8XKI
| A neutralizing nanobody VHH60 against wt SARS-CoV-2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Lu, Y, Guo, H, Ji, X, Yang, H. | 登録日 | 2023-12-23 | 公開日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | A broad neutralizing nanobody against SARS-CoV-2 engineered from an approved drug. Cell Death Dis, 15, 2024
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8VZO
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8VZN
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8QAU
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3EZK
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8T6B
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8T69
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8T6A
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3FSS
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8Q85
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3DWR
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8PPR
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4DLP
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3DWS
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4G1F
| Crystal Structure of human Dipeptidyl Peptidase IV in complex with a pyridopyrimidinedione analogue | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-amino-6-(aminomethyl)-5-(2-bromophenyl)-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione, ... | 著者 | Skene, R.J, Gwaltney, S.L. | 登録日 | 2012-07-10 | 公開日 | 2013-02-27 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
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7TP3
| Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody K288.2 | 分子名称: | CACODYLATE ION, K288.2 heavy chain, K288.2 light chain, ... | 著者 | Yuan, M, Zhu, X, Wilson, I.A. | 登録日 | 2022-01-24 | 公開日 | 2022-02-23 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques. Sci Transl Med, 14, 2022
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7TLX
| Crystal Structure of cytochrome c from Pseudomonas putida S16 | 分子名称: | C-type cytochrome, HEME C | 著者 | Wu, K, Dulchavsky, M, Stull, F, Bardwell, J.C.A. | 登録日 | 2022-01-19 | 公開日 | 2022-04-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The enzyme pseudooxynicotine amine oxidase from Pseudomonas putida S16 is not an oxidase, but a dehydrogenase. J.Biol.Chem., 298, 2022
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7U5K
| Cryo-EM Structure of DPYSL2 | 分子名称: | Dihydropyrimidinase-related protein 2 | 著者 | Morgan, C.E, Yu, E.W. | 登録日 | 2022-03-02 | 公開日 | 2022-12-14 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.78 Å) | 主引用文献 | Toward structural-omics of the bovine retinal pigment epithelium. Cell Rep, 41, 2022
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7U0R
| Crystal structure of Methanomethylophilus alvus PylRS(N166A/V168A) complexed with meta-trifluoromethyl-2-benzylmalonate and AMP-PNP | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Swenson, C.V, Roe, L.T, Fricke, R.C.B, Smaga, S.S, Gee, C.L, Schepartz, A. | 登録日 | 2022-02-18 | 公開日 | 2023-06-14 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase enzymes to include non-alpha-amino acids in vitro and in vivo. Nat.Chem., 15, 2023
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7U6L
| Pseudooxynicotine amine oxidase | 分子名称: | Amine oxidase, FLAVIN-ADENINE DINUCLEOTIDE | 著者 | Choudhary, V, Stull, F, Wu, K. | 登録日 | 2022-03-04 | 公開日 | 2022-07-20 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | The enzyme pseudooxynicotine amine oxidase from Pseudomonas putida S16 is not an oxidase, but a dehydrogenase. J.Biol.Chem., 298, 2022
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7UG2
| Crystal structure of the coiled-coil domain of TRIM75 | 分子名称: | ACETYL GROUP, ISOPROPYL ALCOHOL, Tripartite motif-containing protein 75 | 著者 | Lou, X.H, Ma, B.B, Zhuang, Y, Li, X.C. | 登録日 | 2022-03-23 | 公開日 | 2023-02-15 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.052 Å) | 主引用文献 | Structural studies of the coiled-coil domain of TRIM75 reveal a tetramer architecture facilitating its E3 ligase complex. Comput Struct Biotechnol J, 20, 2022
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7TP4
| Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody K398.22 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, K398.22 heavy chain, ... | 著者 | Yuan, M, Zhu, X, Wilson, I.A. | 登録日 | 2022-01-24 | 公開日 | 2022-02-23 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques. Sci Transl Med, 14, 2022
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7EQ2
| Crystal structure of GDP-bound Rab1a-T75D | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, COBALT HEXAMMINE(III), ... | 著者 | Cao, Y.L, Gu, D.D, Gao, S. | 登録日 | 2021-04-28 | 公開日 | 2022-11-02 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.55090284 Å) | 主引用文献 | Aurora kinase A-mediated phosphorylation triggers structural alteration of Rab1A to enhance ER complexity during mitosis Nat.Struct.Mol.Biol., 2024
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7EO7
| Crystal structure of HCoV-NL63 3C-like protease in complex with an inhibitor Shikonin | 分子名称: | 2-[(1R)-4-methyl-1-oxidanyl-pent-3-enyl]-5,8-bis(oxidanyl)naphthalene-1,4-dione, 3C-like proteinase | 著者 | Gao, H.X, Zhang, Y.T, Zhou, X.L, Zhong, F.L, Li, J, Zhang, J. | 登録日 | 2021-04-21 | 公開日 | 2021-10-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.24916625 Å) | 主引用文献 | Structure-Based Discovery and Structural Basis of a Novel Broad-Spectrum Natural Product against the Main Protease of Coronavirus. J.Virol., 96, 2022
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7EO8
| Crystal structure of SARS coronavirus main protease in complex with an inhibitor Shikonin | 分子名称: | 2-[(1R)-4-methyl-1-oxidanyl-pent-3-enyl]-5,8-bis(oxidanyl)naphthalene-1,4-dione, 3C-like proteinase | 著者 | Zhang, Y.T, Gao, H.X, Zhou, H, Zhong, F.L, Hu, X.H, Zhou, X.L, Lin, C, Wang, Q.S, Li, J, Zhang, J. | 登録日 | 2021-04-21 | 公開日 | 2021-10-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.2808516 Å) | 主引用文献 | Structure-Based Discovery and Structural Basis of a Novel Broad-Spectrum Natural Product against the Main Protease of Coronavirus. J.Virol., 96, 2022
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