2V0C
LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A SULPHAMOYL ANALOGUE OF LEUCYL-ADENYLATE In the synthetic site and an adduct of AMP with 5-Fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690) in the editing site
Summary for 2V0C
Entry DOI | 10.2210/pdb2v0c/pdb |
Related | 1H3N 1OBC 1OBH 2BTE 2BYT |
Descriptor | AMINOACYL-TRNA SYNTHETASE, LEUCINE, [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDRO-2-FURANYL]METHYL SULFAMATE, ... (7 entities in total) |
Functional Keywords | ligase, nucleotide-binding, protein biosynthesis, clss i aminoacyl- trna synthetase, atp + l-leucine + trna (leu) gives amp + ppi + l-leucyl-trna(leu), aminoacyl-trna synthetase, zinc, atp-binding, metal-binding |
Biological source | THERMUS THERMOPHILUS |
Total number of polymer chains | 1 |
Total formula weight | 102566.67 |
Authors | Rock, F.,Mao, W.,Yaremchuk, A.,Tukalo, M.,Crepin, T.,Zhou, H.,Zhang, Y.,Hernandez, V.,Akama, T.,Baker, S.,Plattner, J.,Shapiro, L.,Martinis, S.A.,Benkovic, S.J.,Cusack, S.,Alley, M.R.K. (deposition date: 2007-05-14, release date: 2007-07-03, Last modification date: 2023-12-13) |
Primary citation | Rock, F.,Mao, W.,Yaremchuk, A.,Tukalo, M.,Crepin, T.,Zhou, H.,Zhang, Y.,Hernandez, V.,Akama, T.,Baker, S.,Plattner, J.,Shapiro, L.,Martinis, S.A.,Benkovic, S.J.,Cusack, S.,Alley, M.R.K. An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site. Science, 316:1759-, 2007 Cited by PubMed: 17588934DOI: 10.1126/SCIENCE.1142189 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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