8X1N
| Cryo-EM structure of human alpha-fetoprotein | 分子名称: | Alpha-fetoprotein, PALMITIC ACID, ZINC ION, ... | 著者 | Liu, Z.M, Li, M.S, Wu, C, Liu, K. | 登録日 | 2023-11-08 | 公開日 | 2024-05-15 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (3.31 Å) | 主引用文献 | Structural characteristics of alpha-fetoprotein, including N-glycosylation, metal ion and fatty acid binding sites. Commun Biol, 7, 2024
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5VAP
| Crystal structure of eVP30 C-terminus and eNP peptide | 分子名称: | Minor nucleoprotein VP30, NP | 著者 | XU, W, WU, C, Leung, D.W, Amarasinghe, G.K. | 登録日 | 2017-03-27 | 公開日 | 2017-06-21 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis. Nat Commun, 8, 2017
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4M6B
| Crystal structure of yeast Swr1-Z domain in complex with H2A.Z-H2B dimer | 分子名称: | Chimera protein of Histone H2B.1 and Histone H2A.Z, Helicase SWR1 | 著者 | Hong, J.J, Feng, H.Q, Wang, F, Ranjan, A, Chen, J.H, Jiang, J.S, Girlando, R, Xiao, T.S, Wu, C, Bai, Y.W. | 登録日 | 2013-08-09 | 公開日 | 2014-02-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | The Catalytic Subunit of the SWR1 Remodeler Is a Histone Chaperone for the H2A.Z-H2B Dimer. Mol.Cell, 53, 2014
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7V3P
| Cryo-EM structure of the IGF1R/insulin complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, Insulin B chain, ... | 著者 | Zhang, J, Liu, C, Zhang, X, Wei, T, Wu, C. | 登録日 | 2021-08-11 | 公開日 | 2022-08-17 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Cryo-EM structure of the IGF1R/insulin complex To Be Published
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7YDX
| Crystal structure of human RIPK1 kinase domain in complex with compound RI-962 | 分子名称: | 1-methyl-5-[2-(2-methylpropanoylamino)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-N-[(1S)-1-phenylethyl]indole-3-carboxamide, IODIDE ION, Receptor-interacting serine/threonine-protein kinase 1 | 著者 | Zhang, L, Wang, Y, Li, Y, Wu, C, Luo, X, Wang, T, Lei, J, Yang, S. | 登録日 | 2022-07-04 | 公開日 | 2023-04-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.642 Å) | 主引用文献 | Generative deep learning enables the discovery of a potent and selective RIPK1 inhibitor. Nat Commun, 13, 2022
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2LAS
| Molecular Determinants of Paralogue-Specific SUMO-SIM Recognition | 分子名称: | M-IR2_peptide, Small ubiquitin-related modifier 1 | 著者 | Namanja, A, Li, Y, Su, Y, Wong, S, Lu, J, Colson, L, Wu, C, Li, S, Chen, Y. | 登録日 | 2011-03-20 | 公開日 | 2011-12-14 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Insights into High Affinity Small Ubiquitin-like Modifier (SUMO) Recognition by SUMO-interacting Motifs (SIMs) Revealed by a Combination of NMR and Peptide Array Analysis. J.Biol.Chem., 287, 2012
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2L5A
| Structural basis for recognition of centromere specific histone H3 variant by nonhistone Scm3 | 分子名称: | Histone H3-like centromeric protein CSE4, Protein SCM3, Histone H4 | 著者 | Zhou, Z, Feng, H, Zhou, B, Ghirlando, R, Hu, K, Zwolak, A, Jenkins, L, Xiao, H, Tjandra, N, Wu, C, Bai, Y. | 登録日 | 2010-10-28 | 公開日 | 2011-03-16 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural basis for recognition of centromere histone variant CenH3 by the chaperone Scm3. Nature, 472, 2011
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2K2R
| The NMR structure of alpha-parvin CH2/paxillin LD1 complex | 分子名称: | Alpha-parvin, Paxillin | 著者 | Wang, X, Fukuda, K, Byeon, I, Velyvis, A, Wu, C, Gronenborn, A, Qin, J. | 登録日 | 2008-04-10 | 公開日 | 2008-05-27 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | The Structure of {alpha}-Parvin CH2-Paxillin LD1 Complex Reveals a Novel Modular Recognition for Focal Adhesion Assembly. J.Biol.Chem., 283, 2008
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2JSS
| NMR structure of chaperone Chz1 complexed with histone H2A.Z-H2B | 分子名称: | Chimera of Histone H2B.1 and Histone H2A.Z, Uncharacterized protein YER030W | 著者 | Zhou, Z, Feng, H, Hansen, D.F, Kato, H, Luk, E, Freedberg, D.I, Kay, L.E, Wu, C, Bai, Y. | 登録日 | 2007-07-11 | 公開日 | 2008-05-20 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR structure of chaperone Chz1 complexed with histones H2A.Z-H2B. Nat.Struct.Mol.Biol., 15, 2008
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7CJT
| Crystal Structure of SETDB1 Tudor domain in complexed with (R,R)-59 | 分子名称: | 2-[[(3~{R},5~{R})-1-methyl-5-(4-phenylmethoxyphenyl)piperidin-3-yl]amino]-3-prop-2-enyl-5~{H}-pyrrolo[3,2-d]pyrimidin-4-one, Histone-lysine N-methyltransferase SETDB1 | 著者 | Guo, Y.P, Liang, X, Mao, X, Wu, C, Luyi, H, Yang, S. | 登録日 | 2020-07-13 | 公開日 | 2021-04-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.474 Å) | 主引用文献 | Structure-Guided Discovery of a Potent and Selective Cell-Active Inhibitor of SETDB1 Tudor Domain. Angew.Chem.Int.Ed.Engl., 60, 2021
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7CD9
| Crystal Structure of SETDB1 tudor domain in complexed with Compound 6 | 分子名称: | 3-methyl-2-[[(3R,5R)-1-methyl-5-(4-phenylmethoxyphenyl)piperidin-3-yl]amino]-5H-pyrrolo[3,2-d]pyrimidin-4-one, CITRIC ACID, Histone-lysine N-methyltransferase SETDB1 | 著者 | Xiong, L, Guo, Y, Mao, X, Huang, L, Wu, C, Yang, S. | 登録日 | 2020-06-19 | 公開日 | 2021-04-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure-Guided Discovery of a Potent and Selective Cell-Active Inhibitor of SETDB1 Tudor Domain. Angew.Chem.Int.Ed.Engl., 60, 2021
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7ELY
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7DAD
| EPD in complex with tubulin | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ... | 著者 | Wang, Y, Wu, C. | 登録日 | 2020-10-16 | 公開日 | 2021-03-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | High-resolution X-ray structure of three microtubule-stabilizing agents in complex with tubulin provide a rationale for drug design. Biochem.Biophys.Res.Commun., 534, 2021
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7XGD
| Cryo-EM structure of Apo-IGF1R map 1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor 1 receptor | 著者 | Zhang, X, Wu, C. | 登録日 | 2022-04-04 | 公開日 | 2023-04-12 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Cryo-EM structure of Apo-IGF1R To Be Published
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7YIM
| Cryo-EM structure of human Alpha-fetoprotein | 分子名称: | Alpha-fetoprotein | 著者 | Liu, N, Liu, K, Wu, C, Liu, Z, Li, M, Wang, J, Wang, H.W. | 登録日 | 2022-07-17 | 公開日 | 2023-01-18 | 最終更新日 | 2023-01-25 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Uniform thin ice on ultraflat graphene for high-resolution cryo-EM. Nat.Methods, 20, 2023
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7B1R
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7YRN
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3J08
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3J09
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9C2F
| Structure of Calcium-Sensing Receptor in complex with positive allosteric modulator '54149 | 分子名称: | (1R)-1-(2H-1,3-benzodioxol-4-yl)-N-[2-(1,2-benzothiazol-3-yl)ethyl]ethan-1-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Wu, C, Skiniotis, G. | 登録日 | 2024-05-30 | 公開日 | 2024-10-02 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Large library docking identifies positive allosteric modulators of the calcium-sensing receptor. Science, 385, 2024
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9C1P
| Structure of Calcium-Sensing Receptor in complex with positive allosteric modulator '6218 | 分子名称: | (5R)-N-[2-(1,2-benzothiazol-3-yl)ethyl]-1-methyl-2,3,4,5-tetrahydro-1H-1-benzazepin-5-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Wu, C, Skiniotis, G. | 登録日 | 2024-05-29 | 公開日 | 2024-10-02 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Large library docking identifies positive allosteric modulators of the calcium-sensing receptor. Science, 385, 2024
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5W0W
| Crystal structure of Protein Phosphatase 2A bound to TIPRL | 分子名称: | MANGANESE (II) ION, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, ... | 著者 | Wu, C, Zheng, A, Li, J, Satyshur, K, Xing, Y. | 登録日 | 2017-06-01 | 公開日 | 2018-01-17 | 最終更新日 | 2020-01-01 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Methylation-regulated decommissioning of multimeric PP2A complexes. Nat Commun, 8, 2017
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5W0X
| Crystal structure of mouse TOR signaling pathway regulator-like (TIPRL) delta 94-103 | 分子名称: | TIP41-like protein | 著者 | Wu, C, Zheng, A, Li, J, Satyshur, K, Xing, Y. | 登録日 | 2017-06-01 | 公開日 | 2018-01-17 | 最終更新日 | 2020-01-01 | 実験手法 | X-RAY DIFFRACTION (2.717 Å) | 主引用文献 | Methylation-regulated decommissioning of multimeric PP2A complexes. Nat Commun, 8, 2017
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7CR6
| Synechocystis Cas1-Cas2/prespacer binary complex | 分子名称: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2 1, DNA (36-MER) | 著者 | Yu, Y, Chen, Q. | 登録日 | 2020-08-12 | 公開日 | 2021-03-31 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.72 Å) | 主引用文献 | Mechanisms of spacer acquisition by sequential assembly of the adaptation module in Synechocystis. Nucleic Acids Res., 49, 2021
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7CR8
| Synechocystis Cas1-Cas2-prespacerL complex | 分子名称: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2 1, DNA (36-MER) | 著者 | Yu, Y, Chen, Q. | 登録日 | 2020-08-12 | 公開日 | 2021-03-31 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | 主引用文献 | Mechanisms of spacer acquisition by sequential assembly of the adaptation module in Synechocystis. Nucleic Acids Res., 49, 2021
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