3HLE
Simvastatin Synthase (LovD), from Aspergillus terreus, S5 mutant, S76A mutant, complex with monacolin J acid
Summary for 3HLE
Entry DOI | 10.2210/pdb3hle/pdb |
Related | 1HLD |
Descriptor | Transesterase, (3R,5R)-3,5-dihydroxy-7-[(1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... (4 entities in total) |
Functional Keywords | alpha/beta hydrolase fold, transferase |
Biological source | Aspergillus terreus |
Total number of polymer chains | 1 |
Total formula weight | 48640.35 |
Authors | Sawaya, M.R.,Yeates, T.O.,Pashkov, I.,Gao, X.,Tang, Y. (deposition date: 2009-05-27, release date: 2009-10-27, Last modification date: 2023-09-06) |
Primary citation | Gao, X.,Xie, X.,Pashkov, I.,Sawaya, M.R.,Laidman, J.,Zhang, W.,Cacho, R.,Yeates, T.O.,Tang, Y. Directed evolution and structural characterization of a simvastatin synthase Chem.Biol., 16:1064-1074, 2009 Cited by PubMed: 19875080DOI: 10.1016/j.chembiol.2009.09.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.06 Å) |
Structure validation
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