8I13
| Cryo-EM structure of 6-subunit Smc5/6 | 分子名称: | MMS21 isoform 1, NSE3 isoform 1, Non-structural maintenance of chromosomes element 1 homolog, ... | 著者 | Qian, L, Jun, Z, Xiang, Z, Cheng, T, Zhaoning, W, Duo, J, Zhenguo, C, Wang, L. | 登録日 | 2023-01-12 | 公開日 | 2024-06-26 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (6.9 Å) | 主引用文献 | Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms. Nat.Struct.Mol.Biol., 2024
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8I4X
| Cryo-EM structure of 5-subunit Smc5/6 | 分子名称: | E3 SUMO-protein ligase MMS21, Non-structural maintenance of chromosome element 5, Nse6, ... | 著者 | Qian, L, Jun, Z, Xiang, Z, Zhaoning, W, Tong, C, Duo, J, Zhenguo, C, Wang, L. | 登録日 | 2023-01-21 | 公開日 | 2024-06-26 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (8.5 Å) | 主引用文献 | Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms. Nat.Struct.Mol.Biol., 2024
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8GVK
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8SJ7
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8GRA
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8ZF1
| Crystal structure of a Chemo Triplet Photoenzyme (CTPe) | 分子名称: | N-(9-oxidanylidenethioxanthen-2-yl)ethanamide, Transcriptional regulator, PadR-like family | 著者 | Chen, X, Qian, J.Y, Guo, J, Wu, Y.Z, Zhong, F.R. | 登録日 | 2024-05-07 | 公開日 | 2024-07-17 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Chemogenetic Evolution of Diversified Photoenzymes for Enantioselective [2 + 2] Cycloadditions in Whole Cells. J.Am.Chem.Soc., 2024
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8GVL
| PTPN21 FERM | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Tyrosine-protein phosphatase non-receptor type 21 | 著者 | Chen, L, Zheng, Y.Y, Zhou, C. | 登録日 | 2022-09-15 | 公開日 | 2023-09-20 | 最終更新日 | 2024-04-17 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity. Sci Adv, 10, 2024
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8GWH
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8GVV
| PTPN21 PTP domain C1108S mutant | 分子名称: | IODIDE ION, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 21 | 著者 | Chen, L, Zheng, Y.Y, Zhou, C. | 登録日 | 2022-09-15 | 公開日 | 2023-09-20 | 最終更新日 | 2024-04-17 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity. Sci Adv, 10, 2024
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8GXE
| PTPN21 FERM PTP complex | 分子名称: | CHLORIDE ION, Tyrosine-protein phosphatase non-receptor type 21 | 著者 | Chen, L, Zheng, Y.Y, Zhou, C. | 登録日 | 2022-09-19 | 公開日 | 2023-09-27 | 最終更新日 | 2024-04-17 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity. Sci Adv, 10, 2024
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8GBN
| Structure of Apo Human SIRT5 P114T Mutant | 分子名称: | 1,2-ETHANEDIOL, NAD-dependent protein deacylase sirtuin-5, mitochondrial, ... | 著者 | Petrunak, E.M, Stuckey, J.A. | 登録日 | 2023-02-26 | 公開日 | 2024-06-05 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Human SIRT5 variants with reduced stability and activity do not cause neuropathology in mice. Iscience, 27, 2024
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8GBL
| Structure of Apo Human SIRT5 | 分子名称: | NAD-dependent protein deacylase sirtuin-5, mitochondrial, ZINC ION | 著者 | Petrunak, E.M, Stuckey, J.A. | 登録日 | 2023-02-26 | 公開日 | 2024-06-05 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | 主引用文献 | Human SIRT5 variants with reduced stability and activity do not cause neuropathology in mice. Iscience, 27, 2024
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8KCI
| ATP-bound hMRP5 outward-open | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 5, MAGNESIUM ION | 著者 | Liu, Z.M, Huang, Y. | 登録日 | 2023-08-07 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.94 Å) | 主引用文献 | Inhibition and transport mechanisms of the ABC transporter hMRP5. Nat Commun, 15, 2024
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7WN0
| Structure of PfENT1(Y190A) in complex with nanobody 19 | 分子名称: | Equilibrative nucleoside/nucleobase transporter, nanobody19 | 著者 | Wang, C, Deng, D, Ren, R.B, Yu, L.Y. | 登録日 | 2022-01-17 | 公開日 | 2023-02-01 | 最終更新日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (3.64 Å) | 主引用文献 | Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1. Nat Commun, 14, 2023
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5X83
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4RT4
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5DD1
| Crystal structures in an anti-HIV antibody lineage from immunization of Rhesus macaques | 分子名称: | ANTI-HIV ANTIBODY DH570 FAB HEAVY CHAIN, ANTI-HIV ANTIBODY DH570 FAB LIGHT CHAIN | 著者 | Zhang, R, Verkoczy, L, Wiehe, K, Alam, S.M, Nicely, N.I, Santra, S, Bradley, T, Pemble, C, Gao, F, Montefiori, D.C, Bouton-Verville, H, Kelsoe, G, Parks, R, Foulger, A, Tomaras, G, Keple, T.B, Moody, M.A, Liao, H.-X, Haynes, B.F. | 登録日 | 2015-08-24 | 公開日 | 2016-05-11 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.597 Å) | 主引用文献 | Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages. Sci Transl Med, 8, 2016
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8AWI
| Crystal structure of Human Transthyretin at 1.15 Angstrom resolution | 分子名称: | SODIUM ION, Transthyretin | 著者 | Derbyshire, D.J, Hammarstrom, P, von Castelmur, E, Begum, A. | 登録日 | 2022-08-29 | 公開日 | 2023-03-01 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Transthyretin Binding Mode Dichotomy of Fluorescent trans -Stilbene Ligands. Acs Chem Neurosci, 14, 2023
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3B5H
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7ZJ6
| X-31 Hemagglutinin Precursor HA0 at pH 7.5 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin,Fibritin, ... | 著者 | Garcia-Moro, E, Rosenthal, P.B. | 登録日 | 2022-04-08 | 公開日 | 2022-08-17 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Reversible structural changes in the influenza hemagglutinin precursor at membrane fusion pH. Proc.Natl.Acad.Sci.USA, 119, 2022
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7ZJ7
| X-31 Hemagglutinin Precursor HA0 at pH 4.8 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin,Fibritin, ... | 著者 | Garcia-Moro, E, Rosenthal, P.B. | 登録日 | 2022-04-08 | 公開日 | 2022-08-17 | 実験手法 | ELECTRON MICROSCOPY (3.95 Å) | 主引用文献 | Reversible structural changes in the influenza hemagglutinin precursor at membrane fusion pH. Proc.Natl.Acad.Sci.USA, 119, 2022
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7ZJ8
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2HAL
| An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors | 分子名称: | Hepatitis A Protease 3C, N-ACETYL-LEUCYL-PHENYLALANYL-PHENYLALANYL-GLUTAMATE-FLUOROMETHYLKETONE INHIBITOR, N-[(BENZYLOXY)CARBONYL]-L-ALANINE | 著者 | Yin, J, Cherney, M.M, Bergmann, E.M, James, M.N. | 登録日 | 2006-06-13 | 公開日 | 2006-08-08 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | An Episulfide Cation (Thiiranium Ring) Trapped in the Active Site of HAV 3C Proteinase Inactivated by Peptide-based Ketone Inhibitors. J.Mol.Biol., 361, 2006
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4RTA
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7YDQ
| Structure of PfNT1(Y190A)-GFP in complex with GSK4 | 分子名称: | 5-methyl-N-[2-(2-oxidanylideneazepan-1-yl)ethyl]-2-phenyl-1,3-oxazole-4-carboxamide, Nucleoside transporter 1,Green fluorescent protein | 著者 | Wang, C, Yu, L.Y, Li, J.L, Ren, R.B, Deng, D. | 登録日 | 2022-07-04 | 公開日 | 2023-04-26 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (4.04 Å) | 主引用文献 | Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1. Nat Commun, 14, 2023
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