7EW0
| Cryo-EM structure of ozanimod -bound Sphingosine-1-phosphate receptor 1 in complex with Gi protein | 分子名称: | 5-[3-[(1~{S})-1-(2-hydroxyethylamino)-2,3-dihydro-1~{H}-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-propan-2-yloxy-benzenecarbonitrile, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yuan, Y, Jia, G.W, Su, Z.M, Shao, Z.H. | 登録日 | 2021-05-24 | 公開日 | 2021-09-29 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.42 Å) | 主引用文献 | Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition. Cell Res., 31, 2021
|
|
7EVZ
| Cryo-EM structure of cenerimod -bound Sphingosine-1-phosphate receptor 1 in complex with Gi protein | 分子名称: | (2~{S})-3-[4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-1,2,4-oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy]propane-1,2-diol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yuan, Y, Jia, G.W, Shao, Z.H, Su, Z.M. | 登録日 | 2021-05-24 | 公開日 | 2021-09-29 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition. Cell Res., 31, 2021
|
|
7EVY
| Cryo-EM structure of siponimod -bound Sphingosine-1-phosphate receptor 1 in complex with Gi protein | 分子名称: | 1-[[4-[(~{E})-~{N}-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-~{C}-methyl-carbonimidoyl]-2-ethyl-phenyl]methyl]azetidine-3-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Jia, G.W, Yuan, Y, Su, Z.M, Shao, Z.H. | 登録日 | 2021-05-24 | 公開日 | 2021-09-29 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition. Cell Res., 31, 2021
|
|
7EW7
| Cryo-EM structure of SEW2871-bound Sphingosine-1-phosphate receptor 1 in complex with Gi protein | 分子名称: | 5-[4-phenyl-5-(trifluoromethyl)thiophen-2-yl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Jia, G.W, Yuan, Y, Su, Z.M, Shao, Z.H. | 登録日 | 2021-05-24 | 公開日 | 2021-09-29 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | 主引用文献 | Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition. Cell Res., 31, 2021
|
|
7VR1
| |
7W1Y
| Human MCM double hexamer bound to natural DNA duplex (polyAT/polyTA) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (49-MER), ... | 著者 | Li, J, Dong, J, Dang, S, Zhai, Y. | 登録日 | 2021-11-21 | 公開日 | 2023-02-08 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (2.59 Å) | 主引用文献 | The human pre-replication complex is an open complex. Cell, 186, 2023
|
|
7W7Y
| The crystal structure of human abl1 kinase domain in complex with ABL2-A5 | 分子名称: | 5-[3-(5-methanoyl-2-methoxy-4-oxidanyl-phenyl)-1~{H}-pyrrolo[2,3-b]pyridin-5-yl]-~{N},~{N}-dimethyl-pyridine-3-carboxamide, Tyrosine-protein kinase ABL1 | 著者 | Zhu, C, Zhang, Z.M. | 登録日 | 2021-12-06 | 公開日 | 2022-04-27 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.20003033 Å) | 主引用文献 | Cell-Active, Reversible, and Irreversible Covalent Inhibitors That Selectively Target the Catalytic Lysine of BCR-ABL Kinase. Angew.Chem.Int.Ed.Engl., 61, 2022
|
|
7W7X
| The crystal structure of human abl1 kinase domain in complex with ABL1-A11 | 分子名称: | 5-[5-(dimethylcarbamoyl)pyridin-3-yl]-3-(5-fluorosulfonyloxy-2-methoxy-phenyl)-1H-pyrrolo[2,3-b]pyridine, Tyrosine-protein kinase ABL1 | 著者 | Zhu, C, Zhang, Z.M. | 登録日 | 2021-12-06 | 公開日 | 2022-04-27 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.0000093 Å) | 主引用文献 | Cell-Active, Reversible, and Irreversible Covalent Inhibitors That Selectively Target the Catalytic Lysine of BCR-ABL Kinase. Angew.Chem.Int.Ed.Engl., 61, 2022
|
|
7DNU
| mRNA-decapping enzyme g5Rp with inhibitor insp6 complex | 分子名称: | INOSITOL HEXAKISPHOSPHATE, mRNA-decapping protein g5R | 著者 | Yang, Y, Chen, C, Li, L, Li, X.H, Su, D. | 登録日 | 2020-12-10 | 公開日 | 2021-12-15 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.245 Å) | 主引用文献 | Structural Insight into Molecular Inhibitory Mechanism of InsP 6 on African Swine Fever Virus mRNA-Decapping Enzyme g5Rp. J.Virol., 96, 2022
|
|
7DNT
| mRNA-decapping enzyme g5Rp | 分子名称: | mRNA-decapping protein g5R | 著者 | Yang, Y, Chen, C, Li, L, Li, X.H, Su, D. | 登録日 | 2020-12-10 | 公開日 | 2022-03-09 | 最終更新日 | 2022-12-28 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural Insight into Molecular Inhibitory Mechanism of InsP 6 on African Swine Fever Virus mRNA-Decapping Enzyme g5Rp. J.Virol., 96, 2022
|
|
7DTC
| voltage-gated sodium channel Nav1.5-E1784K | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein type 5 subunit alpha | 著者 | Yan, N, Pan, X, Li, Z. | 登録日 | 2021-01-04 | 公開日 | 2021-03-24 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure of human Na v 1.5 reveals the fast inactivation-related segments as a mutational hotspot for the long QT syndrome. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7DWQ
| Photosystem I from a chlorophyll d-containing cyanobacterium Acaryochloris marina | 分子名称: | (6'R,11cis,11'cis,13cis,15cis)-4',5'-didehydro-5',6'-dihydro-beta,beta-carotene, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ... | 著者 | Chen, J.H, Zhang, X, Shen, J.R. | 登録日 | 2021-01-17 | 公開日 | 2021-06-02 | 最終更新日 | 2021-10-20 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | A unique photosystem I reaction center from a chlorophyll d-containing cyanobacterium Acaryochloris marina. J Integr Plant Biol, 63, 2021
|
|
7DXH
| Cryo-EM structure of PSII intermediate Psb28-PSII complex | 分子名称: | (1S)-2-(ALPHA-L-ALLOPYRANOSYLOXY)-1-[(TRIDECANOYLOXY)METHYL]ETHYL PALMITATE, 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 5-[(2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-HEPTAMETHYLOCTACOSA-2,6,10,14,18,22,26-HEPTAENYL]-2,3-DIMETHYLBENZO-1,4-QUINONE, ... | 著者 | Sui, S.F, Shen, J.R, Han, G.Y, Xiao, Y.N, Huang, G.Q. | 登録日 | 2021-01-18 | 公開日 | 2021-06-30 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | 主引用文献 | Structural insights into cyanobacterial photosystem II intermediates associated with Psb28 and Tsl0063. Nat.Plants, 7, 2021
|
|
7DXA
| PSII intermediate Psb28-RC47 | 分子名称: | (1S)-2-(ALPHA-L-ALLOPYRANOSYLOXY)-1-[(TRIDECANOYLOXY)METHYL]ETHYL PALMITATE, 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 5-[(2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-HEPTAMETHYLOCTACOSA-2,6,10,14,18,22,26-HEPTAENYL]-2,3-DIMETHYLBENZO-1,4-QUINONE, ... | 著者 | Sui, S.F, Shen, J.R, Han, G.Y, Xiao, Y.N, Huang, G.Q. | 登録日 | 2021-01-18 | 公開日 | 2021-06-30 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | 主引用文献 | Structural insights into cyanobacterial photosystem II intermediates associated with Psb28 and Tsl0063. Nat.Plants, 7, 2021
|
|
7CZL
| Structural insights into a dimeric Psb27-photosystem II complex from a cyanobacterium Thermosynechococcus vulcanus | 分子名称: | (1S)-2-(ALPHA-L-ALLOPYRANOSYLOXY)-1-[(TRIDECANOYLOXY)METHYL]ETHYL PALMITATE, 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, ... | 著者 | Pi, X, Huang, G, Xiao, Y. | 登録日 | 2020-09-09 | 公開日 | 2021-01-20 | 最終更新日 | 2021-02-10 | 実験手法 | ELECTRON MICROSCOPY (3.78 Å) | 主引用文献 | Structural insights into a dimeric Psb27-photosystem II complex from a cyanobacterium Thermosynechococcus vulcanus . Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7C4A
| nicA2 with cofactor FAD | 分子名称: | Amine oxidase, FLAVIN-ADENINE DINUCLEOTIDE | 著者 | Xu, P, Zang, K. | 登録日 | 2020-05-15 | 公開日 | 2020-06-03 | 最終更新日 | 2020-12-16 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Molecular Deceleration Regulates Toxicant Release to Prevent Cell Damage in Pseudomonas putida S16 (DSM 28022). Mbio, 11, 2020
|
|
7C49
| nicA2 with cofactor FAD and substrate nicotine | 分子名称: | 5-[(2S)-1-methylpyrrolidin-2-yl]pyridin-2-ol, Amine oxidase, FLAVIN-ADENINE DINUCLEOTIDE | 著者 | Xu, P, Zhang, K. | 登録日 | 2020-05-15 | 公開日 | 2020-06-03 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Molecular Deceleration Regulates Toxicant Release to Prevent Cell Damage in Pseudomonas putida S16 (DSM 28022). Mbio, 11, 2020
|
|
2LW3
| Solution structure of the soluble domain of MmpS4 from Mycobacterium tuberculosis | 分子名称: | Putative membrane protein mmpS4 | 著者 | Xi, Z, Sun, P, Wang, W, Lai, C, Wu, F, Tian, C. | 登録日 | 2012-07-19 | 公開日 | 2013-03-13 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Discovery of a Siderophore Export System Essential for Virulence of Mycobacterium tuberculosis Plos Pathog., 9, 2013
|
|
7VMU
| Crystal Structure of SARS-CoV Spike Receptor-Binding Domain Complexed with Neutralizing Antibody | 分子名称: | Spike protein S1, scFv E4 | 著者 | Guo, Y, Wang, W, Jiao, P, Yang, H, Rao, Z, Cheng, G. | 登録日 | 2021-10-09 | 公開日 | 2021-11-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | 主引用文献 | Antibody engineering improves neutralization activity against K417 spike mutant SARS-CoV-2 variants. Cell Biosci, 12, 2022
|
|
8TQ1
| HIV-1 BG505 Env SOSIP in complex with bovine Fab Bess4 and non-human primate Fab RM20A3 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Bovine Bess4 Fab heavy chain, ... | 著者 | Ozorowski, G, Lee, W.H, Ward, A.B. | 登録日 | 2023-08-06 | 公開日 | 2024-08-07 | 最終更新日 | 2024-10-02 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Immunization of cows with HIV envelope trimers generates broadly neutralizing antibodies to the V2-apex from the ultralong CDRH3 repertoire. Plos Pathog., 20, 2024
|
|
6DVK
| Computationally designed mini tetraloop-tetraloop receptor by the RNAMake program - construct 6 (miniTTR 6) | 分子名称: | COBALT (II) ION, MAGNESIUM ION, RNA (95-MER) | 著者 | Eiler, D.R, Yesselman, J.D, Costantino, D.A, Das, R, Kieft, J.S. | 登録日 | 2018-06-24 | 公開日 | 2019-06-26 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Computational design of three-dimensional RNA structure and function. Nat Nanotechnol, 14, 2019
|
|
8ECQ
| Bovine Fab 2G3 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2G3 Fab Heavy chain, 2G3 Fab Light chain, ... | 著者 | Stanfield, R.L, Wilson, I.A. | 登録日 | 2022-09-02 | 公開日 | 2023-09-20 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The smallest functional antibody fragment: Ultralong CDR H3 antibody knob regions potently neutralize SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
8ECZ
| Bovine Fab 4C1 | 分子名称: | 4C1 Fab heavy chain, 4C1 Fab light chain, PHOSPHATE ION | 著者 | Stanfield, R.L, Wilson, I.A. | 登録日 | 2022-09-02 | 公開日 | 2023-09-20 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.82 Å) | 主引用文献 | The smallest functional antibody fragment: Ultralong CDR H3 antibody knob regions potently neutralize SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
8ECV
| Bovine Fab 2F12 | 分子名称: | 2F12 Fab Heavy chain, 2F12 Fab Light chain | 著者 | Stanfield, R.L, Wilson, I.A. | 登録日 | 2022-09-02 | 公開日 | 2023-09-20 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | The smallest functional antibody fragment: Ultralong CDR H3 antibody knob regions potently neutralize SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
8ED1
| Bovine Fab 5C1 | 分子名称: | 5C1 Fab heavy chain, 5C1 Fab light chain, GLYCEROL, ... | 著者 | Stanfield, R.L, Wilson, I.A. | 登録日 | 2022-09-02 | 公開日 | 2023-09-20 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | The smallest functional antibody fragment: Ultralong CDR H3 antibody knob regions potently neutralize SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|