8GBN
Structure of Apo Human SIRT5 P114T Mutant
Summary for 8GBN
Entry DOI | 10.2210/pdb8gbn/pdb |
Descriptor | NAD-dependent protein deacylase sirtuin-5, mitochondrial, ZINC ION, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | deacetylase, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 59348.47 |
Authors | Petrunak, E.M.,Stuckey, J.A. (deposition date: 2023-02-26, release date: 2024-06-05, Last modification date: 2024-06-19) |
Primary citation | Yuan, T.,Kumar, S.,Skinner, M.E.,Victor-Joseph, R.,Abuaita, M.,Keijer, J.,Zhang, J.,Kunkel, T.J.,Liu, Y.,Petrunak, E.M.,Saunders, T.L.,Lieberman, A.P.,Stuckey, J.A.,Neamati, N.,Al-Murshedi, F.,Alfadhel, M.,Spelbrink, J.N.,Rodenburg, R.,de Boer, V.C.J.,Lombard, D.B. Human SIRT5 variants with reduced stability and activity do not cause neuropathology in mice. Iscience, 27:109991-109991, 2024 Cited by PubMed: 38846003DOI: 10.1016/j.isci.2024.109991 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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