8GBL

Structure of Apo Human SIRT5

Summary for 8GBL

• Entry DOI: 10.2210/pdb8gbl/pdb
• Descriptor: NAD-dependent protein deacylase sirtuin-5, mitochondrial, ZINC ION (3 entities in total)
• Functional Keywords: deacetylase, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 59216.35

Authors

Petrunak, E.M.,Stuckey, J.A. (deposition date: 2023-02-26, release date: 2024-06-05, Last modification date: 2024-06-19)

• Primary citation: Yuan, T.,Kumar, S.,Skinner, M.E.,Victor-Joseph, R.,Abuaita, M.,Keijer, J.,Zhang, J.,Kunkel, T.J.,Liu, Y.,Petrunak, E.M.,Saunders, T.L.,Lieberman, A.P.,Stuckey, J.A.,Neamati, N.,Al-Murshedi, F.,Alfadhel, M.,Spelbrink, J.N.,Rodenburg, R.,de Boer, V.C.J.,Lombard, D.B.; Human SIRT5 variants with reduced stability and activity do not cause neuropathology in mice.; Iscience, 27:109991-109991, 2024; PubMed: 38846003; DOI: 10.1016/j.isci.2024.109991

Experimental method

X-RAY DIFFRACTION (2.24 Å)