5XM7
Crystal structure of Plasmodium falciparum aminopeptidase N in complex with (S)-2-((2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido)-N-hydroxy-4-methylpentanamide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | M1 family aminopeptidase | polymer | 914 | 106291.5 | 1 | UniProt (O96935) Pfam (PF17900) Pfam (PF01433) Pfam (PF11940) Pfam (PF17432) In PDB | Plasmodium falciparum (isolate FcB1 / Columbia) | Pfa-M1 |
2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
3 | A | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
4 | A | GLYCEROL | non-polymer | 92.1 | 11 | Chemie (GOL) | |||
5 | A | (2S)-4-methyl-N-[(1R)-2-(oxidanylamino)-2-oxidanylidene-1-phenyl-ethyl]-2-[(phenylmethyl)carbamoylamino]pentanamide | non-polymer | 412.5 | 1 | Chemie (89X) | |||
6 | water | water | 18.0 | 380 | Chemie (HOH) |
Sequence modifications
A: 195 - 1085 (UniProt: O96935)
PDB | External Database | Details |
---|---|---|
Met 172 | - | expression tag |
Gly 173 | - | expression tag |
Ser 174 | - | expression tag |
Ser 175 | - | expression tag |
His 176 | - | expression tag |
His 177 | - | expression tag |
His 178 | - | expression tag |
His 179 | - | expression tag |
His 180 | - | expression tag |
His 181 | - | expression tag |
Ser 182 | - | expression tag |
Ser 183 | - | expression tag |
Gly 184 | - | expression tag |
Leu 185 | - | expression tag |
Val 186 | - | expression tag |
Pro 187 | - | expression tag |
Arg 188 | - | expression tag |
Gly 189 | - | expression tag |
Ser 190 | - | expression tag |
His 191 | - | expression tag |
Met 192 | - | expression tag |
Ala 193 | - | expression tag |
Ser 194 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 106291.5 | |
Non-Polymers* | Number of molecules | 16 |
Total formula weight | 1563.8 | |
All* | Total formula weight | 107855.3 |