5K5M
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![BU of 5k5m by Molmil](/molmil-images/mine/5k5m) | |
3UIT
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![BU of 3uit by Molmil](/molmil-images/mine/3uit) | Overall structure of Patj/Pals1/Mals complex | 分子名称: | ACETATE ION, InaD-like protein, MAGUK p55 subfamily member 5, ... | 著者 | Zhang, J, Yang, X, Long, J, Shen, Y. | 登録日 | 2011-11-06 | 公開日 | 2012-02-22 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structure of an L27 domain heterotrimer from cell polarity complex Patj/Pals1/Mals2 reveals mutually independent L27 domain assembly mode J.Biol.Chem., 287, 2012
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7PZP
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![BU of 7pzp by Molmil](/molmil-images/mine/7pzp) | |
7PZR
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![BU of 7pzr by Molmil](/molmil-images/mine/7pzr) | |
6M0K
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![BU of 6m0k by Molmil](/molmil-images/mine/6m0k) | The crystal structure of COVID-19 main protease in complex with an inhibitor 11b | 分子名称: | 3C-like proteinase, DIMETHYL SULFOXIDE, ~{N}-[(2~{S})-3-(3-fluorophenyl)-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]-1~{H}-indole-2-carboxamide | 著者 | Zhang, B, Zhao, Y, Jin, Z, Liu, X, Yang, H, Liu, H, Rao, Z, Jiang, H. | 登録日 | 2020-02-22 | 公開日 | 2020-04-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.504 Å) | 主引用文献 | Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease. Science, 368, 2020
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8WD8
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![BU of 8wd8 by Molmil](/molmil-images/mine/8wd8) | Cryo-EM structure of TtdAgo-guide DNA-target DNA complex | 分子名称: | Argonaute family protein, Guide DNA, MAGNESIUM ION, ... | 著者 | Zhuang, L. | 登録日 | 2023-09-14 | 公開日 | 2024-01-31 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Molecular mechanism for target recognition, dimerization, and activation of Pyrococcus furiosus Argonaute. Mol.Cell, 84, 2024
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8X17
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![BU of 8x17 by Molmil](/molmil-images/mine/8x17) | Cryo-EM structure of adenosine receptor A3AR bound to CF102 | 分子名称: | Adenosine receptor A3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Cai, H, Xu, Y, Xu, H.E. | 登録日 | 2023-11-06 | 公開日 | 2024-04-24 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | 主引用文献 | Cryo-EM structures of adenosine receptor A 3 AR bound to selective agonists. Nat Commun, 15, 2024
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8X16
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![BU of 8x16 by Molmil](/molmil-images/mine/8x16) | Cryo-EM structure of adenosine receptor A3AR bound to CF101 | 分子名称: | Adenosine receptor A3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Cai, H, Xu, Y, Xu, H.E. | 登録日 | 2023-11-06 | 公開日 | 2024-04-24 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | 主引用文献 | Cryo-EM structures of adenosine receptor A 3 AR bound to selective agonists. Nat Commun, 15, 2024
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8GPY
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![BU of 8gpy by Molmil](/molmil-images/mine/8gpy) | Crystal structure of Omicron BA.4/5 RBD in complex with a neutralizing antibody scFv | 分子名称: | Spike protein S1, scFv | 著者 | Gao, Y.X, Song, Z.D, Wang, W.M, Guo, Y. | 登録日 | 2022-08-27 | 公開日 | 2023-06-28 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection. Nat Commun, 14, 2023
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8GOU
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![BU of 8gou by Molmil](/molmil-images/mine/8gou) | Omicron BA.4/5 SARS-CoV-2 S in complex with TH003 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, TH003 Fab heavy chain, ... | 著者 | Guo, Y, Zhang, G, Liang, J, Liu, F, Rao, Z. | 登録日 | 2022-08-25 | 公開日 | 2023-06-28 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection. Nat Commun, 14, 2023
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1VZT
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![BU of 1vzt by Molmil](/molmil-images/mine/1vzt) | ROLES OF INDIVIDUAL RESIDUES OF ALPHA-1,3 GALACTOSYLTRANSFERASES IN SUBSTRATE BINDING AND CATALYSIS | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MANGANESE (II) ION, N-ACETYLLACTOSAMINIDE ALPHA-1,3-GALACTOSYLTRANSFERASE, ... | 著者 | Zhang, Y, Swaminathan, G.J, Deshpande, A, Natesh, R, Xie, X, Acharya, K.R, Brew, K. | 登録日 | 2004-05-26 | 公開日 | 2005-05-26 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Roles of Individual Enzyme-Substrate Interactions by Alpha-1,3-Galactosyltransferase in Catalysis and Specificity. Biochemistry, 42, 2003
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6LI1
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![BU of 6li1 by Molmil](/molmil-images/mine/6li1) | Crystal structure of GPR52 ligand free form with flavodoxin fusion | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Chimera of G-protein coupled receptor 52 and Flavodoxin, DI(HYDROXYETHYL)ETHER, ... | 著者 | Luo, Z.P, Lin, X, Xu, F, Han, G.W. | 登録日 | 2019-12-10 | 公開日 | 2020-02-26 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural basis of ligand recognition and self-activation of orphan GPR52. Nature, 579, 2020
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6LI0
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![BU of 6li0 by Molmil](/molmil-images/mine/6li0) | Crystal structure of GPR52 in complex with agonist c17 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CITRATE ANION, Chimera of G-protein coupled receptor 52 and Flavodoxin, ... | 著者 | Luo, Z.P, Lin, X, Xu, F, Han, G.W. | 登録日 | 2019-12-10 | 公開日 | 2020-02-26 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural basis of ligand recognition and self-activation of orphan GPR52. Nature, 579, 2020
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6LI2
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![BU of 6li2 by Molmil](/molmil-images/mine/6li2) | Crystal structure of GPR52 ligand free form with rubredoxin fusion | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Chimera of G-protein coupled receptor 52 and Rubredoxin, DI(HYDROXYETHYL)ETHER, ... | 著者 | Luo, Z.P, Lin, X, Xu, F, Han, G.W. | 登録日 | 2019-12-10 | 公開日 | 2020-02-26 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis of ligand recognition and self-activation of orphan GPR52. Nature, 579, 2020
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6LI3
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![BU of 6li3 by Molmil](/molmil-images/mine/6li3) | cryo-EM structure of GPR52-miniGs-NB35 | 分子名称: | G-protein coupled receptor 52, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Li, M, Wang, N, Xu, F, Wu, J, Lei, M. | 登録日 | 2019-12-10 | 公開日 | 2020-02-26 | 最終更新日 | 2020-03-18 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Structural basis of ligand recognition and self-activation of orphan GPR52. Nature, 579, 2020
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1WDC
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![BU of 1wdc by Molmil](/molmil-images/mine/1wdc) | SCALLOP MYOSIN REGULATORY DOMAIN | 分子名称: | CALCIUM ION, MAGNESIUM ION, SCALLOP MYOSIN | 著者 | Houdusse, A, Cohen, C. | 登録日 | 1996-01-19 | 公開日 | 1996-07-11 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of the regulatory domain of scallop myosin at 2 A resolution: implications for regulation. Structure, 4, 1996
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3HLC
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![BU of 3hlc by Molmil](/molmil-images/mine/3hlc) | Simvastatin Synthase (LovD) from Aspergillus terreus, S5 mutant, unliganded | 分子名称: | GLYCEROL, TETRAETHYLENE GLYCOL, Transesterase | 著者 | Sawaya, M.R, Yeates, T.O, Laidman, J, Pashkov, I, Gao, X, Tang, Y. | 登録日 | 2009-05-27 | 公開日 | 2009-10-27 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Directed evolution and structural characterization of a simvastatin synthase Chem.Biol., 16, 2009
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3HLD
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![BU of 3hld by Molmil](/molmil-images/mine/3hld) | Simvastatin Synthase (LovD), from Aspergillus terreus, S5 mutant complex with monacolin J acid | 分子名称: | (3R,5R)-3,5-dihydroxy-7-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid, FORMIC ACID, Transesterase | 著者 | Sawaya, M.R, Yeates, T.O, Pashkov, I, Gao, X, Tang, Y. | 登録日 | 2009-05-27 | 公開日 | 2009-10-27 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Directed evolution and structural characterization of a simvastatin synthase Chem.Biol., 16, 2009
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3HLG
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![BU of 3hlg by Molmil](/molmil-images/mine/3hlg) | Simvastatin Synthase (LovD), from Aspergillus terreus, S5 mutant, S76A mutant, complex with lovastatin | 分子名称: | (3R,5R)-7-((1R,2R,6S,8R,8AS)-2,6-DIMETHYL-8-{[(2R)-2-METHYLBUTANOYL]OXY}-1,2,6,7,8,8A-HEXAHYDRONAPHTHALEN-1-YL)-3,5-DIHYDROXYHEPTANOIC ACID, Transesterase | 著者 | Sawaya, M.R, Yeates, T.O, Pashkov, I, Gao, X, Tang, Y. | 登録日 | 2009-05-27 | 公開日 | 2009-10-27 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Directed evolution and structural characterization of a simvastatin synthase Chem.Biol., 16, 2009
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3HLE
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![BU of 3hle by Molmil](/molmil-images/mine/3hle) | Simvastatin Synthase (LovD), from Aspergillus terreus, S5 mutant, S76A mutant, complex with monacolin J acid | 分子名称: | (3R,5R)-3,5-dihydroxy-7-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Transesterase | 著者 | Sawaya, M.R, Yeates, T.O, Pashkov, I, Gao, X, Tang, Y. | 登録日 | 2009-05-27 | 公開日 | 2009-10-27 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Directed evolution and structural characterization of a simvastatin synthase Chem.Biol., 16, 2009
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3HLF
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![BU of 3hlf by Molmil](/molmil-images/mine/3hlf) | Simvastatin Synthase (LovD), from Aspergillus terreus, S5 mutant, S76A mutant, complex with simvastatin | 分子名称: | Simvastatin acid, Transesterase | 著者 | Sawaya, M.R, Yeates, T.O, Pashkov, I, Gao, X, Tang, Y. | 登録日 | 2009-05-27 | 公開日 | 2009-10-27 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Directed evolution and structural characterization of a simvastatin synthase Chem.Biol., 16, 2009
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3HL9
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![BU of 3hl9 by Molmil](/molmil-images/mine/3hl9) | Simvastatin Synthase (LovD) from Aspergillus terreus, unliganded | 分子名称: | Transesterase | 著者 | Sawaya, M.R, Yeates, T.O, Laidman, J, Pashkov, I, Gao, X, Tang, Y. | 登録日 | 2009-05-27 | 公開日 | 2009-10-27 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Directed evolution and structural characterization of a simvastatin synthase Chem.Biol., 16, 2009
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3HLB
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![BU of 3hlb by Molmil](/molmil-images/mine/3hlb) | Simvastatin Synthase (LovD) from Aspergillus terreus, unliganded, selenomethionyl derivative | 分子名称: | SULFATE ION, Transesterase | 著者 | Sawaya, M.R, Yeates, T.O, Laidman, J, Pashkov, I, Gao, X, Tang, Y. | 登録日 | 2009-05-27 | 公開日 | 2009-10-27 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Directed evolution and structural characterization of a simvastatin synthase Chem.Biol., 16, 2009
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6LZE
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![BU of 6lze by Molmil](/molmil-images/mine/6lze) | The crystal structure of COVID-19 main protease in complex with an inhibitor 11a | 分子名称: | 3C-like proteinase, DIMETHYL SULFOXIDE, ~{N}-[(2~{S})-3-cyclohexyl-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]propan-2-yl]-1~{H}-indole-2-carboxamide | 著者 | Zhang, B, Zhang, Y, Jing, Z, Liu, X, Yang, H, Liu, H, Rao, Z, Jiang, H. | 登録日 | 2020-02-19 | 公開日 | 2020-04-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.505 Å) | 主引用文献 | Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease. Science, 368, 2020
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4E0U
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![BU of 4e0u by Molmil](/molmil-images/mine/4e0u) | Crystal structure of CdpNPT in complex with thiolodiphosphate and (S)-benzodiazependione | 分子名称: | (3S)-3-(1H-indol-3-ylmethyl)-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione, 1,2-ETHANEDIOL, Cyclic dipeptide N-prenyltransferase, ... | 著者 | Schuller, J.M, Zocher, G, Stehle, T. | 登録日 | 2012-03-05 | 公開日 | 2012-05-30 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure and catalytic mechanism of a cyclic dipeptide prenyltransferase with broad substrate promiscuity. J.Mol.Biol., 422, 2012
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