5B5H
| Hydrophobic ice-binding site confer hyperactivity on antifreeze protein from a snow mold fungus | 分子名称: | Antifreeze protein, SODIUM ION, SULFATE ION | 著者 | Cheng, J, Hanada, Y, Miura, A, Tsuda, S, Kondo, H. | 登録日 | 2016-05-06 | 公開日 | 2016-09-28 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1 Å) | 主引用文献 | Hydrophobic ice-binding sites confer hyperactivity of an antifreeze protein from a snow mold fungus. Biochem.J., 473, 2016
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6LDI
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8U2Y
| Solution structure of the PHD6 finger of MLL4 bound to TET3 | 分子名称: | Histone-lysine N-methyltransferase 2D, Methylcytosine dioxygenase TET3, ZINC ION | 著者 | Mohid, S.A, Zandian, M, Zhang, Y, Kutateladze, T.G. | 登録日 | 2023-09-06 | 公開日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | MLL4 binds TET3. Structure, 32, 2024
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6LH8
| Structure of aerolysin-like protein (Bombina maxima) | 分子名称: | aerolysin-like protein | 著者 | Bian, X.L, Wang, Q.Q, Li, X, Teng, M.Q, Zhang, Y. | 登録日 | 2019-12-07 | 公開日 | 2020-06-10 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.729 Å) | 主引用文献 | A cellular endolysosome-modulating pore-forming protein from a toad is negatively regulated by its paralog under oxidizing conditions. J.Biol.Chem., 295, 2020
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6KZJ
| Crystal structure of Ankyrin B/NdeL1 complex | 分子名称: | Ankyrin-2, Nuclear distribution protein nudE-like 1 | 著者 | Ye, J, Li, J, Ye, F, Zhang, M, Zhang, Y, Wang, C. | 登録日 | 2019-09-24 | 公開日 | 2020-01-15 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Mechanistic insights into the interactions of dynein regulator Ndel1 with neuronal ankyrins and implications in polarity maintenance. Proc.Natl.Acad.Sci.USA, 117, 2020
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6LHZ
| Structure of aerolysin-like protein (Bombina maxima) | 分子名称: | aerolysin-like protein | 著者 | Bian, X.L, Wang, Q.Q, Li, X, Teng, M.Q, Zhang, Y. | 登録日 | 2019-12-10 | 公開日 | 2020-06-10 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | A cellular endolysosome-modulating pore-forming protein from a toad is negatively regulated by its paralog under oxidizing conditions. J.Biol.Chem., 295, 2020
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8IP0
| Cryo-EM structure of type I-B Cascade bound to a PAM-containing dsDNA target at 3.6 angstrom resolution | 分子名称: | CRISPR associated protein Cas11b, DNA (41-MER), DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), ... | 著者 | Xiao, Y, Lu, M, Yu, C, Zhang, Y. | 登録日 | 2023-03-13 | 公開日 | 2024-03-20 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure and genome editing of type I-B CRISPR-Cas. Nat Commun, 15, 2024
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5XM7
| Crystal structure of Plasmodium falciparum aminopeptidase N in complex with (S)-2-((2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido)-N-hydroxy-4-methylpentanamide | 分子名称: | (2S)-4-methyl-N-[(1R)-2-(oxidanylamino)-2-oxidanylidene-1-phenyl-ethyl]-2-[(phenylmethyl)carbamoylamino]pentanamide, GLYCEROL, M1 family aminopeptidase, ... | 著者 | Marapaka, A.K, Zhang, Y, Addlagatta, A. | 登録日 | 2017-05-12 | 公開日 | 2018-06-20 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Development of peptidomimetic hydroxamates as PfA-M1 and PfA-M17 dual inhibitors: Biological evaluation and structural characterization by cocrystallization Chin.Chem.Lett., 33, 2022
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5X57
| Structure of GAR domain of ACF7 | 分子名称: | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5, NICKEL (II) ION | 著者 | Yang, F, Wang, T, Zhang, Y, Wu, X.Y. | 登録日 | 2017-02-15 | 公開日 | 2017-07-05 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics. Nat Commun, 8, 2017
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5XXH
| Crystal Structure Analysis of the CBP | 分子名称: | (3S)-1-[2-(3-ethanoylindol-1-yl)ethanoyl]piperidine-3-carboxylic acid, 1,2-ETHANEDIOL, CREB-binding protein, ... | 著者 | Xiang, Q, Zhang, Y, Wang, C, Song, M. | 登録日 | 2017-07-04 | 公開日 | 2018-06-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer. Eur J Med Chem, 147, 2018
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2K29
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5Y1T
| Crystal structure of Plasmodium falciparum aminopeptidase N in complex with (S)-2-(3-(2,3-dimethylbenzyl)ureido)-N-hydroxy-4-methylpentanamide | 分子名称: | (2S)-2-[(2,3-dimethylphenyl)methylcarbamoylamino]-4-methyl-N-oxidanyl-pentanamide, GLYCEROL, M1 family aminopeptidase, ... | 著者 | Marapaka, A.K, Zhang, Y, Addlagatta, A. | 登録日 | 2017-07-21 | 公開日 | 2018-08-01 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Development of peptidomimetic hydroxamates as PfA-M1 and PfA-M17 dual inhibitors: Biological evaluation and structural characterization by cocrystallization Chin.Chem.Lett., 33, 2022
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8V2F
| Crystal structure of IRAK4 kinase domain with compound 9 | 分子名称: | CHLORIDE ION, GLYCEROL, Interleukin-1 receptor-associated kinase 4, ... | 著者 | Weiss, M.M, Zheng, X, Browne, C.M, Campbell, V, Chen, D, Enerson, B, Fei, X, Huang, X, Klaus, C.R, Li, H, Mayo, M, McDonald, A.A, Paul, A, Sharma, K, Shi, Y, Slavin, A, Walter, D.M, Yuan, K, Zhang, Y, Zhu, X, Kelleher, J, Ji, N, Walker, D, Mainolfi, N. | 登録日 | 2023-11-22 | 公開日 | 2024-07-03 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B-Cell Lymphoma. J.Med.Chem., 67, 2024
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8V1O
| Crystal structure of IRAK4 kinase domain with compound 4 | 分子名称: | CHLORIDE ION, GLYCEROL, Interleukin-1 receptor-associated kinase 4, ... | 著者 | Weiss, M.M, Zheng, X, Browne, C.M, Campbell, V, Chen, D, Enerson, B, Fei, X, Huang, X, Klaus, C.R, Li, H, Mayo, M, McDonald, A.A, Paul, A, Sharma, K, Shi, Y, Slavin, A, Walter, D.M, Yuan, K, Zhang, Y, Zhu, X, Kelleher, J, Ji, N, Walker, D, Mainolfi, N. | 登録日 | 2023-11-21 | 公開日 | 2024-07-03 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (2.92 Å) | 主引用文献 | Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B-Cell Lymphoma. J.Med.Chem., 67, 2024
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8V2L
| Crystal structure of IRAK4 kinase domain with compound 8 | 分子名称: | 1,2-ETHANEDIOL, Interleukin-1 receptor-associated kinase 4, N-{2-[4-(hydroxymethyl)phenyl]-6-(2-hydroxypropan-2-yl)-2H-indazol-5-yl}-6-(trifluoromethyl)pyridine-2-carboxamide | 著者 | Weiss, M.M, Zheng, X, Browne, C.M, Campbell, V, Chen, D, Enerson, B, Fei, X, Huang, X, Klaus, C.R, Li, H, Mayo, M, McDonald, A.A, Paul, A, Sharma, K, Shi, Y, Slavin, A, Walter, D.M, Yuan, K, Zhang, Y, Zhu, X, Kelleher, J, Ji, N, Walker, D, Mainolfi, N. | 登録日 | 2023-11-22 | 公開日 | 2024-07-03 | 最終更新日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Discovery of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates Targeting MYD88 Mutant Diffuse Large B-Cell Lymphoma. J.Med.Chem., 67, 2024
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5Y1K
| Crystal structure of Plasmodium falciparum aminopeptidase N in complex with (S)-2-(3-(2-chlorobenzyl)ureido)-N-hydroxy-4-methylpentanamide | 分子名称: | (2S)-2-[(2-chlorophenyl)methylcarbamoylamino]-4-methyl-N-oxidanyl-pentanamide, GLYCEROL, M1 family aminopeptidase, ... | 著者 | Marapaka, A.K, Zhang, Y, Addlagatta, A. | 登録日 | 2017-07-20 | 公開日 | 2018-08-01 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Development of peptidomimetic hydroxamates as PfA-M1 and PfA-M17 dual inhibitors: Biological evaluation and structural characterization by cocrystallization Chin.Chem.Lett., 33, 2022
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5YPS
| The structural basis of histone chaperoneVps75 | 分子名称: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Chen, Y, Zhang, Y, Dou, Y, Wang, M, Xu, S, Jiang, H, Limper, A, Su, D. | 登録日 | 2017-11-03 | 公開日 | 2018-11-07 | 最終更新日 | 2020-06-10 | 実験手法 | X-RAY DIFFRACTION (2.097 Å) | 主引用文献 | Structural basis for the acetylation of histone H3K9 and H3K27 mediated by the histone chaperone Vps75 inPneumocystis carinii. Signal Transduct Target Ther, 4, 2019
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5Y1Q
| Crystal structure of Plasmodium falciparum aminopeptidase N in complex with (S)-2-(3-(3-chlorobenzyl)ureido)-N-hydroxy-4-methylpentanamide | 分子名称: | (2S)-2-[(3-chlorophenyl)methylcarbamoylamino]-4-methyl-N-oxidanyl-pentanamide, M1 family aminopeptidase, MAGNESIUM ION, ... | 著者 | Marapaka, A.K, Zhang, Y, Addlagatta, A. | 登録日 | 2017-07-21 | 公開日 | 2018-08-01 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Development of peptidomimetic hydroxamates as PfA-M1 and PfA-M17 dual inhibitors: Biological evaluation and structural characterization by cocrystallization Chin.Chem.Lett., 33, 2022
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2V0C
| LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A SULPHAMOYL ANALOGUE OF LEUCYL-ADENYLATE In the synthetic site and an adduct of AMP with 5-Fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690) in the editing site | 分子名称: | AMINOACYL-TRNA SYNTHETASE, LEUCINE, SULFATE ION, ... | 著者 | Rock, F, Mao, W, Yaremchuk, A, Tukalo, M, Crepin, T, Zhou, H, Zhang, Y, Hernandez, V, Akama, T, Baker, S, Plattner, J, Shapiro, L, Martinis, S.A, Benkovic, S.J, Cusack, S, Alley, M.R.K. | 登録日 | 2007-05-14 | 公開日 | 2007-07-03 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site. Science, 316, 2007
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5IMR
| Structure of ribosome bound to cofactor at 5.7 angstrom resolution | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Kumar, V, Ero, R, Jian, G.K, Ahmed, T, Zhan, Y, Bhushan, S, Gao, Y.G. | 登録日 | 2016-03-06 | 公開日 | 2016-05-18 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (5.7 Å) | 主引用文献 | Structure of the GTP Form of Elongation Factor 4 (EF4) Bound to the Ribosome J.Biol.Chem., 291, 2016
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6BXL
| Crystal structure of Pyrococcus horikoshii Dph2 with 4Fe-4S cluster and SAM | 分子名称: | 2-(3-amino-3-carboxypropyl)histidine synthase, IRON/SULFUR CLUSTER, S-ADENOSYLMETHIONINE | 著者 | Torelli, A.T, Fenwick, M.K, Zhang, Y, Dong, M, Kathiresan, V, Carantoa, J.D, Dzikovski, B, Lancaster, K.M, Freed, J.H, Hoffman, B.M, Lin, H, Ealick, S.E. | 登録日 | 2017-12-18 | 公開日 | 2018-04-11 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.301 Å) | 主引用文献 | Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis. Science, 359, 2018
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6BXM
| Crystal structure of Candidatus Methanoperedens nitroreducens Dph2 with 4Fe-4S cluster and SAM/cleaved SAM | 分子名称: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, ALPHA-AMINOBUTYRIC ACID, Diphthamide biosynthesis enzyme Dph2, ... | 著者 | Fenwick, M.K, Torelli, A.T, Zhang, Y, Dong, M, Kathiresan, V, Carantoa, J.D, Dzikovski, B, Lancaster, K.M, Freed, J.H, Hoffman, B.M, Lin, H, Ealick, S.E. | 登録日 | 2017-12-18 | 公開日 | 2018-04-11 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.252 Å) | 主引用文献 | Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis. Science, 359, 2018
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6BXO
| Crystal structure of Candidatus Methanoperedens nitroreducens Dph2 with 4Fe-4S cluster and SAH | 分子名称: | Diphthamide biosynthesis enzyme Dph2, IRON/SULFUR CLUSTER, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Fenwick, M.K, Torelli, A.T, Zhang, Y, Dong, M, Kathiresan, V, Carantoa, J.D, Dzikovski, B, Lancaster, K.M, Freed, J.H, Hoffman, B.M, Lin, H, Ealick, S.E. | 登録日 | 2017-12-18 | 公開日 | 2018-04-11 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.655 Å) | 主引用文献 | Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis. Science, 359, 2018
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8WM0
| Crystal structure of TNIK-thiopeptide wTP3 complex | 分子名称: | ADENOSINE, THIOPEPTIDE wTP3, TRAF2 and NCK-interacting protein kinase | 著者 | Hamada, K, Kobayashi, S, Vinogradov, A.A, Zhang, Y, Goto, Y, Suga, H, Ogata, K, Sengoku, T. | 登録日 | 2023-10-01 | 公開日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | A Compact Reprogrammed Genetic Code for De Novo Discovery of Proteolytically Stable Thiopeptides. J.Am.Chem.Soc., 2024
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4MZ7
| Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... | 著者 | Zhu, C, Gao, W, Zhao, K, Qin, X, Zhang, Y, Peng, X, Zhang, L, Dong, Y, Zhang, W, Li, P, Wei, W, Gong, Y, Yu, X.F. | 登録日 | 2013-09-29 | 公開日 | 2013-11-20 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural insight into dGTP-dependent activation of tetrameric SAMHD1 deoxynucleoside triphosphate triphosphohydrolase Nat Commun, 4, 2013
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