8VZN
Cryo-EM structure of FLVCR2 in the inward-facing state with choline bound
Summary for 8VZN
Entry DOI | 10.2210/pdb8vzn/pdb |
Related | 8VZO |
EMDB information | 43683 43684 |
Descriptor | Feline leukemia virus subgroup C cellular receptor 2, Fab FLV9 heavy chain, Fab FLV9 light chain, ... (4 entities in total) |
Functional Keywords | choline transporter, blood-brain barrier, membrane protein, mfs fold, transport protein |
Biological source | Mus musculus (house mouse) More |
Total number of polymer chains | 3 |
Total formula weight | 109265.99 |
Authors | Cater, R.J.,Mancia, F. (deposition date: 2024-02-12, release date: 2024-05-01, Last modification date: 2024-05-22) |
Primary citation | Cater, R.J.,Mukherjee, D.,Gil-Iturbe, E.,Erramilli, S.K.,Chen, T.,Koo, K.,Santander, N.,Reckers, A.,Kloss, B.,Gawda, T.,Choy, B.C.,Zhang, Z.,Katewa, A.,Larpthaveesarp, A.,Huang, E.J.,Mooney, S.W.J.,Clarke, O.B.,Yee, S.W.,Giacomini, K.M.,Kossiakoff, A.A.,Quick, M.,Arnold, T.,Mancia, F. Structural and molecular basis of choline uptake into the brain by FLVCR2. Nature, 629:704-709, 2024 Cited by PubMed: 38693257DOI: 10.1038/s41586-024-07326-y PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.77 Å) |
Structure validation
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