5XM7

Crystal structure of Plasmodium falciparum aminopeptidase N in complex with (S)-2-((2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido)-N-hydroxy-4-methylpentanamide

Summary for 5XM7

Entry DOI	10.2210/pdb5xm7/pdb
Descriptor	M1 family aminopeptidase, ZINC ION, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	aminopeptidase, m1-class, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Plasmodium falciparum (isolate FcB1 / Columbia)
Total number of polymer chains	1
Total formula weight	107855.32
Authors	Marapaka, A.K.,Zhang, Y.,Addlagatta, A. (deposition date: 2017-05-12, release date: 2018-06-20, Last modification date: 2023-11-22)
Primary citation	Marapaka, A.K.,Sankoju, P.,Zhang, G.,Ding, Y.,Ma, C.,Pillalamarri, V.,Sudhakar, P.,Reddi, B.,Sijwali, P.S.,Zhang, Y.,Addlagatta, A. Development of peptidomimetic hydroxamates as PfA-M1 and PfA-M17 dual inhibitors: Biological evaluation and structural characterization by cocrystallization Chin.Chem.Lett., 33:2550-2554, 2022 Cited by DOI: 10.1016/j.cclet.2021.09.102 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.96 Å)

Structure validation