7U0R

Crystal structure of Methanomethylophilus alvus PylRS(N166A/V168A) complexed with meta-trifluoromethyl-2-benzylmalonate and AMP-PNP

Summary for 7U0R

Entry DOI	10.2210/pdb7u0r/pdb
Descriptor	Pyrrolysyl-tRNA synthetase, {[3-(trifluoromethyl)phenyl]methyl}propanedioic acid, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (6 entities in total)
Functional Keywords	aminoacyl-trna synthetase, ligase, non-natural amino acids, pyrrolysyl-trna synthetase, translation, translation-inhibitor complex, translation/inhibitor
Biological source	Candidatus Methanomethylophilus alvus
Total number of polymer chains	2
Total formula weight	63895.01
Authors	Swenson, C.V.,Roe, L.T.,Fricke, R.C.B.,Smaga, S.S.,Gee, C.L.,Schepartz, A. (deposition date: 2022-02-18, release date: 2023-06-14, Last modification date: 2023-10-25)
Primary citation	Fricke, R.,Swenson, C.V.,Roe, L.T.,Hamlish, N.X.,Shah, B.,Zhang, Z.,Ficaretta, E.,Ad, O.,Smaga, S.,Gee, C.L.,Chatterjee, A.,Schepartz, A. Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase enzymes to include non-alpha-amino acids in vitro and in vivo. Nat.Chem., 15:960-971, 2023 Cited by PubMed: 37264106 DOI: 10.1038/s41557-023-01224-y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation