, Wu, H.W, Zhou, N.K, Li, H.D, Wang, M.L, Zheng, J, He, J, Chao, W.C.H.
登録日2022-10-22
公開日2023-01-18
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.25 Å)
主引用文献Vibrio parahaemolyticus prey targeting requires autoproteolysis-triggered dimerization of the type VI secretion system effector RhsP.
Cell Rep, 41, 2022
8YL5
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BU of 8yl5 by Molmil
The DSR2-DSAD1 complex with DSAD1 on the same sides
分子名称: DSAD1, SIR2-like domain-containing protein
著者Yang, X, Zheng, J.
登録日2024-03-05
公開日2024-08-14
実験手法ELECTRON MICROSCOPY (3.45 Å)
主引用文献Structural insights into autoinhibition and activation of defense-associated sirtuin protein.
Int.J.Biol.Macromol., 277, 2024
5AYW
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BU of 5ayw by Molmil
Structure of a membrane complex
分子名称: Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ...
著者Huang, Y, Han, L, Zheng, J.
登録日2015-09-14
公開日2016-02-24
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (3.555 Å)
主引用文献Structure of the BAM complex and its implications for biogenesis of outer-membrane proteins
Nat.Struct.Mol.Biol., 23, 2016
6IIH
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BU of 6iih by Molmil
crystal structure of mitochondrial calcium uptake 2(MICU2)
分子名称: CALCIUM ION, Endolysin,Calcium uptake protein 2, mitochondrial
著者Shen, Q, Wu, W, Zheng, J, Jia, Z.
登録日2018-10-06
公開日2019-08-14
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.958 Å)
主引用文献The crystal structure of MICU2 provides insight into Ca2+binding and MICU1-MICU2 heterodimer formation.
Embo Rep., 20, 2019
6IYO
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BU of 6iyo by Molmil
Crystal Structure of the acyltransferase domain from the second module of the salinomycin polyketide synthase
分子名称: Type I modular polyketide synthase
著者Zhang, F, Zheng, J.
登録日2018-12-17
公開日2019-07-10
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Insights into the Substrate Specificity of Acyltransferases from Salinomycin Polyketide Synthase.
Biochemistry, 58, 2019
6J0U
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BU of 6j0u by Molmil
Crystal Structure of the acyltransferase domain from the third module of the ansamitocin polyketide synthase
分子名称: PHOSPHATE ION, Type 1 modular polyketide synthase
著者Zhang, F, Zheng, J.
登録日2018-12-26
公開日2019-12-18
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Structural and Biochemical Insight into the Recruitment of Acyl Carrier Protein-Linked Extender Units in Ansamitocin Biosynthesis.
Chembiochem, 21, 2020
6IYT
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BU of 6iyt by Molmil
Crystal Structure of the acyltransferase domain from second module 14 of salinomycin polyketide synthase
分子名称: Type I modular polyketide synthase
著者Zhang, F, Zheng, J.
登録日2018-12-17
公開日2019-07-03
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Structural Insights into the Substrate Specificity of Acyltransferases from Salinomycin Polyketide Synthase.
Biochemistry, 58, 2019
6K5L
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BU of 6k5l by Molmil
The crystal structure of isocitrate dehydrogenase kinase/phosphatase wtih two Mn2+ from E. coli
分子名称: ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, Isocitrate dehydrogenase kinase/phosphatase, ...
著者Zhang, X, Lei, Z, Zheng, J, Jia, Z.
登録日2019-05-29
公開日2019-07-03
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Characterization of metal binding of bifunctional kinase/phosphatase AceK and implication in activity modulation.
Sci Rep, 9, 2019
6IYR
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BU of 6iyr by Molmil
Crystal Structure of the acyltransferase domain from module 8 of the salinomycin polyketide synthase
分子名称: PHOSPHATE ION, Type I modular polyketide synthase
著者Zhang, F, Zheng, J.
登録日2018-12-17
公開日2019-07-03
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structural Insights into the Substrate Specificity of Acyltransferases from Salinomycin Polyketide Synthase.
Biochemistry, 58, 2019
6KJB
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BU of 6kjb by Molmil
wild-type apo-form E. coli ATCase holoenzyme with an unusual open conformation of R167
分子名称: Aspartate carbamoyltransferase catalytic subunit, Aspartate carbamoyltransferase regulatory chain, ZINC ION
著者Wang, N, Lei, Z, Zheng, J, Jia, Z.C.
登録日2019-07-22
公開日2020-06-03
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Conformational Plasticity of the Active Site Entrance inE. coliAspartate Transcarbamoylase and Its Implication in Feedback Regulation.
Int J Mol Sci, 21, 2020
8IA9
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BU of 8ia9 by Molmil
SpnK Methyltransferase from the Spinosyn Biosynthetic Pathway in Complex with Mg
分子名称: Demethylmacrocin O-methyltransferase, MAGNESIUM ION
著者Huang, S, Zheng, J.
登録日2023-02-08
公開日2023-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural and computational insights into the regioselectivity of SpnK involved in rhamnose methylation of spinosyn.
Int.J.Biol.Macromol., 253, 2023
8IAA
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BU of 8iaa by Molmil
SpnK Methyltransferase from the Spinosyn Biosynthetic Pathway in Complex with SAH
分子名称: Demethylmacrocin O-methyltransferase, MAGNESIUM ION, S-ADENOSYL-L-HOMOCYSTEINE
著者Huang, S, Zheng, J.
登録日2023-02-08
公開日2023-09-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural and computational insights into the regioselectivity of SpnK involved in rhamnose methylation of spinosyn.
Int.J.Biol.Macromol., 253, 2023
8HVR
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BU of 8hvr by Molmil
Cryo-EM structure of AfsR-dependent transcription activation complex with afsS promoter
分子名称: DNA (65-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Wang, Y, Zheng, J.
登録日2022-12-27
公開日2023-12-27
最終更新日2024-04-03
実験手法ELECTRON MICROSCOPY (3.35 Å)
主引用文献Structural and functional characterization of AfsR, an SARP family transcriptional activator of antibiotic biosynthesis in Streptomyces.
Plos Biol., 22, 2024
7VX0
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BU of 7vx0 by Molmil
The structure of GdmN complex with ATP
分子名称: 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, FE (III) ION, ...
著者Wei, J, Zheng, J, Zhou, J, Kang, Q, Bai, L.
登録日2021-11-12
公開日2022-11-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Endowing homodimeric carbamoyltransferase GdmN with iterative functions through structural characterization and mechanistic studies.
Nat Commun, 13, 2022
7VZN
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BU of 7vzn by Molmil
The structure of GdmN in complex with carbamoyl adenylate intermediate and 20-O-methyl-19-chloroproansamitocin
分子名称: (5~{S},6~{E},8~{S},9~{S},12~{R},15~{E})-21-chloranyl-12,20-dimethoxy-6,8,16-trimethyl-5,9-bis(oxidanyl)-2-azabicyclo[16.3.1]docosa-1(21),6,15,18(22),19-pentaene-3,11-dione, 1,2-ETHANEDIOL, 5'-O-[(S)-(carbamoyloxy)(hydroxy)phosphoryl]adenosine, ...
著者Wei, J, Zheng, J, Zhou, J, Kang, Q, Bai, L.
登録日2021-11-16
公開日2022-11-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Endowing homodimeric carbamoyltransferase GdmN with iterative functions through structural characterization and mechanistic studies.
Nat Commun, 13, 2022
7VZQ
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BU of 7vzq by Molmil
The structure of GdmN V24Y/G157A/R158A/G188R mutant in complex with carbamoyl adenylate intermediate
分子名称: 1,2-ETHANEDIOL, 5'-O-[(S)-(carbamoyloxy)(hydroxy)phosphoryl]adenosine, CHLORIDE ION, ...
著者Wei, J, Zheng, J, Zhou, J, Kang, Q, Bai, L.
登録日2021-11-16
公開日2022-11-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Endowing homodimeric carbamoyltransferase GdmN with iterative functions through structural characterization and mechanistic studies.
Nat Commun, 13, 2022

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