Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9C2F

Structure of Calcium-Sensing Receptor in complex with positive allosteric modulator '54149

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0016020	cellular_component	membrane
B	0004930	molecular_function	G protein-coupled receptor activity
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00979
Number of Residues	19
Details	G_PROTEIN_RECEP_F3_1 G-protein coupled receptors family 3 signature 1. VaNLLgLFyIPQVSyASSS

Chain	Residue	Details
B	VAL153-SER171
A	VAL153-SER171

site_id	PS00980
Number of Residues	25
Details	G_PROTEIN_RECEP_F3_2 G-protein coupled receptors family 3 signature 2. CCFeCveCpdgeYsdet.DasACnkC

Chain	Residue	Details
B	CYS561-CYS585
A	CYS561-CYS585

site_id	PS00981
Number of Residues	11
Details	G_PROTEIN_RECEP_F3_3 G-protein coupled receptors family 3 signature 3. FNEAKfITFSM

Chain	Residue	Details
B	PHE801-MET811
A	PHE801-MET811

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	50
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	52
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	38
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	62
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	46
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	38
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	44
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	270
Details	Region: {"description":"Ligand-binding 2 (LB2)","evidences":[{"source":"PubMed","id":"17360426","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	140
Details	Region: {"description":"Cysteine-rich (CR)","evidences":[{"source":"PubMed","id":"17360426","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	22
Details	Region: {"description":"Intracellular loop 1 (ICL1)","evidences":[{"source":"PubMed","id":"38632411","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	30
Details	Region: {"description":"Intracellular loop 3 (ICL3)","evidences":[{"source":"PubMed","id":"38632411","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27386547","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5FBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38326620","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27386547","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5FBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SZF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38326620","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27386547","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5FBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SZF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34467854","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7E6T","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27386547","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33603117","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DTU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27386547","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33603117","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38326620","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DTU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DTV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SZG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27386547","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33603117","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38326620","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DTU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SZG","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34467854","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7E6T","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33603117","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34467854","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DTT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7E6T","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38326620","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SZF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27386547","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FBH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33603117","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34194040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38326620","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5K5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7DTT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7M3G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8SZF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	2
Details	Site: {"description":"Important for ability of agonist AMG 416 to activate G-protein-coupled receptor activity","evidences":[{"source":"PubMed","id":"26290606","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	10
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33603117","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7DTT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27434672","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)