8VZO

Cryo-EM structure of FLVCR2 in the outward-facing state with choline bound

Summary for 8VZO

• Entry DOI: 10.2210/pdb8vzo/pdb
• EMDB information: 43684
• Descriptor: Feline leukemia virus subgroup C cellular receptor 2, Fab FLV23 heavy chain, Fab FLV23 light chain, ... (4 entities in total)
• Functional Keywords: choline transporter, blood-brain barrier, membrane protein, mfs fold, transport protein
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 3
• Total formula weight: 109337.99

Authors

Cater, R.J.,Mancia, F. (deposition date: 2024-02-12, release date: 2024-05-01, Last modification date: 2024-05-22)

• Primary citation: Cater, R.J.,Mukherjee, D.,Gil-Iturbe, E.,Erramilli, S.K.,Chen, T.,Koo, K.,Santander, N.,Reckers, A.,Kloss, B.,Gawda, T.,Choy, B.C.,Zhang, Z.,Katewa, A.,Larpthaveesarp, A.,Huang, E.J.,Mooney, S.W.J.,Clarke, O.B.,Yee, S.W.,Giacomini, K.M.,Kossiakoff, A.A.,Quick, M.,Arnold, T.,Mancia, F.; Structural and molecular basis of choline uptake into the brain by FLVCR2.; Nature, 629:704-709, 2024; PubMed: 38693257; DOI: 10.1038/s41586-024-07326-y

Experimental method

ELECTRON MICROSCOPY (2.49 Å)