6KJ8

E. coli ATCase holoenzyme mutant - G166P (catalytic chain)

Summary for 6KJ8

Entry DOI	10.2210/pdb6kj8/pdb
Descriptor	Aspartate carbamoyltransferase catalytic subunit, Aspartate carbamoyltransferase regulatory chain, ZINC ION, ... (4 entities in total)
Functional Keywords	aspartate transcarbamoylase holoenzyme, de novo pyrimidine biosynthesis, transferase
Biological source	Escherichia coli K-12 More
Total number of polymer chains	6
Total formula weight	154758.62
Authors	Lei, Z.,Zheng, J.,Jia, Z.C. (deposition date: 2019-07-22, release date: 2020-03-11, Last modification date: 2023-11-22)
Primary citation	Lei, Z.,Wang, B.,Lu, Z.,Wang, N.,Tan, H.,Zheng, J.,Jia, Z. New regulatory mechanism-based inhibitors of aspartate transcarbamoylase for potential anticancer drug development. Febs J., 287:3579-3599, 2020 Cited by PubMed: 31967710 DOI: 10.1111/febs.15220 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.011 Å)

Structure validation