Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8VZO

Cryo-EM structure of FLVCR2 in the outward-facing state with choline bound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001701	biological_process	in utero embryonic development
A	0002040	biological_process	sprouting angiogenesis
A	0005515	molecular_function	protein binding
A	0005575	cellular_component	cellular_component
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0007005	biological_process	mitochondrion organization
A	0007420	biological_process	brain development
A	0010467	biological_process	gene expression
A	0015220	molecular_function	choline transmembrane transporter activity
A	0015232	molecular_function	heme transmembrane transporter activity
A	0015871	biological_process	choline transport
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022857	molecular_function	transmembrane transporter activity
A	0030324	biological_process	lung development
A	0031966	cellular_component	mitochondrial membrane
A	0033265	molecular_function	choline binding
A	0034228	molecular_function	ethanolamine transmembrane transporter activity
A	0034229	biological_process	ethanolamine transport
A	0046466	biological_process	membrane lipid catabolic process
A	0055085	biological_process	transmembrane transport
A	0097037	biological_process	heme export
A	0097102	biological_process	endothelial tip cell fate specification
A	0150104	biological_process	transport across blood-brain barrier

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
D	TYR193-HIS199
B	TYR213-HIS219

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=TM1","evidences":[{"source":"PubMed","id":"38693257","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VZO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	33
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"38693257","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VZO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	27
Details	Transmembrane: {"description":"Helical; Name=TM2","evidences":[{"source":"PubMed","id":"38693257","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VZO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	13
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"38693257","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VZO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=TM3","evidences":[{"source":"PubMed","id":"38693257","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VZO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	28
Details	Transmembrane: {"description":"Helical; Name=TM4","evidences":[{"source":"PubMed","id":"38693257","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VZO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=TM5","evidences":[{"source":"PubMed","id":"38693257","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VZO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	29
Details	Transmembrane: {"description":"Helical; Name=TM6","evidences":[{"source":"PubMed","id":"38693257","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VZO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	30
Details	Transmembrane: {"description":"Helical; Name=TM7","evidences":[{"source":"PubMed","id":"38693257","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VZO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	28
Details	Transmembrane: {"description":"Helical; Name=TM8","evidences":[{"source":"PubMed","id":"38693257","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VZO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=TM9","evidences":[{"source":"PubMed","id":"38693257","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VZO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	29
Details	Transmembrane: {"description":"Helical; Name=TM10","evidences":[{"source":"PubMed","id":"38693257","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VZO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=TM11","evidences":[{"source":"PubMed","id":"38693257","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VZO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=TM12","evidences":[{"source":"PubMed","id":"38693257","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VZO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38693257","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VZO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9UPI3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38693257","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VZN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)