6YH2
| tRNA-guanine Transglycosylase (TGT) labeled with 5-fluorotryptophan in co-crystallized complex with 2-(methylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | 分子名称: | 2-(methylamino)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one, CHLORIDE ION, GLYCEROL, ... | 著者 | Nguyen, A, Heine, A, Klebe, G. | 登録日 | 2020-03-28 | 公開日 | 2020-04-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.19 Å) | 主引用文献 | Co-crystallization, nanoESI-MS and 19F NMR reveal dimer disturbing inhibitors and conformational changes at dimer contacts To Be Published
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4GKH
| Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor 1-NA-PP1 | 分子名称: | 1-tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, ACETATE ION, Aminoglycoside 3'-phosphotransferase AphA1-IAB, ... | 著者 | Stogios, P.J, Evdokimova, E, Wawrzak, Z, Minasov, G, Egorova, O, Di Leo, R, Shakya, T, Spanogiannopoulos, P, Todorovic, N, Capretta, A, Wright, G.D, Savchenko, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2012-08-11 | 公開日 | 2012-09-05 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.863 Å) | 主引用文献 | Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance. Biochem.J., 454, 2013
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2XE8
| The complete reaction cycle of human phosphoglycerate kinase: The open ternary complex with 3PG and AMP-PNP | 分子名称: | 3-PHOSPHOGLYCERIC ACID, PHOSPHOGLYCERATE KINASE 1, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | 著者 | Cliff, M.J, Baxter, N.J, Blackburn, G.M, Merli, A, Vas, M, Waltho, J.P, Bowler, M.W. | 登録日 | 2010-05-11 | 公開日 | 2011-01-19 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | A Spring Loaded Release Mechanism Regulates Domain Movement and Catalysis in Phosphoglycerate Kinase. J.Biol.Chem., 286, 2011
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6ZSA
| Human mitochondrial ribosome bound to mRNA, A-site tRNA and P-site tRNA | 分子名称: | 12S mitochondrial rRNA, 16S mitochondrial rRNA, 28S ribosomal protein S10, ... | 著者 | Aibara, S, Singh, V, Modelska, A, Amunts, A. | 登録日 | 2020-07-15 | 公開日 | 2020-10-21 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structural basis of mitochondrial translation. Elife, 9, 2020
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5JLV
| Receptor binding domain of Botulinum neurotoxin A in complex with human glycosylated SV2C | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | 著者 | Yao, G, Zhang, S, Mahrhold, S, Lam, K, Stern, D, Bagramyan, K, Perry, K, Kalkum, M, Rummel, A, Dong, M, Jin, R. | 登録日 | 2016-04-27 | 公開日 | 2016-06-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A. Nat.Struct.Mol.Biol., 23, 2016
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8P7A
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2O30
| Nuclear movement protein from E. cuniculi GB-M1 | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, NUCLEAR MOVEMENT PROTEIN | 著者 | Binkowski, T.A, Skarina, T, Onopriyenko, O, Savchenko, A, Edwards, A, Joachimiak, A, MCSG, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2006-11-30 | 公開日 | 2007-01-02 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Nuclear movement protein from E. cuniculi GB-M1 TO BE PUBLISHED
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2O38
| Putative XRE Family Transcriptional Regulator | 分子名称: | ACETIC ACID, Hypothetical protein | 著者 | Kim, Y, Joachimiak, A, Evdokimova, E, Kagan, O, Edwards, A, Savchenko, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2006-11-30 | 公開日 | 2007-01-02 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | The Crystal Structure of Putative XRE Family Transcriptional Regulator To be Published
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8P6V
| Cryo-EM structure of CAK in complex with inhibitor ICEC0942 | 分子名称: | (3R,4R)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol, CDK-activating kinase assembly factor MAT1, Cyclin-H, ... | 著者 | Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J. | 登録日 | 2023-05-30 | 公開日 | 2023-08-30 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (1.9 Å) | 主引用文献 | High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design. Nat Commun, 15, 2024
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1ESO
| MONOMERIC CU,ZN SUPEROXIDE DISMUTASE FROM ESCHERICHIA COLI | 分子名称: | COPPER (II) ION, CU, ZN SUPEROXIDE DISMUTASE, ... | 著者 | Pesce, A, Capasso, C, Battistoni, A, Folcarelli, S, Rotilio, G, Desideri, A, Bolognesi, M. | 登録日 | 1997-06-27 | 公開日 | 1998-07-01 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Unique structural features of the monomeric Cu,Zn superoxide dismutase from Escherichia coli, revealed by X-ray crystallography. J.Mol.Biol., 274, 1997
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8OK0
| Crystal structure of human NQO1 in complex with the inhibitor PMSF | 分子名称: | ACETYL GROUP, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | 著者 | Martin-Garcia, J.M, Grieco, A, Ruiz-Fresneda, M.A. | 登録日 | 2023-03-26 | 公開日 | 2023-11-01 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural dynamics at the active site of the cancer-associated flavoenzyme NQO1 probed by chemical modification with PMSF. Febs Lett., 597, 2023
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5JDA
| Bacillus cereus CotH kinase plus Mg2+/AMP | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, ... | 著者 | Tomchick, D.R, Tagliabracci, V.S, Sreelatha, A. | 登録日 | 2016-04-15 | 公開日 | 2016-05-18 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.401 Å) | 主引用文献 | Phosphorylation of spore coat proteins by a family of atypical protein kinases. Proc.Natl.Acad.Sci.USA, 113, 2016
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4BCW
| Carbonic anhydrase IX mimic in complex with (E)-2-(5-bromo-2- hydroxyphenyl)ethenesulfonic acid | 分子名称: | (E)-2-(5-BROMO-2-HYDROXYPHENYL)ETHENESULFONIC ACID, CARBONIC ANHYDRASE 2, ZINC ION | 著者 | Tars, K, Leitans, J, Kazaks, A. | 登録日 | 2012-10-03 | 公開日 | 2013-02-06 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Sulfocoumarins (1,2-Benzoxathiine-2,2-Dioxides): A Class of Potent and Isoform-Selective Inhibitors of Tumor-Associated Carbonic Anhydrases. J.Med.Chem., 56, 2013
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3D3I
| Crystal structural of Escherichia coli K12 YgjK, a glucosidase belonging to glycoside hydrolase family 63 | 分子名称: | CALCIUM ION, GLYCEROL, Uncharacterized protein ygjK | 著者 | Kurakata, Y, Uechi, A, Yoshida, H, Kamitori, S, Sakano, Y, Nishikawa, A, Tonozuka, T. | 登録日 | 2008-05-12 | 公開日 | 2008-06-03 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Structural insights into the substrate specificity and function of Escherichia coli K12 YgjK, a glucosidase belonging to the glycoside hydrolase family 63. J.Mol.Biol., 381, 2008
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8OPR
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2WAD
| PENICILLIN-BINDING PROTEIN 2B (PBP-2B) FROM STREPTOCOCCUS PNEUMONIAE (STRAIN 5204) | 分子名称: | PENICILLIN-BINDING PROTEIN 2B, ZINC ION | 著者 | Contreras-Martel, C, Dahout-Gonzalez, C, Dos-Santos-Martins, A, Kotnik, M, Dessen, A. | 登録日 | 2009-02-05 | 公開日 | 2009-02-24 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | Pbp Active Site Flexibility as the Key Mechanism for Beta-Lactam Resistance in Pneumococci J.Mol.Biol., 387, 2009
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1RVD
| H-RAS COMPLEXED WITH DIAMINOBENZOPHENONE-BETA,GAMMA-IMIDO-GTP | 分子名称: | 3-AMINOBENZOPHENONE-4-YL-AMINOHYDROXYPHOSPHINYLAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, TRANSFORMING PROTEIN P21/H-RAS-1 | 著者 | Ahmadian, M.R, Zor, T, Vogt, D, Kabsch, W, Selinger, Z, Wittinghofer, A, Scheffzek, K. | 登録日 | 1999-05-03 | 公開日 | 1999-05-28 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Guanosine triphosphatase stimulation of oncogenic Ras mutants. Proc.Natl.Acad.Sci.USA, 96, 1999
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7A74
| Structure of G132N BlaC from Mycobacterium tuberculosis | 分子名称: | 1,2-ETHANEDIOL, Beta-lactamase, GLYCEROL, ... | 著者 | Chikunova, A, Ahmad, M.U, Perrakis, A, Ubbink, M. | 登録日 | 2020-08-27 | 公開日 | 2021-05-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Two beta-Lactamase Variants with Reduced Clavulanic Acid Inhibition Display Different Millisecond Dynamics. Antimicrob.Agents Chemother., 65, 2021
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4GEQ
| Crystal structure of the Spc24-Spc25/Cnn1 binding interface | 分子名称: | GLYCEROL, Kinetochore protein SPC24, Kinetochore protein SPC25, ... | 著者 | Malvezzi, F, Litos, G, Schleiffer, A, Heuck, A, Clausen, T, Westermann, S. | 登録日 | 2012-08-02 | 公開日 | 2013-01-30 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors. Embo J., 32, 2013
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1FFT
| The structure of ubiquinol oxidase from Escherichia coli | 分子名称: | COPPER (II) ION, HEME O, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Abramson, J, Riistama, S, Larsson, G, Jasaitis, A, Svensson-Ek, M, Puustinen, A, Iwata, S, Wikstrom, M. | 登録日 | 2000-07-26 | 公開日 | 2000-10-18 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | The structure of the ubiquinol oxidase from Escherichia coli and its ubiquinone binding site. Nat.Struct.Biol., 7, 2000
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2OJH
| The structure of putative TolB from Agrobacterium tumefaciens | 分子名称: | ACETIC ACID, Uncharacterized protein Atu1656/AGR_C_3050 | 著者 | Cuff, M.E, Xu, X, Gu, J, Edwards, A, Savchenko, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2007-01-12 | 公開日 | 2007-02-27 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | The structure of putative TolB from Agrobacterium tumefaciens TO BE PUBLISHED
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6TZP
| W96F Oxalate Decarboxylase (B. subtilis) | 分子名称: | MANGANESE (II) ION, Oxalate decarboxylase | 著者 | Pastore, A.J, Burg, M.J, Twahir, U.T, Bruner, S.D, Angerhofer, A. | 登録日 | 2019-08-12 | 公開日 | 2021-02-17 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Oxalate decarboxylase uses electron hole hopping for catalysis. J.Biol.Chem., 297, 2021
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1FB1
| CRYSTAL STRUCTURE OF HUMAN GTP CYCLOHYDROLASE I | 分子名称: | GTP CYCLOHYDROLASE I, ISOPROPYL ALCOHOL, ZINC ION | 著者 | Auerbach, G, Herrmann, A, Bracher, A, Bader, G, Gutlich, M, Fischer, M, Neukamm, M, Nar, H, Garrido-Franco, M, Richardson, J, Huber, R, Bacher, A. | 登録日 | 2000-07-14 | 公開日 | 2000-12-08 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Zinc plays a key role in human and bacterial GTP cyclohydrolase I. Proc.Natl.Acad.Sci.USA, 97, 2000
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5KE0
| Discovery of 1-1H-Pyrazolo 4,3-c pyridine-6-yl urea Inhibitors of Extracellular Signal Regulated Kinase ERK for the Treatment of Cancers | 分子名称: | 1-[3-(2-methylpyridin-4-yl)-1~{H}-pyrazolo[4,3-c]pyridin-6-yl]-3-(phenylmethyl)urea, Mitogen-activated protein kinase 1, SULFATE ION | 著者 | Hruza, A, Lim, J. | 登録日 | 2016-06-09 | 公開日 | 2016-07-06 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Discovery of 1-(1H-Pyrazolo[4,3-c]pyridin-6-yl)urea Inhibitors of Extracellular Signal-Regulated Kinase (ERK) for the Treatment of Cancers. J.Med.Chem., 59, 2016
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8BG9
| Murine amyloid-beta filaments with the Arctic mutation (E22G) from APP(NL-G-F) mouse brains | ABeta | 分子名称: | Amyloid-beta protein 40 | 著者 | Yang, Y, Zhang, W.J, Murzin, A.G, Schweighauser, M, Huang, M, Lovestam, S.K.A, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Ghetti, B, Graff, C, Kumar, A, Nordber, A, Goedert, M, Scheres, S.H.W. | 登録日 | 2022-10-27 | 公開日 | 2023-01-18 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains. Acta Neuropathol, 145, 2023
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