9C2F

Structure of Calcium-Sensing Receptor in complex with positive allosteric modulator '54149

This is a non-PDB format compatible entry.

Summary for 9C2F

• Entry DOI: 10.2210/pdb9c2f/pdb
• EMDB information: 45156
• Descriptor: Extracellular calcium-sensing receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: g-protein coupled receptor, calcium-sensing, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 217064.13

Authors

Wu, C.,Skiniotis, G. (deposition date: 2024-05-30, release date: 2024-10-02)

• Primary citation: Liu, F.,Wu, C.G.,Tu, C.L.,Glenn, I.,Meyerowitz, J.,Kaplan, A.L.,Lyu, J.,Cheng, Z.,Tarkhanova, O.O.,Moroz, Y.S.,Irwin, J.J.,Chang, W.,Shoichet, B.K.,Skiniotis, G.; Large library docking identifies positive allosteric modulators of the calcium-sensing receptor.; Science, 385:eado1868-eado1868, 2024; PubMed: 39298584; DOI: 10.1126/science.ado1868

Experimental method

ELECTRON MICROSCOPY (2.8 Å)